Prolonged exposure of free radicals, or known as reactive oxygen species (ROS), in hepatic cells may cause oxidative stress. Without proper treatment, it can induce liver injury and fatal disease, including cirrhosis. Red betel (Piper crocatum Ruiz Pav) is one Indonesia's medicinal plants that has been to exhibit antioxidant, anti-inflammatory activities. This study aims determine hepatoprotective effect red leaves extract (RBLE) towards injury.Hydrogen peroxide-induced HepG2 were used...

Aging is a complicated process occurring due to the combination of incremental alterations skin and accumulated extrinsic factors that causes both structural functional disruptions. The factor aging mostly caused by free radicals, UV exposures, pollution. Prevention possible escalating antioxidant intake scavenge ROS in process. Rutin caffeic acid are recognized for their radical trapping effects reported have potential antiaging activities. This study aimed identify potentials rutin as...

The quality of health services is an essential factor in creating patient satisfaction and trust facilities. Puskesmas, as a critical service, plays central role meeting the community's needs, especially remote areas such Sei Berombang Labuhanbatu. However, challenges faced by Puskesmas providing adequate often lead to variations levels. Lack resources infrastructure are barriers improving service quality. This study aims analyze effect dimensions on at 2024. method used was quantitative...

Abstract: Background: The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide, leading to a higher diabetic kidney disease (DKD). DKD has increased inflammation and decreased function. Patients have not received op-timal therapy. This study aims see the effect autologous dendritic cell administra-tion on DTI MRI examination biomarkers Matrix Metalloproteinase-9 (MMP-9) Intercellular Adhesion Molecule-1 (ICAM-1). Methods: An open-label clinical trial was conducted 25...

In the digital era, integration of quality and routine data is key to transforming healthcare services. The utilization information technology continues grow, spanning from planning providing individual community health data. One innovations implemented transition manual medical records electronic (RME), which despite its many benefits, still faces various challenges. RSU Royal Prima Medan started this process at end 2023 until early 2024, with main obstacles being infrastructure...

Background: Type 2 diabetes mellitus (DM) is a chronic disease that continues to increase globally, with significant health and economic burden. A balanced diet key component of type DM management. Purpose: To analyze the factors influence behavior in patients Pekanbaru using Theory Planned Behavior (TPB) approach. Method: This study used quantitative method cross-sectional design. Data were collected from 117 who registered at Health Center. The variables studied included knowledge,...

Background: Skin aging is a condition where skin unable to retain both its physiological and structural integrity. Plants the main source of phtytochemicals compound with wide range biological activities. Through efforts ongoing scientific researches, an increasing number plant extracts phytochemicals have been showed promising result as anti-aging agent. Snake fruit (Salacca zalacca (Gaert.) Voss) tropical belongs palm tree family (Arecaceae) that served important crop in Indonesia. Despite...

Background: The excessive free radicals condition called oxidative stress can harmful for the body. To prevent and cure it, antioxidant agents are required. Nowadays, natural product extracted from plants have been widely used in folk medicine as treatment of many diseases. Ficus elastica (rubber tree) has some compounds that several biological activities, i.e., quercitrin, myricitrin, morin, eleutheroside B. F. works against be potential agent. purpose this study was to evaluate properties...

Acetaminophen (APAP) is a widely used analgesic, but it may cause liver injury (hepatotoxicity) via oxidative stress that induced by N-acetyl-p-benzoquinone imine (NAPQI) in long term usage or overdose. Multiple inflammatory mediators were also found to contribute for this effect. Many medicinal plants was known its antioxidant and anti-inflammatory activities one of them Red betel (Piper crocatum Ruiz Pav) from Indonesia. In study, the red leaves extract (RBLE) protective effect against...

Skin aging is a complicated natural phenomenon characterized by progressive loss of structural integrity and physiological function the skin. Snake fruit (Salacca zalacca) an important crop native from Indonesia. Its waste potential sour.

Background: Skin aging is a complex natural process caused by both intrinsic or genetically programmed and extrinsic environmental factors, such as free radical. The use of antioxidant anti-collagenase to prevent the proses has been known. Natural compounds from plants are one sources that ability aging. Genistein Epicatechin major phenolic compound found in G. max. Objectives: This research was evaluate antiaging potential genistein epicatechin through activity assay (ABTS-reducing assay)...

Background: Skin-aging is a progressive changes in the skin combine with cumulative extrinsic factors which are mostly caused by free radicals exposure to lots of molecules from pollutant, wrongly food intake, or too much sun bathing. These can be tackled treatment using antioxidants. Prevention aging done escalating antioxidant intake. Protocatechuic acid (PCA) and Ferulic (FA) have been known for their scavenging properties on antiaging activity. Antioxidant activity both compounds not...

Abstract. Nasution SA, Fachrial E, Ginting CN, Liena, Piska F. 2023. Bacteriocin-producing Pediococcus acidilactici BAMA 15 isolated from "naniura" traditional foods in North Sumatra, Indonesia. Biodiversitas 24: 2830-2835. Lactic Acid Bacteria (LAB) have beneficial properties for their hosts, potentially promoting health and balancing the normal gut flora. Meanwhile, bacteriocin is a bacteriostatic polypeptide used as food preservative. LAB are generally produced fermented products, such...

Free radicals can cause damage to cells or tissues, autoimmune diseases, degenerative cancer. Therefore, the body needs important substances, namely antioxidants that help protect by reducing negative effect from free radicals. Rose flower (Rosa damascena) has anthocyanin pigment which belongs flavonoid group a function as antioxidant radical scavenger. This study aims determine and anti-elastase potentials of rose petals receptacles. The method used in this was qualitative phytochemical...

This study provides a conceptual and empirical investigation of the effect items on measuring quality post-COVID-19 health services based patient perceptions in sector. The proposed measurement item for Consumer Perceived Value Healthcare (CPV Healthcare) against Service Quality (HEALTHQUAL) was tested using data collected from hospital Medan City 253 respondents. set included 185 patients 68 respondents public June 2022 to November 2022. research is associative quantitative method approach....

Liver injury occurs due to continuous exposure chemical or biological hazards.Eugenol (EUG), a phenolic compound derived from red betel (Piper crocatum) leaves, has multivalent effects, primarily on antioxidant and antibacterial applications.The conducted research sought investigate the safeguarding activities of EUG hydrogen peroxide (H2O2)-induced toxicity human liver HepG2 cells by examining homeostasis, interleukin 10 (IL-10), malondialdehyde (MDA) levels, reactive oxygen species (ROS)...

Background: Vernonia amygdalina, commonly known as bitter leaf, has been traditionally used for its potential antidiabetic properties. This study aimed to evaluate the therapeutic of amygdalina extract (VAE) in ameliorating hyperglycemia using a streptozotocin (STZ) and high-fat diet (HFD)-induced rat model diabetes. Methods: Sixty male Wistar rats were divided into six groups: normal control, diabetic four treatment groups receiving different doses VAE (100, 300, 500 mg/kg body weight)...

Acne vulgaris is an inflammatory disorder of the pilosebaceous unit, characterized by lesions such as comedones, papules, pustules, nodules, and cysts. This study aimed to assess effectiveness Andaliman Extract Nanoemulgel (Zanthoxylum Acanthopodium DC) in treating acne male Wistar rats (Rattus Novergicus) induced with Propionibacterium acnes. experimental involved 30 aged 6-8 weeks, weighing 150-200 grams, divided into 6 groups: 1) normal, 2) negative control (P. acnes induction base gel),...

Diabetes mellitus is usually associated with oxidative stress which can initiate or promote chronic diabetic lesions in various organs. Reactive Oxygen Species accumulation affects liver tissue and may also cause Non-Alcoholic Fatty Liver Disease (NAFLD). Lemon pepper an alternative medicine that widely used the Batak community. Therefore, this study was designed to determine improvement of function from ethanolic extract lemon (Zanthoxylum acanthopodium) Wistar rats induced by...

In 1991 and 1992, Gilbertella persicaria was more common than Rhizopus spp. on rotted peaches found the orchard floor in major peach production areas of South Carolina. G. isolated frequently from soil surface organic debris commercial orchards five counties. were much less these sources. Also, commonly along with collected harvest bins before during harvest, hydrocooling water dump tank water, packing line belts. Dicloran iprodione both active vitro to inhibit growth mycelium, but...

Abstract Imbalance in liver metabolism lead to oxidative stress mainly caused by free radicals or termed as reactive oxygen (ROS). Prolonged ROS exposure without proper treatment induce severe damage and serious hepatic diseases including cirrhosis. Eugenol (4-allyl 2-methoxyphenol) is phenolic derivative compound that showed antioxidant, anti-inflammatory, analgesic, antibacterial, antifungal, antitumor activities. This study aims evaluate the hepatoprotective effect of eugenol through...