A5008912182- Forensic Toxicology and Drug Analysis
- Cannabis and Cannabinoid Research
- Psychedelics and Drug Studies
- Neurotransmitter Receptor Influence on Behavior
- Alcohol Consumption and Health Effects
- Poisoning and overdose treatments
- Carcinogens and Genotoxicity Assessment
- Cardiovascular Syncope and Autonomic Disorders
- Amino Acid Enzymes and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Advanced Chemical Sensor Technologies
- GABA and Rice Research
- Intravenous Infusion Technology and Safety
- Electrohydrodynamics and Fluid Dynamics
- Biomedical and Chemical Research
- Nicotinic Acetylcholine Receptors Study
- Treatment of Major Depression
University of St. Gallen
2019-2024
University of Freiburg
2013-2023
University Medical Center Freiburg
2013-2023
Kantonsspital St. Gallen
2022
Institute of Forensic Science
2016
Indole or indazole‐based synthetic cannabinoids (SCs) bearing substituents derived from valine tert ‐leucine are frequently abused new psychoactive substances (NPS). The emergence of 5F–MDMB‐PICA (methyl N ‐{[1‐(5‐fluoropentyl)‐1 H –indol‐3‐yl]carbonyl}‐3‐methylvalinate) on the German drug market is a further example substance synthesized in context scientific research being misused by clandestine laboratories adding it to ‘legal high’ products. In this work, we present detection several...
Among the recently emerged synthetic cannabinoids, MDMB-CHMICA (methyl N-{[1-(cyclohexylmethyl)-1H-indol-3-yl]carbonyl}-3-methylvalinate) shows an extraordinarily high prevalence in intoxication cases, necessitating analytical methods capable of detecting drug uptake. In this study, vivo phase I metabolism was investigated using liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) and ionization-quadrupole time-of-flight-mass (LC-ESI-Q ToF-MS) techniques. The...
Introduction: In 2014, the "European Monitoring Centre for Drugs and Drug Addiction" (EMCDDA) reported on 30 novel synthetic cannabinoids (SCs). Among these were indole- indazole-based valine derivatives with a cyclohexylmethyl side chain (e.g., AB-CHMINACA MDMB-CHMICA), which represent new class of SCs.Methods: A prospective observational study patients treated in emergency departments (EDs) after intake SCs was conducted. Clinical laboratory data combined to poison control centre. Serum...
Abstract Background: The abuse of synthetic cannabinoids (SCs) as presumed legal alternative to cannabis poses a great risk public health. For economic reasons many laboratories use immunoassays (IAs) screen for these substances in urine. However, the structural diversity and high potency designer drugs places demands on IAs regarding cross-reactivity antibodies used detection limits. Methods: Two retrospective studies were carried out order evaluate capability two homogenous enzyme...
Since 2009, more than 140 different synthetic cannabinoids (SC) have been identified in herbal mixtures consumed as recreational drugs. Knowledge of the acute toxicity each individual compound remains sparse. Here we present a retrospective observational case series patients presenting to emergency departments with analytically confirmed intake JWH‐210 only SC detected serum samples. Cases were selected from poison centre database March 2011 June 2014. In total, 22 included (aged 12–25...
Synthetic cannabinoid receptor agonists (SCRAs, "Spice") are a diverse group of recreational drugs, with their structural and pharmacological variability still evolving. Forensic toxicologists often rely on previous reports to assess role in intoxication cases. This work provides detailed information the "Spice"-related fatalities around Munich, Germany, from 2014 2020. All cases underwent an autopsy. Pharmaceutical illicit drugs were detected quantified post-mortem peripheral blood or liver...
Background: New psychoactive substances (NPS) have become increasingly prevalent and are sold in internet shops as 'bath salts' or 'research chemicals' comprehensive bioanalytical methods needed for their detection. Methodology: We developed validated a method using LC MS/MS to quantify 56 NPS blood urine, including amphetamine derivatives, 2C compounds, aminoindanes, cathinones, piperazines, tryptamines, dissociatives others. Instrumentation included Synergi Polar-RP column (Phenomenex)...
The number of new psychoactive substances (NPS) that have emerged on the European market has been rapidly growing in recent years, with a particularly high compounds from group synthetic cannabinoid receptor agonists. There various political efforts to control trade and use NPS worldwide. In Germany, Act distribution (NpSG) came into force November 2016. this act, two groups were defined, “cannabimimetics/synthetic cannabinoids” covering indole, indazole, benzimidazole core structures,...
In recent years e-liquids used in electronic cigarettes have become an attractive alternative to smoking tobacco. A new trend is the use of containing synthetic cannabinoids (SCs) instead cannabis or herbal mixtures laced with SCs. frame a systematic monitoring online market 'legal high' products, from retailers who also sell blends were bought.The products analyzed by gas chromatography-mass spectrometry. some unknown compound was detected which identified as SC 5F-Cumyl-PINACA...
Objective: The potent hallucinogenic drug 25I-NBOMe has recently emerged on the market. We present a case with analytically confirmed intoxication from prospective study "SPICE II Plus".Case report: Because of severe headache 42-year-old man took one sip pediatric analgesic syrup, which had been refilled self-made solution in ethanol. Thirty minutes later restlessness occurred. On arrival emergency department mydriasis, strong sweating, disorientation, and agitation were noticed. Within...
Recently, the pyrazole‐containing synthetic cannabinoid N ‐(1‐amino‐3‐methyl‐1‐oxobutan‐2‐yl)‐1‐(cyclohexylmethyl)‐3‐(4‐fluorophenyl)‐1 H ‐pyrazole‐5‐carboxamide (3,5‐AB‐CHMFUPPYCA) has been identified as a ‘research chemical’ both in powdered form and an adulterant present herbal preparations. Urine is most common matrix used for abstinence control extensive metabolism of cannabinoids requires implementation targeted analysis. The study describes investigation vitro phase I...
Abstract The number of newly appearing benzodiazepine derivatives on the new psychoactive substances (NPS) drug market has increased over last couple years totaling 23 ‘designer benzodiazepines’ monitored at end 2017 by European Monitoring Centre for Drugs and Drug Addiction. In present study, three benzodiazepines [flunitrazolam, norflurazepam, 4′‐chlorodiazepam (Ro5–4864)] offered as ‘research chemicals' Internet were characterized their main in vitro phase I metabolites tentatively...
Aim of this study was the investigation genotoxic properties XLR-11 [1-(5-fluoropentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone, a widely consumed synthetic cannabinoid (SC), and benzoyl indole RCS-4 (4-methoxyphenyl)(1-pentyl-1H-indol-3-yl)methanone). We characterized DNA-damaging these drugs in different experimental systems. No evidence for induction gene mutations detected bacterial (Salmonella/microsome) tests, but clear dose-dependent effects were found vitro single...
Synthetic cannabinoids (SCs) are a structurally diverse class of new psychoactive substances. Most SCs used for recreational purposes based on indole or indazole core structures. EG-018 (naphthalen-1-yl(9-pentyl-9H-carbazol-3-yl)methanone), EG-2201 ((9-(5-fluoropentyl)-9H-carbazol-3-yl)(naphthalen-1-yl)methanone), and MDMB-CHMCZCA (methyl 2-(9-(cyclohexylmethyl)-9H-carbazole-3-carboxamido)-3,3-dimethylbutanoate) 3 representatives structural subclass SCs, characterized by carbazole system. In...
Abstract Pharmaceutical research not only provides the basis for development of new medicinal products but also synthesis drugs abuse. 3‐Fluorophenmetrazine (3‐FPM), a fluorinated derivative anorectic phenmetrazine, was first patented in 2011 and appeared on drug market 2014. Though invented potential medical purposes, pharmacokinetic data this compound, crucial interpreting forensic as well clinical cases, are available. Therefore, liquid chromatography−electrospray ionization−tandem mass...