Non-alcoholic fatty liver disease (NAFLD) is an emerging condition with a worldwide prevalence ranging from 6% to 35% and very frequent among patients obesity, diabetes, or metabolic syndrome. One of the main challenges in treatment this identification reliable direct biomarker diagnose stage hepatic steatosis before it progresses steatohepatitis. This especially important as many remain asymptomatic until cirrhosis develops. The aim study was analyze expression enzyme acetyl-CoA carboxylase...

Phenolic acids are phytochemical compounds derived from plant biomass materials, that have notable health benefits with high therapeutic potential in several diseases. <em>p</em>‑coumaric acid (<em>p</em>‑CA) is a phenolic displays various biological activities, such as antioxidant, anti‑inflammatory, analgesic and anti‑antimicrobial properties. However, the ability of <em>p</em>‑CA to prevent hepatic necrosis cholestasis induced by harmful agents has not yet been explored date, at least...

Amebiasis is a parasitic disease that extends worldwide and public health problem in developing countries. Metronidazole the drug recommended treatment of amebiasis, but its contralateral effects lack continuity induce low efficiency, coupled with appearance resistant amoebic strains. Therefore, search new compounds amoebicidal activity urgent important. In this study, we evaluated vitro vivo antiamoebic essential oil Dysphania ambrosioides (L.) Mosyakin & Clemants. It exhibited an IC50 =...

A molecular characterization of the main phytochemicals and antioxidant activity Opuntia robusta (OR) fruit extract was carried out, as well an evaluation its hepatoprotective effect against diclofenac (DF)-induced acute liver injury evaluated. Phenols, flavonoids betalains were quantified, performed by means ABTS•+, DPPH FRAP assays. UPLC-QTOF-MS/MS used to identify biocompounds present in OR out via. In vivo model, groups rats treated prophylactically with extract, betanin N-acteylcysteine...

Atopic dermatitis (AD) is one of the most common skin diseases, whose incidence increasing in industrialized countries. The epicutaneous application a hapten, such as 2,4-dinitrochlorobenzene (DNCB), evokes an experimental murine AD-like reaction. Glycomacropeptide (GMP) dairy bioactive peptide derived from hydrolysis κ -casein by chymosin action. It has anti-inflammatory, prebiotic, and immunomodulatory effects. present study was aimed to investigate effect GMP administration on...

La colagenasa ii ha sido utilizada para inducir queratocono experimental en modelos animales. Sin embargo, no estudiado su efecto cuando se administra por inyección intraestromal, lo que el propósito de este estudio fue estudiar los efectos la intraestromal sobre superficie corneal y morfología córnea. Se trabajó con 6 conejos Nueva Zelanda, administró (5 μL 2,5 mg/mL) ojos derechos solución salina balanceada izquierdos. realizaron queratometrías evaluar alteración curvatura, también al...

Entamoeba histolytica invades the intestine and other organs during pathogenesis of amoebiasis. In early stages, host organism responds with an inflammatory infiltrate composed mostly neutrophils. It has been reported that these immune cells, activated by E. histolytica, exert a protective role releasing proteolytic enzymes generating reactive oxygen/nitrogen species (ROS/RNS) antimicrobial peptides. is now known neutrophils also produce neutrophil extracellular traps (NETs), which are able...

Activated hepatic stellate cells (aHSCs) are the main effector during liver fibrogenesis. α-1 adrenergic antagonist doxazosin (DX) was shown to be anti-fibrotic in an vivo model of fibrosis (LF), but mechanism remains elucidated. Recent studies suggest that reversion LF can achieved by inducing cellular senescence characterized irreversible cell-cycle arrest and acquisition senescence-associated secretory phenotype (SASP).To elucidate effect DX determine whether it induces senescence.Primary...

The influence of anterior pituitary hormones on the gastrointestinal tract humans and animals has been reported. Hypophysectomy (HYPOX) in rat causes atrophy intestinal mucosa, reduction gastric secretion absorption, increased susceptibility to infections. To our knowledge, there are no studies humoral immune response gut-associated lymphoid tissue after HYPOX. We have reported that decreased vasopressin oxytocin due neurointermediate lobectomy (NIL) diminishes cell-mediated responses....

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; The parasympathetic nervous system modulates the immune response in abdominal-pelvic gut through vagus nerve, which releases acetylcholine. This endogenous ligand acts on a7 nicotinic receptors expressed cells. &lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; To study mechanism of production and regulation cytokines parasympathectomized control hamsters during development amoebic liver abscesses (ALA) caused by &lt;i&gt;Entamoeba...

Liver cirrhosis is the result of an uncontrolled fibrogenetic process, due to activation and subsequent differentiation into myofibroblasts hepatic stellate cells (HSC). It known that HSC express adrenoreceptors (AR), use AR antagonists protects experimental animals from cirrhosis. However, several studies suggest toxicity generated by metabolism these would hinder its in cirrhotic patients. In addition, liver fibrosis may be associated with a decrease antioxidant response nuclear factor...

Entamoeba histolytica trophozoites do interact with extracellular matrix components in order to invade and finally destroy tissue. An important step this interaction involves the binding of a 140‐kDa membrane protein that binds fibronectin. The similarity amoebic receptor fibronectin receptors from higher eukaryotic cells was defined by indirect immunofluorescence, western blot immunohistochemistry. using polyclonal monospecific antibodies raised against protein. These results suggest lower...

We studied the early in situ interactions of live and fixed Entamoeba histolytica trophozoites with hamster hepatic parenchymal inflammatory cells using immunoperoxidase immunoelectronmicroscopy. Close contact between endothelial diffusion amoebic molecules from towards nearby distant hepatocytes were observed. The around amoebae remnants located close to lesion had a positive stain for molecules. In amoebae, at ultrastructural level, attached membranes inside vesicles. These apparently...

Martin Humberto Muñoz-Ortega, Raúl Wiliberto Llamas-Ramírez, Norma Isabel Romero-Delgadillo, Tania Guadalupe Elías-Flores, Edgar de Jesus Tavares-Rodríguez, María del Rosario Campos-Esparza,Daniel Cervantes-García, Luis Muñoz-Fernández, Gerardo-Rodríguez, and Javier Ventura-Juárez. Gut Liver 2016;10:101-8. https://doi.org/10.5009/gnl14459

Liver fibrosis is a chronic disease associated with oxidative stress that has great impact on the population mortality. Due to their antioxidant capacity, we evaluated protective effect of Opuntia robusta fruit (Or) liver fibrosis. A nutraceutical characterization Or was performed and model induced thioacetamide (TAA) in Wistar rats. Aminotransferases, reduced glutathione (GSH) histopathology were evaluated. contained 436.5 ± 57 mg Betacyanins equivalents/L., 793 catechin equivalents...

SUMMARY Amoebic liver abscesses (ALA) are the most frequent and severe extraintestinal clinical presentations of amoebiasis. During early establishment amoebae in parenchyma, as well during extension tissue necrosis, parasites interact with parenchymal cells and, a consequence these interactions, hepatocytes can be destroyed host immune become activated. However, little is known about nature interactions or factors involved local response. In this investigation we studied localization...