A5060963798- Advanced Polymer Synthesis and Characterization
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- biodegradable polymer synthesis and properties
- Photochromic and Fluorescence Chemistry
- Synthetic Organic Chemistry Methods
- Microplastics and Plastic Pollution
- Click Chemistry and Applications
- Photopolymerization techniques and applications
- Supramolecular Chemistry and Complexes
- Molecular Junctions and Nanostructures
- DNA and Nucleic Acid Chemistry
- MicroRNA in disease regulation
- Lipid Membrane Structure and Behavior
- Biomedical and Engineering Education
- Advanced Photocatalysis Techniques
- Orthopaedic implants and arthroplasty
- Supramolecular Self-Assembly in Materials
- Conferences and Exhibitions Management
- Bone Tissue Engineering Materials
- Advanced Nanomaterials in Catalysis
- Chemical Synthesis and Analysis
Massachusetts Institute of Technology
2024
Carnegie Mellon University
2017-2022
Indian Institute of Science Education and Research, Bhopal
2016
Bhopal Memorial Hospital & Research Centre
2016
Photoinduced atom transfer radical polymerization (photo-ATRP) has risen to the forefront of modern polymer chemistry as a powerful tool giving access well-defined materials with complex architecture. However, most photo-ATRP systems can only generate radicals under biocidal UV light and are oxygen-sensitive, hindering their practical use in synthesis biohybrids. Herein, inspired by photoinduced electron transfer-reversible addition-fragmentation chain (PET-RAFT) polymerization, we...
A new procedure for ultrasonication-induced atom transfer radical polymerization (sono-ATRP) in aqueous media was developed. Polymerizations of oligo(ethylene oxide) methyl ether methacrylate (OEOMA) and 2-hydroxyethyl acrylate (HEA) water were successfully carried out the presence ppm amounts CuBr2 catalyst tris(2-pyridylmethyl)amine ligand when exposed to ultrasonication (40 kHz, 110 W) at room temperature. Aqueous sono-ATRP enabled water-soluble monomers with excellent control over...
Abstract A DNA synthesizer was successfully employed for preparation of well‐defined polymers by atom transfer radical polymerization (ATRP), in a technique termed AutoATRP. This method provides homopolymers, diblock copolymers, and biohybrids under automated photomediated ATRP conditions. PhotoATRP selected over other methods because mild reaction conditions, ambient temperature, tolerance to oxygen, no need introduce reducing agents or initiators. Both acrylate methacrylate monomers were...
Atom transfer radical polymerization (ATRP) can be carried out in a flask completely open to air using biocatalytic system composed of glucose oxidase (GOx) and horseradish peroxidase (HRP) with an active copper catalyst complex. Nanomolar concentrations the enzymes ppm amounts Cu provided excellent control over oligo(ethylene oxide) methyl ether methacrylate (OEOMA500 ), generating polymers high molecular weight (Mn >70 000) low dispersities (1.13≤Đ≤1.27) less than hour. The continuous...
Exosomes show potential as ideal vehicles for drug delivery because of their natural role in transferring biological cargo between cells. However, current methods to engineer exosomes without negatively impacting function remain challenging. Manipulating exosome-secreting cells is complex and time-consuming, while direct functionalization exosome surface proteins suffers from low specificity efficiency. We demonstrate a rapid, versatile, scalable method with oligonucleotide tethers enable...
Exosomes are emerging as ideal drug delivery vehicles due to their biological origin and ability transfer cargo between cells. However, rapid clearance of exogenous exosomes from the circulation well aggregation shedding surface proteins during storage limit clinical translation. Here, we demonstrate highly controlled reversible functionalization exosome surfaces with well-defined polymers that modulate exosome’s physiochemical pharmacokinetic properties. Using cholesterol-modified DNA...
An aqueous electrochemically mediated atom transfer radical polymerization (eATRP) was performed in a small volume solution (75 μL) deposited on screen-printed electrode (SPE). The reaction open to air, thanks the use of glucose oxidase (GOx) as an oxygen scavenger. Well-defined poly(2-(methylsulfinyl)ethyl acrylate) (PMSEA), poly(oligo(ethylene oxide) methyl ether methacrylate) (POEOMA), and corresponding DNA–polymer biohybrids were synthesized by small-volume eATRP at room temperature....
A rapid blue-light-induced atom transfer radical polymerization (ATRP) was conducted in a biologically friendly environment. Well-controlled of oligo(ethylene oxide) methyl ether methacrylate (OEOMA) successfully performed aqueous media (1X PBS) under irradiation by blue LED strips. With 10.0 mW/cm2 intensity output at 450 nm, >90% conversion achieved 2 h the presence system comprising glucose, glucose oxidase, and sodium pyruvate. Poly-(OEOMA) synthesized with predetermined Mn low...
Exosomes are 30–200 nm sized extracellular vesicles that increasingly recognized as potential drug delivery vehicles. However, exogenous exosomes rapidly cleared from the blood upon intravenous delivery, which limits their therapeutic potential. Here, we report bioactive exosome-tethered poly(ethylene oxide)-based hydrogels for localized of exosomes. Using cholesterol-modified DNA tethers, lipid membrane was functionalized with initiators to graft polymers in presence additional and...
Iodine-mediated photoATRP was conducted in aqueous media enabling fast and well-controlled polymerizations under visible light without deoxygenation.
Abstract A DNA synthesizer was successfully employed for preparation of well‐defined polymers by atom transfer radical polymerization (ATRP), in a technique termed AutoATRP. This method provides homopolymers, diblock copolymers, and biohybrids under automated photomediated ATRP conditions. PhotoATRP selected over other methods because mild reaction conditions, ambient temperature, tolerance to oxygen, no need introduce reducing agents or initiators. Both acrylate methacrylate monomers were...
Small drug molecules and other important metabolites are delivered <italic>via</italic> a suitable carrier protein-mediated transport through specific receptor.
Lipid nanoparticles (LNPs) have great potential to enable inhaled delivery of mRNA treat pulmonary diseases. However, this has been limited by the challenge nebulizing LNPs. Nebulization LNPs can cause aggregate and release encapsulated mRNA, limiting their efficacy. To overcome challenge, are developed whereby PEG-lipid is fully replaced with a zwitterionic polymer (ZIP)-lipid conjugate greatly enhance nebulizer stability. formulated ZIP-lipids (ZIP-LNPs) were stable nebulization across...
Immune reactions to medical implants often lead encapsulation by fibrotic tissue and impaired device function. This process is thought initiate protein adsorption, which enables immune cells attach mount an inflammatory response. Previously, several antifibrotic materials have been either designed reduce adsorption or discovered via high-throughput screens (HTS) favorably regulate inflammation. The present work introduces antifouling immunomodulatory (AIM) copolymer coatings, combine both...
Abstract Atom transfer radical polymerization (ATRP) can be carried out in a flask completely open to air using biocatalytic system composed of glucose oxidase (GOx) and horseradish peroxidase (HRP) with an active copper catalyst complex. Nanomolar concentrations the enzymes ppm amounts Cu provided excellent control over oligo(ethylene oxide) methyl ether methacrylate (OEOMA 500 ), generating polymers high molecular weight ( M n >70 000) low dispersities (1.13≤ Đ ≤1.27) less than hour....
Sodium pyruvate, a natural intermediate produced during cellular metabolism, is commonly used in buffer solutions and media for biochemical applications. Here we show the use of sodium pyruvate (SP) as reducing agent biocompatible aqueous photoinduced azide-alkyne cycloaddition (CuAAC) reaction. This copper(I)-catalyzed 1,3-dipolar triggered by SP under UV light irradiation, exhibits oxygen tolerance temporal control, provides convenient alternative to current CuAAC systems, particularly...