A5038966587- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive biology and impacts on aquatic species
- Aquatic Ecosystems and Phytoplankton Dynamics
- Marine and coastal ecosystems
- Iron Metabolism and Disorders
- Pancreatic function and diabetes
- Sperm and Testicular Function
- Advanced Glycation End Products research
- Erythropoietin and Anemia Treatment
- Renal and related cancers
- Hormonal and reproductive studies
- Hemoglobinopathies and Related Disorders
- Marine Toxins and Detection Methods
- Advanced Computational Techniques and Applications
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Aquatic Ecosystems and Biodiversity
- Ferroptosis and cancer prognosis
- Regulation of Appetite and Obesity
- Reproductive System and Pregnancy
- Energy Efficient Wireless Sensor Networks
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Chemotherapy-induced organ toxicity mitigation
- Mitochondrial Function and Pathology
Army Medical University
2024
Daping Hospital
2024
China Three Gorges Corporation (China)
2022-2023
Institute of Hydrobiology
2017-2023
Chinese Academy of Sciences
2011-2023
China Three Gorges University
2023
University of Chinese Academy of Sciences
2017-2022
Nanjing Medical University
2010-2022
Fourth Affiliated Hospital of Guangxi Medical University
2021
Dalian Medical University
2020
Cytochrome P450 (Cyp)17A1 has both 17α-hydroxylase and 17,20-lyase activities, which are involved in the steroidogenic pathway that produces androgens estrogens. Previously, a phenotype of all-male cyp17a1-deficient zebrafish generated by transcription activatorlike effector nuclease been reported. In current study, mechanisms relating to Cyp17a1 development sexual traits, especially gonadal differentiation testicular development, were characterized. We found fish at 3 months...
Due to sexual dimorphism in the growth of certain cultured fish species, production monosex fishes is desirable for aquaculture industry. Nowadays, most widely practiced technique available mass populations sex steroid-induced reversal. Here, a novel strategy successful all-female (AF) common carp (Cyprinus carpio L.), take advantage documented this has been developed using genetic engineering via single gene-targeting manipulation without any exogenous hormone treatments. Male and female...
Disruption of androgen signaling is known to cause testicular malformation and defective spermatogenesis in zebrafish. However, knockout
Advanced glycation end products (AGEs) have been implicated in diverse pathological settings of many diabetic complications, and the possible mechanisms widely reported. However, relationship between AGEs pancreatic β-cell dysfunction is still poorly understood. Recent studies shown that can impair function by inducing apoptosis or decreasing insulin secretion. Our previous research revealed could significantly down-regulate transcription reduce glucose-stimulated secretion (GSIS). Here, we...
Anemia is a common hematological abnormality in patients with cancer. Iron deficiency anemia (IDA) and of chronic disease (ACD) are the most prevalent, both characterized by hypochromic microcytic low serum iron (SI). Their differential diagnosis difficult clinical practice, hampering their treatment. Our objective was to evaluate use hepcidin discriminate tumor-related IDA ACD investigate mechanism action these anemias.Blood samples were collected at Jiangsu Cancer Hospital. Patients...
Brain sex differentiation is a complex process, wherein genes and steroid hormones act to induce specific gender brain differentiation. Testosterone (T) derived from the gonads has been linked neural circuit modeling in sex-specific manner. Previously, we have shown that cyp17a1 knockout (KO) zebrafish low plasma androgen levels, display compromised male-typical mating behaviors. In this study, demonstrated treatment of KO males with T or 11-ketotestosterone (11-KT) sufficient rescue...
It has been well established that glucotoxicity induces pancreatic β-cells dysfunction; however, the precise mechanism remains unclear. Our previous studies demonstrated high glucose concentrations are associated with decreased hepcidin expression, which inhibits insulin synthesis. In this study, we focused on role of low level-induced increased iron deposition in and relationship between abnormal metabolism β-cell dysfunction. Decreased expression absorption by upregulating transferrin...
Sepsis-induced cardiac dysfunction is one of the most serious complications sepsis. The mitochondrial translocator protein (TSPO), a outer membrane protein, widely used as diagnostic marker inflammation-related diseases and can also lead to release inflammatory components. However, whether TSPO has therapeutic effect on sepsis-induced unclear.
ADAMTS-13 plays an important role in acute kidney injury (AKI), but the mechanism of cisplatin (CP) induced AKI remains unclear. Ferroptosis is increased CP-induced AKI, and ADAMTS13 levels are associated with ferritin expression. In this article, we will explore relationship between three. After CP induction, mice were given 0.1 0.3 nmol/kg ADAMTS-13, then serum creatinine (Scr) blood urea nitrogen (BUN) detected by kits. The pathological changes renal tissue observed staining HE PAS...
Introduction 1α,25-dihydroxyvitamin D3 (1α,25[OH] 2 VD 3 ) is a hormone known for its key roles in calcium absorption and nutrient metabolism. In teleost fishes, 1α,25(OH) insufficiency causes impaired glucose metabolism lipid oxidation. However, the cascade mechanisms of vitamin d receptor (VDR) signaling are unclear. Results this study, two genes ( vdra vdrb encoding paralogs VDRs were genetically knocked out zebrafish. Growth retardation accumulated visceral adipose tissue have been...
Gluco-toxicity is a term used to convey the detrimental effect of hyperglycemia on β-cell function through impaired insulin synthesis. Although it known that expression and activity several key transcription regulators inhibited, other molecular mechanisms mediate gluco-toxicity are poorly defined. Our objective was explore role hepcidin in gluco-toxicity.We first confirmed high glucose levels inhibited mouse insulinoma cell line, MIN6. The downregulation decreased Pdx-1 expression, which...
Insulin-like growth factor 1 (IGF1) is an essential effector of the hormone (GH)/IGF1 axis for somatic regulation in mammals. However, its functions have not been thoroughly investigated zebrafish vivo . In this study, igf1 -deficient model was developed using CRISPR/Cas9 technique. study all results were performed on both male and female animals. The reduced. deficiency leads to significant complementary up-regulation transcriptional expression levels insulin, igf2 igf3 This suggested that...
Receptor of advanced glycation end products (RAGE) mediates diverse signal transduction following ligand stimulation and plays an important role in diabetes complications aging associated disease. We have previously verified that (AGE) bind to RAGE cause pancreatic β-cell apoptosis through the mitochondrial pathway. However, direct interacting protein(s) β cells has never been appreciated. In present study, we utilized GST pull-down assay combined with mass spectrometry identify proteins...
Unlike the Cytochrome P450, family 17, subfamily A, member 1 (Cyp17a1), which possesses both 17α-hydroxylase and 17,20-lyase activities involved in steroidogenic pathway that produces androgens estrogens, polypeptide 2 (Cyp17a2) only activity is known essential for synthesis of cortisol. Besides with expressed testes ovaries, where cyp17a1 mainly expressed, cyp17a2 also interrenal gland fish. Until now, roles fish, especially sexual traits development hypothalamic-pituitary-interrenal (HPI)...