A5080355023- Respiratory viral infections research
- Urinary Tract Infections Management
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Pediatric Urology and Nephrology Studies
- Pneumonia and Respiratory Infections
- Embedded Systems Design Techniques
- Low-power high-performance VLSI design
- VLSI and FPGA Design Techniques
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Cytomegalovirus and herpesvirus research
- Ginseng Biological Effects and Applications
- Viral Infections and Immunology Research
- Nosocomial Infections in ICU
- Viral gastroenteritis research and epidemiology
- Orthopedic Infections and Treatments
- Urinary Bladder and Prostate Research
- Antibiotic Resistance in Bacteria
- Long-Term Effects of COVID-19
- Antibiotic Use and Resistance
- Water Quality Monitoring Technologies
- Herpesvirus Infections and Treatments
- Otolaryngology and Infectious Diseases
- Optimization and Mathematical Programming
China Medical University
2013-2025
China Medical University Hospital
2013-2025
National Yang Ming Chiao Tung University
2022
National Taipei University of Technology
2022
Ministry of Health and Welfare
2021
Children's Hospital
2016
National Chung Hsing University
2002-2003
National Taipei University
2002
The global evolution of pathogens causing early-onset sepsis (EOS), a critical condition in preterm infants, necessitates re-evaluation risk factors to develop updated prevention and treatment strategies. This nationwide case–control study Taiwan analyzed data from the National Health Insurance Research Database, Birth Reporting Maternal Child Database 2010 2019. included 176,681 mother–child pairs with births. We identified 2942 clinical EOS cases 5535 diagnosed cases, excluding unlikely...
Abstract Background Post-acute sequelae of SARS-CoV-2 infection (PASC) is a condition that impacts certain children following recovery from COVID-19. Programmed death-1 (PD-1) and its ligands, PD-L1 PD-L2, may play critical role in the immune response PASC. However, specific functions these components PASC among pediatric patients remain unclear. Methods The study participants were recruited DISCOVER (Diagnosis Support for COVID Children to Enhance Recovery) study, conducted at China Medical...
Abstract Background Respiratory Syncytial Virus (RSV) and Human Metapneumovirus (hMPV) are prevalent pathogens responsible for respiratory tract infections in infants young children. This study aims to conduct a comprehensive analysis of the clinical presentations outcomes among hospitalized children with RSV hMPV infections. Methods retrospective observational was conducted at China Medical University Children's Hospital (CMUCH) from January 2020 December 2021. The enrolled patients under 5...
The COVID-19 pandemic and Taiwan’s strict prevention policies from May 2020 to April 2023 significantly altered the epidemiology of viral infections. This study analyzed pediatric influenza cases at Wei Gong Memorial Hospital January 2015 March 2024. Clinical features were compared among children hospitalized during Omicron BA.2.3.7 (April–July 2022), BA.5 (August–December JN.1 (2024) waves those with in 2024 2015–2016. Between 2024, there 2729 A (36.6%), 974 B (13.1%), 3752 (50.3%) cases,...
Urinary tract infections (UTIs) are one of the most common pediatric infections. Our objective in this study is to investigate association between urine pH and uropathogens patients. The source population comprised 26 066 paired urinalysis (UA) culture (UC) samples obtained from We classified UA–UC into UTI positive (N = 6348) negative 19 718) according colony forming units corresponding sampling source. included patients with infection caused by a single species pathogen 5201) frequency...
Herpes zoster is rare in healthy children, but immunocompromised persons have an increased risk of herpes and severe diseases. Considering the very limited information on children with cancer, we performed a nationwide population-based cohort study to estimate incidence cancer explore association between 2 Data were obtained from National Health Research Institutes Database Taiwan. A total 4432 newly diagnosed 2000 2007 identified as cohort, 17,653 without frequency-matched by sex age at...
Bacterial coinfections have been widely recognized in adults with coronavirus disease 2019 (COVID-19). However, bacterial hospitalized children severe acute respiratory syndrome 2 (SARS-CoV-2) not sufficiently researched. This study aimed to determine the clinical presentations and risk factors for of pediatric inpatients during SARS-CoV-2 Omicron BA.2 variant pandemic. retrospective, observational included patients younger than 18 years age who were COVID-19 confirmed by polymerase chain...
Background: Post-acute sequelae of SARS-CoV-2 infection (PASC) affects patients after recovering from acute coronavirus disease 2019 (COVID-19). This study investigates the impact vaccination on PASC symptoms in children Taiwan during Omicron pandemic. Methods: We enrolled under 18 years with persisting for more than 4 weeks. Data collected included demographics, clinical information, status, and symptom persistence. used logistic regression models to compare post-COVID-19 phases assess...
We report 2 cases of neonatal Legionella infection associated with aspiration contaminated water used in hospitals to make infant formula. The molecular profiles strains isolated from samples the infants and dispensers were indistinguishable. Our highlights need consider nosocomial legionellosis among neonates who have respiratory symptoms.
The causative pathogen of pediatric osteomyelitis is often unidentified despite culturing attempts. This study evaluated and compared the clinical characteristics, therapeutic approach, outcomes caused by unknown pathogens identified microorganisms.This 17-year retrospective was conducted at a tertiary hospital in central Taiwan. Medical records children aged less than 18 years with diagnosis between 2003 2019 were reviewed.In total, 70 patients (median age = 6.4 years; male 65.7%) fulfilled...
Dear Editor, Influenza viruses are transmitted through droplets and particle aerosols from the coughs sneezes of infected people contact with surfaces that have been contaminated. In addition to receiving an influenza vaccine, wearing a mask observing strict hand hygiene essential preventing infection.1 The annual season in Taiwan is typically November March. On January 21, 2020, fourth week recorded its first case COVID-19. Because 2003 SARS epidemic was traumatic for Taiwan, most began...
Aplastic Anemia (AA) is a rare but fatal hematologic disease that may occur at any age and especially higher in Asia. We investigated whether Chinese herbal medicine (CHM) beneficial to AA patients as complementary therapy using nationwide population-based database Taiwan between 2000-2016. Patient survival was estimated by Kaplan‒Meier analyses Cox proportional-hazard model. CHM-users presented lower risks of overall anemia-related mortalities when compared non-users. The risk mortality for...
Respiratory tract infections (RTIs) represent a major cause of clinical visits worldwide. Viral epidemiology RTIs in adults has been less studied compared to children. FilmArray respiratory panel (FA-RP), multiplex, real time polymerase chain reaction method can simultaneously detect the nucleic acids multiple pathogens. The purpose this study is analyze and presentations an RTI cohort. This retrospective cohort was conducted at China Medical University Hospital (CMUH) Children's (CMUCH),...
Power management has become a great concern in VLSI design recent years. In this paper, we consider the logic level technique for low power applications. We present retiming-based optimization method, which part of circuit is selected and moved so that it produces signals one clock cycle before they are actually applied. If these values can solely determine output level, then other be turned-off to save power. explore acceptable retimed structures, function not changed. An algorithm proposed...
Abstract Gram-positive (GP) pathogens are less accounted for in pediatric urinary tract infection (UTI), and their clinical impact is underrecognized. This study aimed to identify predictors of GP uropathogens UTI. In this 14-year retrospective cohort patients with UTI, we classified first-time UTIs cases into those caused by or Gram-negative (GN) bacteria. We constructed a multivariable logistic regression model predict evaluated performance through calibration discrimination plots....
Hereditary Hemolytic Anemias (HHAs) are a rare but heterogeneous group of erythrocytic diseases, characterized by intrinsic cellular defects due to inherited genetic mutations. We investigated the efficacy Chinese herbal medicine (CHM) in reducing overall, diabetes-related, and cardiovascular diseases (CVDs)-related mortalities among patients with HHAs using nationwide population database. In total, we identified 33,278 included 9,222 non-CHM CHM matched pairs after matching. The Cox...