This study aimed to clarify how macrophages affect prognosis in cancer colon and their association with tumor angiogenesis.Forty four biopsies of carcinoma 15 benign adenomatous polyps were investigated for infiltration microvessels density using immunohistochemistry image morphometric analysis. Macrophages blood vessels stained immunohistochemically by CD68 F-VIII markers respectively. The analysis was carried out on the slides Leica Qwin 500 Image Analyzer. Both correlated histological...

The present study was designed to evaluate the protective effects of echinochrome (Ech) on intrahepatic cholestasis in rats induced by a single (i.p.) injection alpha-naphthylisothiocyanate (ANIT) (75 mg/kg body weight). were pre-treated orally for 48hr (one dose / 24hr) with Ech (1, 5 and 10 weight) or ursodeoxycholic acid (UDCA) 80 weight drug then, injected ANIT. ANIT markedly increased serum activities alanine amino transaminase (ALT), aspartate (AST) alkaline phosphatase (ALP), which...

S100B protein was reported to be elevated in psoriatic patients' serum, with no previous evaluation of its skin expression, contrast the extensively studied S100 protein.To evaluate serum level and expression psoriasis assess possible involvement pathogenesis.Serum estimated 40 patients different clinical varieties 10 healthy controls. assessed immunohistochemically lesional non-lesional normal Relation disease severity also evaluated.Serum significantly higher (0.15±0.03 µg/l) than controls...

Globally, ethical issues in research are becoming of major importance, being well established developed countries with little information about ethics committees (RECs) Africa to assess whether these actually improving the protection human participants.To describe establishment, structure, function, operations and outcome Medical Research Ethics Committee (MREC) National Center (NRC) Egypt from 2003 2011.The committee its regulatory rules for animal based on Declaration Helsinki 2000-2008...

Abstract The work indicates the link between serum cholesterol, atherosclerosis and certain metal metabolism. 122 adult albino rats were used in this study classified into 5 groups: Control group, 29 fed stock diet; group I, 32 diet with 1 % cholesterol for 6 weeks; II, 36 8 III A , 17 0.2 ml oil/day orally weeks B 18 oil daily (50 mg cholesterol/1 oil) weeks. results obtained showed that: 1. positive correlation was found total copper, cadmium Cd/Zn ratio, whereas a negative occurred Zinc...

Background/aim Colorectal cancer is the third malignancy worldwide with high mortality. The development of colorectal carcinoma a multiple step process that turns normal cells into malignant ones. One these steps inhibiting apoptosis. Bcl-2 key regulators apoptosis and thus inhibits programmed cell death. relationship between death proliferation balanced through This study aimed to evaluate immunohistochemical bcl-2 expression, nuclear morphometric parameters, cycle values in premalignant...

BackgroundThyroid nodules are frequently seen in the general population. Preoperative discrimination between benign and malignant is essential to avoid unnecessary surgery. Fine-needle aspiration cytology has greatly improved clinical management of thyroid nodules. Follicular neoplasms,

AIM: This study aimed to investigate the value of DNA ploidy and galectins-3 immunostain in preoperative evaluation thyroid epithelial lesions.MATERIAL AND METHODS: Sixty patients presenting with enlargement were included this referred by clinicians for FNA. Routine cytological was done on PAPÂ Â stained slides according WHO criteria at least three prepared routine examinations. The nuclear analysis performed Pathology Department, National Research Center using Leica Qwin 500 Image Analyzer...

AIM: This study aimed to investigate the value of DNA ploidy and galectins-3 immunostain in preoperative evaluation thyroid epithelial lesions. MATERIAL AND METHODS: Sixty patients presenting with enlargement were included this referred by clinicians for FNA. Routine cytological was done on PAP   stained slides according WHO criteria at least three prepared routine examinations. The nuclear analysis performed Pathology Department, National Research Center using Leica Qwin 500 Image Analyzer...

Objective This work aimed to assess chronic hepatitis C virus-induced liver fibrosis using image analysis and study the relation between cyclooxygenase-2 (COX-2) expression extent of fibrosis. Patients methods Forty-two cases hepatic were included in this study. The Ishak system was used evaluate stage area% for each biopsy specimen calculated Leica-Qwin 500 analyzer. COX-2 investigated immunohistochemically streptavidin–biotin technique. Results Twenty-one high-fibrosis 21 low A significant...

Objective: The present study aimed to investigate the pattern of expression transforming growth factor & (TGF-&) and epidermal receptor (EGFR) in oral squamous cell carcinoma (OSCC) correlate their with tumor grading. Methods:' ( ') ) Results:For both markers, positive staining reaction was characterized by cytoplasmic or membranous staining.EGFR expre' particularly strong at margin invading cords nests tumour cells poorly differentiated malignant cells.The markers significantly correlated...

The purpose of this article is to overview the status health research ethics in Morocco and NA countries, with reference other Middle Eastern countries. EU Migrants: Health Systems project (EUNAM) has supported revision by holding meetings discussions collect information about committees Egypt, revising structure guidelines committees, as well reviewing literature concerning activities concerned This revealed that although efforts regarding countries need be enhanced, form establishment more...