A5061370531- Medicinal Plant Research
- Natural Antidiabetic Agents Studies
- Tea Polyphenols and Effects
- Natural Compound Pharmacology Studies
- Microbial Metabolites in Food Biotechnology
- Nutrition, Genetics, and Disease
- Diverse Scientific Research Studies
- Agricultural and Biological Research
- Moringa oleifera research and applications
- Curcumin's Biomedical Applications
- Phytochemicals and Antioxidant Activities
- Food Quality and Safety Studies
- Biochemical effects in animals
- Phytoestrogen effects and research
- Computational Drug Discovery Methods
- Skin Protection and Aging
- Diet, Metabolism, and Disease
- Food composition and properties
- Carbohydrate Chemistry and Synthesis
- Antioxidant Activity and Oxidative Stress
- Healthcare Quality and Satisfaction
- Papaya Research and Applications
- Seaweed-derived Bioactive Compounds
- Pomegranate: compositions and health benefits
- Chronic Kidney Disease and Diabetes
Maranatha Christian University
2014-2024
Many diseases correlate with antioxidant deficiencies. Garcinia mangostana L rind (GMR) belong to waste product, contains xanthones which are compounds. The aim of this study was determine properties its ethanolic extract, hexane, ethylacetate, butanol, and water fractions in DPPH scavengingactivity, level SOD total (TAS) compared against α-mangostin. Extract all these had high trapping activity while α-mangostin low activity. Level highest GMR fraction TAS ethylacetate fraction. It...
Chronic kidney disease (CKD) happens due to decreasing function. Inflammation and oxidative stress have been shown result in the progression of CKD. Quercetin is widely known various bioactivities including antioxidant, anticancer, anti-inflammatory activities.To evaluate activity quercetin inhibit inflammation, oxidative, fibrosis on CKD cells model (mouse mesangial induced by glucose).The SV40 MES 13 were plated a 6-well plate with cell density at 5,000 cells/well. The medium had...
Background Oxidative stress caused by exposure to ultraviolet (UV) light on the skin can damage deoxyribonucleic acid (DNA) and cause keratinocytes undergo apoptosis. Endogenous antioxidants which play a role in trapping free radicals are also unable overcome excess reactive oxygen species (ROS) body due UV exposure, so exogenous needed. Polyphenolic compounds extracted from natural ingredients such as flavonoids, quercetin, epicatechin have quite strong antioxidant activity. This is...
Diabetic nephropathy (DN) is a chronic kidney failure, which may lead to fatality. Mesangial cell proliferation, renal inflammation, stress oxidative, and fibrosis are involved in DN progression. Yacon leaves (Smallanthus sonchifolius (Poepp.) H. Rob.) contains large amounts of phenolic compounds it has the ability inhibit oxidative stress, fibrosis. Considering potential yacon extract (YLE), be used for treatment. This research aimed elucidate YLE's as anti-DN through anti-inflammatory,...
Background: Adipocytes accumulate triacylglycerol when excessive food consumption. Adipocyte dysfunction plays an important role in the obesity development. People with a body weight 40 % heavier than average population at risk of death two times greater weight. The use anti-obesity drugs have many side effects, so it is necessary to find drug low toxicity. This ex vivo study was conducted determine activity C. longa L. extract inhibiting triglycerides and cholesterol synthesis lipid droplet...
Aims: This research was performed to evaluate the antioxidant and anti malarial activities of various catechins including catechin (C), epicatechin (EC), catechin-gallate (CG), gallocatechingallate (GCG), epigallocatechin (EGC), epicatechin-gallate (ECG), gallate (EGCG). Study Design: The activity measured by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) scavenging anti-malarial determined In vitro assay against P. falciparum culture, analyzed using linear regression analysis, continued determining...
Helminths infections caused by Soil-Transmitted (STH) are found in manypeople living developing countries, especially rural areas. People often use pomegranate asan anthelmintic. The aim of this research is to find out the effects peel (Punicagranatum L.) as an anthelmintic female Ascaris suum vitro. on ofpomegranate extract has been conducted 900 suumare divided into 5 groups, group I: dose 25%, II: pomegranatepeel 50%, III: 75%, IV: 0.9% NaCl anegative control, and V given mebendazole 0.5%...
Diabetes Mellitus (DM) is a chronic disease caused by genetics, lifestyle, and immunology. Type 2 DM resistanceto insulin, which causes blood sugar to not be stored in glycogen. Clitoria ternatea L. (Fabaceae) flower contains lot ofanthocyanins has long been used various traditional medicines. They are believed treat fever, inflammation, anddiabetes. Anthocyanins have antidiabetic, anticancer, anti-inflammatory, anticancer properties. This study aimed toevaluate anti-DM of extract (CTE)...
Metabolic abnormalities caused by the accumulation of human, environmental, genetic and lifestyle variables can be found in diabetes mellitus (DM). An increase blood glucose carried on a reduction insulin production also result DM. Insulin resistance often occurs as obesity lack physical activity aging. Telang flower extract (Clitoria ternatea L.) is reported to have several qualities such being able treat DM, chronic bronchitis, goiter, mucosal disorders leprosy. This study’s objective was...
Introduction: Diabetes mellitus (DM) is a chronic condition with free radicals and carbohydrate-hydrolyzing enzymes playing key roles in its progression. Yacon or Smallanthus sonchifolius (Poepp.) H.Rob, low-sugar crop, has shown promising bioactivities. This research aimed to explore the antidiabetic antioxidant potential of yacon tuber extract (YTE). Methods: YTE’s enzyme inhibitory activities were assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) at concentrations 6.25, 12.5, 25, 50,...
Drug resistance to malaria is still a problem in various regions, and there have even been developments the ACTs (artemisinin-based combination therapies) as standard antimalarial drugs included artemisinin's partner drugs. Ethyl acetate fraction of G. mangostana L rind, containing xanthones an antioxidant, has activity vitro which synergistic effect with artemisinin. That's why activities this are needed be studied vivo.To explore antioxidant ethyl Garcinia rind mice.This was complete...
Background: Diabetes is a chronic disease characterized by glucose levels and results in impaired insulin secretion. This disorder has triggered oxidative stress excess free radicals condition. Smallanthus sonchifolius traditional medicine that acts as diabetic therapy. research aims to bring out the antidiabetic antioxidant potential of S. extract (SSE). Materials Methods: study was conducted measure qualitative phytochemical identification, anti-diabetic activity SSE. The assay carried...
To overcome malarial resistance tendency against the ACT (artemisinin-based combination therapy), several galenic preparations of Garciniamangostana L-rind and alphamangostin as major xanthone in this rind have been studied, they had antimalarial activity showed its synergistic effect with artemisinin vitro. Curcumin anactive component turmeric is also potentially to activity. This study aimed evaluate curcumin dihydroartemisinin, an active metabolite all derivates, mechanism action...
Lymphatic filariasis is a mosquito borne disease, transmitted by mosquitoes such as Culex , Anopheles Aedes Mansonia . Filariasis infection resulting in disability. The important method to avoid being bitten from using repellent. purpose of this study were compare repellency duration citronella oil lotion against sp. and its N,N-diethyl-m-toluamide (DEET). Laboratory experimental design was conducted at each five men subjects randomly treatments: 20%, 40% (COL), base (negative control),...
Ascariasis is known as "soil transmitted helminths" which persons were infected by ingesting eggs passed in the feces.The most prevalence of school children are more than 30%, with resultant impairment growth retardation, intellectual, and cognitive development.The purpose this research was to determine anthelminthic effectivity Gandarusa Leaves Infusion (GLI), Kapuk Seed (KSI) same pyrantelpamoat against female Ascarissuum vitro.Methods true laboratory experimental, using 1200 worms...
Abstract Drug discovery effort need to be done because of the malaria drug resistance evidence. Against available ACTs, this also started develop. Alphamangostin has antimalarial activity and synergistic effect with dihydroartemisinin. The aim study was look for optimum ratio combination as antimalaria lowest IC 50 (the most active) smallest Sum FIC effect). Three kinds stock solution alphamangostin dihydroartemisinin were made consisting of: 1) a half dihydroartemisinin, 2) quarter 3) three...