A5067471564- Drug-Induced Hepatotoxicity and Protection
- Stress Responses and Cortisol
- Thyroid Disorders and Treatments
- Paraquat toxicity studies and treatments
- Liver Disease Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Mesenchymal stem cell research
- Nigella sativa pharmacological applications
- Electrolyte and hormonal disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Ginseng Biological Effects and Applications
- S100 Proteins and Annexins
- Electrospun Nanofibers in Biomedical Applications
- Medicinal Plants and Bioactive Compounds
- Natural Antidiabetic Agents Studies
- Ovarian function and disorders
- MicroRNA in disease regulation
- Tannin, Tannase and Anticancer Activities
- Pesticide and Herbicide Environmental Studies
- Thyroid Cancer Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Pomegranate: compositions and health benefits
- Sperm and Testicular Function
- Medicinal Plant Extracts Effects
- Essential Oils and Antimicrobial Activity
Lorestan University of Medical Sciences
2007-2024
Shiraz University of Medical Sciences
2013-2015
Ahvaz Jundishapur University of Medical Sciences
2007
As a potent herbicide capable of contaminating water and soil environments, paraquat, which is still widely used worldwide, toxic to mammals, algae, aquatic animals, etc. Paraquat was loaded on novel nanoparticles composed pectin, chitosan, sodium tripolyphosphate (PEC/CS/TPP). The size, polydispersity index, ζ potential were characterized. Further assessments carried out by SEM, AFM, FT-IR, DSC. encapsulation highly efficient, there delayed release pattern paraquat. encapsulated less...
There is increasing evidence indicating an aberrant expression of miRNAs in colorectal cancer (CRC) development. Growing has suggested that polyunsaturated fatty acids (PUFAs) could modulate the remodeling epigenome. No study yet been published to examine direct effect PUFA on promoter methylation miRNAs. This aimed potential clinical application DNA miR-126 and its angiogenic target molecule (VEGF) CRC cells. We investigated 100 μM EPA, DHA, LA for 24 h status a panel five cell lines...
Tannic acid (TA) is a potent antitumor agent, but its low bioavailability and absorption limit use. In this study, it was loaded into chitosan-based nanoparticles (Chi-NPs) to overcome these limitations improve antimicrobial anticancer activities. TA-loaded Chi-NPs (Chi-TA-NPs) were synthesized using the ionic gelation method physicochemically characterized by FE-SEM, FTIR, XRD, PDI, DLS, zeta potential analysis. Additionally, activity of Chi-TA-NPs against two G+ bacterial strains, G-...
Oxidative stress, has been shown to play an important role in the pathophysiology of cardiac remodelling and heart failure. The aim study is effect arginine vasopressin (AVP) on apoptosis cardiomyocyte via its receptors.The cell viability AVP H9C2 cardiomyocytes was assayed using MTT method. transcription translation level genes (Bax, Bcl-2, caspase-3) were discovered with qRT-PCR western blotting.The results showed that could reduce line through downregulation caspase-3, BAX upregulation...
Trauma and ventilator-induced lung injury is often associated with endothelial-epithelial barriers breakdown, which may lead to multiple system organ failure (MSOF) death in critically ill patients. Although molecular mechanism involved MSOF not known, junctional opening believed happen. In vitro, thyroid hormones inhibit myosin light chain (MLC) phosphorylation may, thus, cellular contraction opening. also tissue hypo-thyroid state. Therefore, we examined the effects of function on...
The purpose of this study was to evaluate the effects cerebral hypoperfusion on cognitive ability, TNFα, IL1β and PGE2 levels in both hippocampi a modified two-vessel occlusion model. Both common carotid arteries adult male Wistar rats were permanently occluded with an interval 1 week between occlusions. Learning memory significantly decreased after month. This reduction not significant 2 months, which may be attributed blood flow compensation. TNFα level increased 3 h day. After there no...
Abstract Introduction Liver injury is an important problem in healthcare. Thioacetamide (TAA)-induced liver established model experimental research for assessing the impact of various toxins and pharmaceuticals on liver. TAA induces its harmful effects by production oxidative biomolecules. Oxidative stress subsequently alters function, resulting alterations enzymatic activity aspartate aminotransferase (AST), alanine (ALT), alkaline phosphatase (ALP). Syzygium aromaticum has significant...
Introduction: Hereditary nephritis is an umbrella term for a group of congenital childhood diseases including but not limited to Alport syndrome, thin basement membrane disease, and Fabry disease. Objectives: The purpose this study was clinicopathologic investigation disease with focus on the role electron microscopy toluidine blue staining in diagnosis. Patients Methods: In cross-sectional study, we investigated kidney biopsies final diagnosis either or from 2001 2016. Electron light were...
Objective: Improvement of cell survival is essential for achieving better clinical outcomes in stem therapy. We investigated the effects hyperoxic pre-treatment (HP) on viability human adipose stromal cells (ASCs).Materials and Methods: MTT Western blot tests were used to assess expression apoptosis-related proteins, respectively. For in-vivo trial, rats subjected renal ischaemia-reperfusion (IR).Results: The results showed that HP could significantly increase ASCs decrease apoptotic markers...
There are many animal models for polycystic ovary (PCO); using exogenous testosterone enanthate is one of the methods induction these models. However, insulin resistance should also be studied in modeling technics. Therefore, present study aims to investigate expression receptor substrate (Irs)-2 mRNA liver tissue rat PCO model. Nineteen Wistar rats were divided into three groups; (1) group (N =7) received daily 1.0 mg/100g solved olive oil along with free access dextrose water 5%, (2)...