A5087151920- Saffron Plant Research Studies
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Phytochemical and Pharmacological Studies
- Flavonoids in Medical Research
- Silymarin and Mushroom Poisoning
- Diet and metabolism studies
- Medicinal Plants and Bioactive Compounds
- Cardiac Ischemia and Reperfusion
- Immunotherapy and Immune Responses
- Electrolyte and hormonal disorders
- Reproductive Biology and Fertility
- Regulation of Appetite and Obesity
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Synthesis and bioactivity of alkaloids
- Anesthesia and Neurotoxicity Research
- Medicinal Plant Extracts Effects
- Natural Antidiabetic Agents Studies
- Berberine and alkaloids research
- Hormonal and reproductive studies
- Drug Transport and Resistance Mechanisms
- SARS-CoV-2 and COVID-19 Research
Lorestan University of Medical Sciences
2017-2024
Tabriz University of Medical Sciences
2016-2019
Crocin is reported to have a wide range of biological activities such as cardiovascular protection. Recent epidemiologic studies shown that exercise reduces morbidity and mortality in the general population.The aim this study was evaluate effect crocin voluntary on miR-126 miR-210 expression levels angiogenesis heart tissue.Animals were divided into 4 groups: control, exercise, crocin, exercise-crocin. Animals received oral administration (50 mg/kg) or performed alone together for 8 weeks....
Background Oxidative stress plays a critical role in the pathogenesis and progression of type 2 diabetes diabetic-associated cardiovascular complications. This study investigated impact crocin combined with voluntary exercise on heart oxidative indicator high-fat diet-induced diabetic rats. Materials methods Rats were divided into four groups: diabetes, diabetic-crocin, diabetic-voluntary exercise, diabetic-crocin-voluntary exercise. Type was induced by diet (4 weeks) injection...
Triple-negative breast cancer has the poorest prognosis and survival rates compared to other subtypes due its invasive behaviours. This type of does not respond biological therapies exhibits resistance available treatment options. Therefore, it is imperative discover new therapeutics address this challenge.
Purpose: Pancreatic adenocarcinoma has a high prevalence all over the world. Most of therapeutic approaches failed as result tumor invasion and rapid metastasis. Several natural plants have been shown to promising effects. Thus, aim this study was investigate cytotoxic activity Eryngium billardieri against PANC-1 cancer cell lines. Methods: Dimethylthiazole diphenyltetrazolium bromide assay (MTT assay) flow cytometry were used assess cytotoxicity E. extracts Quantitative Polymerase Chain...
New Findings What is the central question of this study? Can low‐dose inorganic nitrate supplementation prevent testicular structural and functional alterations in streptozotocin‐induced type 1 diabetic male rats? main finding it's important? Treatment with a low dose for 2 months had protective effects on reproductive system rats including improved body weight loss, sperm testis parameters, spermatogenesis index histology as well increased serum testosterone levels. These favourable may be...
Background: Triple-negative breast cancer (TNBC) with a poor prognosis and survival is the most invasive subtype of cancer. Usually, TNBC requires chemotherapy regimen at all stages, but drugs have shown many side effects. We assumed that combination therapy vinblastine silibinin might reduce toxicity dose vinblastine. Materials Methods: The MDA-MB-231 were cells subjected to MTT assay for IC50 determination effects, which measured based on Chou-Talalay's method. type cell death was...
Abstract Objectives Hypertension, substantially heightens the risk of cardiovascular disease. This study aims to evaluate effectiveness freeze-dried garlic extract in blood pressure and lipid profiles prehypertensive individuals. Methods Participants (age 30–70 years) were allocated intervention (n=47) or control (n=49) groups. The group received two capsules daily for eight weeks, while identical placebo capsules. Primary outcomes, SBP, DBP, PP, MAP, TC, TG, LDL HDL levels, serum NO...
Triple-negative breast cancer (TNBC) is determined by the absence of ERBB2, estrogen and progesterone receptors’ expression. Cancer vaccines, as novel immunotherapy strategies, have emerged promising tools for treating advanced stage TNBC. The aim this study was to evaluate Carcinoembryonic antigen (CEA), Metadherin (MTDH), Mucin 1 (MUC-1) proteins vaccine candidates against TNBC.In research, a designed TNBC using different immunoinformatics bioinformatics approaches. Effective...
Background: Excessive apoptosis of the pancreatic beta-cell has been associated with type 2 diabetes. Hyperglycemia significantly stimulates islet cell apoptosis. We evaluated role crocin and voluntary exercise on pancreas tissue in type2 diabetic rats. Methods: Animals divided into 5 groups as: control (Con), diabetes (Dia), diabetic-crocin (Dia-Cro), diabetic-voluntary (Dia-Exe), diabetic-crocin-voluntary (Dia-Cro-Exe). Type was induced by high-fat diet (4 weeks) injection streptozotocin...
Abstract Background Triple negative breast cancer is the most invasive subtype and possesses poor prognosis survival. Rho GTPase famil, especially Rac1 participates in a number of signaling events cells with crucial roles malignancy, migration invasion tumor cells. Silibinin, flavonoid antioxidant from milk thistle has attracted attention recent decades for chemoprevention chemotherapy In this study, effect silibinin on capacity MDA-MB-231 cells, highly metastatic human cell line was...
Rheumatoid arthritis is a common chronic inflammatory disease with substantial economic, social, and personal costs. Its pathogenesis multifactorial complex. The ultimate goal of rheumatoid treatment stopping or slowing down the progression. In past two decades, invention new medicines, especially biologic agents, revolutionized management this disease. These agents have been associated an improved prognosis clinical remission, in patients who did not respond to traditional disease-modifying...
Abstract Type 2 diabetes mellitus (T2DM) is one of the most common metabolic disorders worldwide. Recent research has indicated that sodium butyrate (NaB) affects glucose metabolism and exercise an anti‐hyperglycemic effect in diabetes. This study aimed to evaluate effects NaB treadmill on heart angiogenesis through miR‐34a/SIRT1/FOXO1‐HIF‐1α pathway. Diabetic animals received (400 mg/kg daily, orally) for 6 weeks. The exercise, alone or combined, miR‐34a expression, SIRT1, FOXO1, HIF‐1α...
Objective Low levels of testosterone in men with diabetes are associated cardiovascular complications. We investigated the effect and voluntary exercise on heart angiogenesis castrated diabetic rats. Methods Sixty-three rats were treated 2 mg/kg/day or alone combination these two for 6 weeks. At end study, tissue samples collected used CD31 detection by immunohistochemical method determination miR-132 levels. Results higher after administration group Combination had synergistic level. In...
Oxidative stress, has been shown to play an important role in the pathophysiology of cardiac remodelling and heart failure. The aim study is effect arginine vasopressin (AVP) on apoptosis cardiomyocyte via its receptors.The cell viability AVP H9C2 cardiomyocytes was assayed using MTT method. transcription translation level genes (Bax, Bcl-2, caspase-3) were discovered with qRT-PCR western blotting.The results showed that could reduce line through downregulation caspase-3, BAX upregulation...
Background: As one of the major complications diabetes, cardiovascular disease might result in early death people with diabetes. miR-126 and 210 expressions undergo alterations cardiac cause heart failure. Methods: Animals were divided into 5 groups control (Con), diabetes (Dia), diabeticcrocin (Dia-Cro), diabetic-voluntary exercise (Dia-Exe), diabetic-crocin-voluntary (Dia-Cro-Exe). Type 2 was induced by use a high-fat diet (4 weeks) injection streptozotocin (STZ) (i.p, 35 mg/kg). received...
signalling.Animals were divided into 4 groups as follows: diabetes (Dia), diabetic-crocin (Dia-Cro), diabetic-voluntary exercise (Dia-Exe), diabetic-crocin-voluntary (Dia-Cro-Exe). Type 2 was induced by high-fat diet (4 weeks) and injection of streptozotocin (STZ) (i.p., 35 mg/kg). Animals received crocin orally (50 mg/kg), voluntary performed alone or together with for 8 weeks. Akt ERK1/2 levels measured ELISA CD31 detected immunohistochemistry.Akt in significantly higher than diabetic...