Introduction . Bile duct ligation (BDL) and subsequent cholestasis are associated with oxidative stress liver injury fibrosis. Hesperidin (3,5,7‐trihydroxyflavanone 7‐rhamnoglucoside) is a flavanone glycoside abundant in citrus fruits. It has positive effects on diabetic retinopathy, reduced platelet aggregation, blood flow alterations the potential to reduce stress. The aim of this study was evaluate hepatoprotective hesperidin BDL‐induced rats. Methods A total 48 adult male Wistar rats...

Diabetic nephropathy is one of the leading causes end-stage renal disease worldwide. Uncontrolled hyperglycemia and subsequent production glycation end-products activate paths which lead to diabetic nephropathy. The aim this study was assess effects L-lysine on antioxidant capacity, biochemical factors, kidney function, HSP70 level, expression TGFβ, VEGF, RAGE genes in rats with streptozocin-induced diabetes mellitus.Thirty-two male Wistar were randomly allocated four eight-rat groups,...

Background: The high incidence of Non-Alcoholic Fatty Liver Disease (NAFLD) as a hepatic component metabolic syndrome is attributed to the ongoing rise in obesity rates. Given beneficial effects hydroxychloroquine (HCQ) on metabolism, there growing interest combining it with fisetin (FSN), natural product, treat NAFLD more effectively. Objective: efficacy and safety combined therapy FSN HCQ animal models were assessed, focusing liver function, insulin sensitivity, oxidative stress,...

The antihyperglycemic and antioxidant effects of water extract local Viscum album in alloxanized-rats were investigated. This study performed during 2009 Babol University medical sciences (Mazandaran Province, Iran). V. leaves growing on oaks collected extracted with hot water. 90 animals that used this investigation male Wistar rats. 60 rats gavaged 500 1000 mg/kg/day extract. One hour after final feeding, freshly prepared alloxan injected subcutaneously. Then blood glucose level was...

This study is aimed at evaluating the effects of Securigera securidaca (SS) seed extract on cholestatic liver injury induced by bile duct ligation (BDL) in rats. Total polyphenols and flavonoids SS were determined using a colorimetric assay, their components quantified HPLC. Rats four groups underwent BDL common treated for 21 days with either oral distilled water as vehicle, vitamin C, 100 mg/kg extract, or 200 extract. fifth group abdominal incision without water, rats sixth healthy...

In the present study, anti-hyperglycemic and antioxidant potential of Securigerasecuridaca (L.) seed suspension in alloxan-induced hyperglycemic rats was investigated. The male Wistar (180 to 220 g) were divided three groups treated orally for 4 days as follow: group I, control, fed 10 ml/kg/day distilled water, II III gavaged 2 g/kg/day of S. securidaca (L.) seed suspension, respectively. One hour after final feeding, alloxan injected subcutaneously (70 mg/kg B.W). At end experimental...

Abstract Introduction Despite half a century of research on vitamin D (Vit. D), its link to substance abuse and dependence has only been discussed in recent decades. Evidence also shows the involvement Vit. evolution dopaminergic neurons nucleus accumbens, an increase expression tyrosine hydroxylase, regulation processes. The novel idea for this work is taken from hypothesis given about effectiveness dopamine signaling pathway. It therefore presumed that can be considered effective...

Cholestatic liver damage is a chronic disease caused by dysfunction of the hepaticbiliary system. Oxidative stress and inflammation are essential factors in pathogenesis cholestasis. Thus, current study was designed to examine effect empagliflozin on bile duct ligation-induced rats.This done male Wistar rats, which were randomly assigned four experimental groups: sham control (SC), ligation (BDL), SC plus (SC+EMPA) (receiving 10 mg EMPA orally for 7 days), BDL mg/kg (BDL+ EMPA). At end...

The glycemic index (GI) is an important parameter of food quality which compares the hyperglycemic effect a tested meal with pure glucose. For most foods in Middle East, has not been defined yet. aim this study to determine GI Iranian rice and evaluate type cooking method on value. To GI, measured portions containing 50 g carbohydrates were eaten by 10 healthy volunteers (5 men 5 women) after overnight fast. Capillary blood samples taken at 0 (fasting), 30, 60, 90 120 min meal. Blood glucose...

Background and Aim: Despite the anti-cancer antimicrobial properties of licorice extract lavender essential oil, some factors, such as low bioavailability biodegradable, limit their therapeutic use. Using nanoparticles is a method to overcome these restrictions. This study aimed investigate anti-proliferative effects nanoemulsion containing oil on cancer cells; we also evaluated its in vitro. Methods & Materials: In this experimental study, nanoemulsions, were developed by spontaneous...

Background: Hydrogen sulfide (H2 S) is the third most crucial gas that produced inside body, and at physiological levels, it increases a wide range of health properties, such as anti-inflammatory antioxidant effects. Objectives: This study aimed evaluating impact H2 S administration on oxidative stress (OS) in heart liver tissues diabetic rats. Methods: Twenty-eight Wistar rats were randomly divided into 4 groups, namely, healthy control group, groups treated with 50 µM/kg 100 S. After 60...