A5006737463- Proteoglycans and glycosaminoglycans research
- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- Protease and Inhibitor Mechanisms
- Glycosylation and Glycoproteins Research
- Silk-based biomaterials and applications
- Nerve injury and regeneration
- MicroRNA in disease regulation
- Skin and Cellular Biology Research
- Antioxidant Activity and Oxidative Stress
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Helminth infection and control
- Parasite Biology and Host Interactions
- Drug-Induced Hepatotoxicity and Protection
- Trace Elements in Health
- Vitamin C and Antioxidants Research
- Steroid Chemistry and Biochemistry
- Cancer-related molecular mechanisms research
- Pharmacogenetics and Drug Metabolism
- Nitric Oxide and Endothelin Effects
- Retinoids in leukemia and cellular processes
- Biochemical effects in animals
- Metabolism and Genetic Disorders
- Drug Transport and Resistance Mechanisms
Tehran University of Medical Sciences
2016-2025
Ardabil University of Medical Sciences
2019
University of Tehran
1994-2014
Ghaem Hospital
2014
Mashhad University of Medical Sciences
2014
Tarbiat Modares University
2011
Iran University of Medical Sciences
2001
The interaction between silver nanoparticle and calf thymus DNA was studied by UV−visible, fluorescence, far UV circular dichroism (CD) spectroscopies at a physiologic temperature of 37 °C. By the analysis UV−visible titration thermal denaturation studies DNA, it found that can form new complex with double-helical increase Tm value DNA. This kind binding may cause slight change conformation fluorescence emission spectra intercalated ethidium bromide (EB) increasing concentration °C...
Objective: The objective of this study was to investigate the possible protective effects pentoxifylline as a phosphodiesterase-5 inhibitor on malathion-induced oxidative damage rat brain mitochondria. Methods: Rats received malathion (200 mg/kg/day) and (PTX, 50 in combination or alone. Alpha-tocopherol (AT, 15 used positive standard. After 1 week treatment, blood, whole tissue, mitochondria were isolated. activity enzymatic scavengers such glutathione peroxidase (GPx), catalase (CAT),...
Resveratrol has been shown to exert anti-inflammatory and anti-oxidant effects in a variety of cell types, however, its role prevention inflammatory responses mediated by palmitate skeletal muscle cells remains unexplored. In the present study, we investigated resveratrol on palmitate-induced inflammation elucidated underlying mechanisms cells. The results showed that significantly enhanced TNF-α IL-6 mRNA expression protein secretion from C2C12 at 12, 24, 36 h treatments. Increased...
Bladder cancer (BC) is the sixth most common malignancy in men and 17th women. Exosomal long non-coding RNAs (lncRNAs) have been defined as a novel biomarker for BC. The aim of this study to evaluate clinical significance urine exosomal PVT-1, ANRIL PCAT-1 BC patients with tumors classified T1 or T2. Exosomes were isolated from healthy donors, then characterized according their shape, size, exosome markers by Electron Microscopy, Dynamic light scattering, Western blotting. lncRNAs extraction...
Visfatin, which is secreted as an adipokine and cytokine, has been implicated in cancer development progression. In this study, we investigated the NAD-producing ability of visfatin its relationship with SIRT1 (silent information regulator 2) p53 to clarify role breast cancer. MCF-7 cells were cultured treated visfatin. activity was assessed by measuring fluorescence intensity from fluoro-substrate peptide. To investigate effect on acetylation, SDS-PAGE followed western blotting performed...
The purpose of this study was to utilize the Context, Input, Process and Product (CIPP) evaluation model as a comprehensive framework guide initiating, planning, implementing evaluating revised undergraduate medical education programme. eight-year longitudinal consisted four phases compatible with components CIPP model. In first phase, we explored strengths weaknesses traditional programme well contextual needs, assets, resources. For second proposed for considering features. During process...
Cholesterol oxidase is a bifunctional bacterial flavoenzyme which catalyzes oxidation and isomerization of cholesterol. This valuable enzyme has attracted great deal attention because its wide application in the clinical laboratory, synthesis steroid derived drugs, food industries, potentially insecticidal activity. Therefore, development an efficient protocol for overproduction cholesterol could be beneficial this regard. The present study examined role various parameters (host strain,...
Chronic liver disease (CLD) affects millions of people and its impact on bone loss has become a subject interest. Nitric oxide endogenous opioids are suggested to increase during cholestasis/cirrhosis may resorption by different mechanisms. The receptor activator nuclear factor-κB (RANK)/RANK-ligand (RANKL)/osteoprotegerin (OPG) signaling pathway regulates resorption, but role in metabolic subsequent CLD is unknown. We aimed investigate the involvement nitrergic opioidergic systems relative...