Skin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) a phenolic compound which known for its antioxidant properties against oxidative stress.This study investigates antiaging anti-inflammatory of CA on UV-induced skin fibroblast cells.Anti-inflammatory were assessed measuring inflammatory-related proteins IL-1β TNF-α, while reactive oxygen species (ROS), apoptosis, live necrotic cells,...

Prolonged exposure of free radicals, or known as reactive oxygen species (ROS), in hepatic cells may cause oxidative stress. Without proper treatment, it can induce liver injury and fatal disease, including cirrhosis. Red betel (Piper crocatum Ruiz Pav) is one Indonesia's medicinal plants that has been to exhibit antioxidant, anti-inflammatory activities. This study aims determine hepatoprotective effect red leaves extract (RBLE) towards injury.Hydrogen peroxide-induced HepG2 were used...

Aging is a complicated process occurring due to the combination of incremental alterations skin and accumulated extrinsic factors that causes both structural functional disruptions. The factor aging mostly caused by free radicals, UV exposures, pollution. Prevention possible escalating antioxidant intake scavenge ROS in process. Rutin caffeic acid are recognized for their radical trapping effects reported have potential antiaging activities. This study aimed identify potentials rutin as...

Skin aging is a complex natural process characterised by gradual diminishment of structural integrity and physiological imbalance the skin tissue. Since oxidative stress tightly corelated to process, usage antioxidant may serve as favourable strategies for slowing down process. Mangosteen an important fruit commodity its extract had been extensively studied revealing various biological activities. Present study aimed assess antiaging activity mangosteen peel (MPE) phytochemical compounds....

The National Health Insurance Program is an effort made by the government to support comprehensive health development and has goal of ensuring that Indonesian population gets their right health. According data obtained from BPJS Kesehatan with Murni Teguh Medan Hospital, it was found average waiting time for polyclinic services exceeded national quality indicator, where outpatient treatment did not exceed 60 minutes. Polyclinics some oncology specialties are still past expected limits,...

Electronic cigarette (e-cigarette) use has rapidly increased among adolescents, raising concerns about its impact on oral health. This study investigated the association between e-cigarette and gingival pigmentation adolescents in a community setting. A cross-sectional was conducted November 2024 members of Vapers City Medan community. Data were collected through Google Form questionnaire photographic documentation participants' gingiva. The assessed patterns, including frequency duration,...

Calamus caesius, traditionally used in Asian medicine for managing diabetes mellitus, is a promising source of endophytic bacteria due to its bioactive potential. This study aims identify the potential isolated from “Pakkat” (Calamus caesius Blume), traditional food North Sumatra, as α-glucosidase inhibitors. These inhibitors, such acarbose, are manage type 2 mellitus but have significant gastrointestinal side effects. focuses on isolating and characterizing that can produce natural...

External aging factors such as UV exposure, pollution, and lifestyle choices contribute to skin aging, resulting in deep wrinkles, fine lines, rough skin, which can lower self-confidence. Plant extracts have been widely studied for their antiaging potential, while Salmon DNA has shown promise stimulating collagen production. This study explores the formulation of a serum combining Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, its effects on injured human fibroblast cells. The...

Aging is a skin phenomenon that caused intrinsically by tissue degeneration and extrinsically environmental toxicity including ultraviolet (UV) exposure, manifested as wrinkles damage respectively. Chlorogenic acid (CA) possesses roles antiinflammation antioxidation reducing reactive oxygen species (ROS). The present study examined CA anti-aging activities toward fibroblast (BJ) cells induced UV. Antiaging properties of were analyzed assessing the levels collagen-1α1 (COL-1α1), elastin...

Prevention of osteoporosis at a young age is very necessary. Evidence suggests that modifying some lifestyle habits can help reduce the incidence osteoporosis. However, limited research has been conducted to assess knowledge, attitudes, and lifestyles related among people. Good knowledge attitude towards will result in real prevention actions. Therefore, this study aims evaluate attitudes practices about group students.This was using an analytical observational method cross-sectional design....

Background: The pain experienced by Nucleus Pulposus Herniation (NPH) patients can have an impact on productivity and may lead to disability. Therefore, non-pharmacological therapies serve as alternatives in reducing levels for Grade I II NPH patients. Purpose: To compare the difference effectiveness between Infrared-Transcutaneous Electrical Nerve Stimulation (IR-TENS) combination Proprioceptive Neuromuscular Facilitation (PNF) among Method: This research employed a quasi-experimental...

Exposure to ultraviolet-B (UV-B) light contributes a decrease in skin collagen levels, which can cause premature aging. This study aims evaluate the effectiveness of telang flower (Clitoria ternatea L.) extract lotion maintaining levels and epidermal thickness UV-B-exposed rat skin. A total 30 Wistar male white rats (200-250 g) were divided into six treatment groups: negative control (distilled water), positive (Vaseline), four groups with concentrations 0.2, 0.5, 0.75, 1%. Mice exposed UV-B...

Penuaan kulit merupakan proses alami yang tidak dapat dihindari oleh setiap individu. Proses penuaan ini dipengaruhi secara intrinsik maupun ekstrinsik. Faktor ekstrinsik berlebih memberikan pengaruh signifikan pada kesehatan kulit. Di saat bersamaan, sejumlah masyarakat belum mengetahui pentingnya menjaga kualitas Maka dari itu, bersama dengan Universitas Kristen Maranatha, diselenggarakan penyuluhan untuk meningkatkan kesadaran penjagaan hingga memperoleh optimal. Kegiatan juga dilengkapi...

Background: Diabetes mellitus (DM) is a global health challenge with severe burden. Approximately 40% of diabetic patients develop kidney disease (DKD), leading to failure. Autologous dendritic cell therapy may enhance renal function by modulating vascular markers. Methods: Involving 35 patients, this quasi-experimental study assessed the pulsatility index (PI), resistive (RI), endothelial growth factor (VEGF), and endothelin levels before four weeks following autologous administration....

This study examines the relationship between Hospital Healthcare Service Quality (HCSQ) and patient loyalty at Tgk. Chik Ditiro Sigli Regional General Hospital, with a focus on mediating role of satisfaction influence leadership styles. Employing qualitative approach, data were collected through in-depth interviews, group discussions, document analysis to capture perspectives patients, healthcare professionals, hospital administrators. The findings reveal that key dimensions HCSQ—such as...

This study examines the relationship between leadership styles of nurse managers, job satisfaction, organizational commitment, and their combined influence on performance in Pidie Jaya Regional General Hospital. Using a qualitative approach, research explores how transformational transactional affect outcomes through mediating variables satisfaction commitment. The findings contribute to understanding dynamics effective nursing improving healthcare delivery.

Background: Type 2 diabetes mellitus is a global health problem with increasing prevalence, especially in urban areas. Management of the disease requires patient self-awareness factors such as physical activity, balanced diet, stress control, and medication adherence. Purpose: To analyze influence adherence on patients' behavior controlling blood sugar levels communities Riau Province. Method: Quantitative research cross-sectional design involved 105 respondents aged 40-65 years who were...

Background: Skin aging is a condition where skin unable to retain both its physiological and structural integrity. Plants the main source of phtytochemicals compound with wide range biological activities. Through efforts ongoing scientific researches, an increasing number plant extracts phytochemicals have been showed promising result as anti-aging agent. Snake fruit (Salacca zalacca (Gaert.) Voss) tropical belongs palm tree family (Arecaceae) that served important crop in Indonesia. Despite...

Background: The excessive free radicals condition called oxidative stress can harmful for the body. To prevent and cure it, antioxidant agents are required. Nowadays, natural product extracted from plants have been widely used in folk medicine as treatment of many diseases. Ficus elastica (rubber tree) has some compounds that several biological activities, i.e., quercitrin, myricitrin, morin, eleutheroside B. F. works against be potential agent. purpose this study was to evaluate properties...

Lead (Pb) can be a cause of oxidative stress, because it is toxin found in the environment and have harmful effect on body. increased reactive oxygen species (ROS) nitrogen (RONS) levels cellular aging inflammation. natural compound plant one sources antioxidant anti-inflammatory agent that has ability to prevent including chlorogenic acid (CA). Cytotoxicity assay CA against fibroblast cells (BJ) was conducted using MTS...

Acetaminophen (APAP) is a widely used analgesic, but it may cause liver injury (hepatotoxicity) via oxidative stress that induced by N-acetyl-p-benzoquinone imine (NAPQI) in long term usage or overdose. Multiple inflammatory mediators were also found to contribute for this effect. Many medicinal plants was known its antioxidant and anti-inflammatory activities one of them Red betel (Piper crocatum Ruiz Pav) from Indonesia. In study, the red leaves extract (RBLE) protective effect against...