Andrzej Kułach

ORCID: 0000-0002-3140-1806
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About
Contact & Profiles
Research Areas
  • Cardiac Imaging and Diagnostics
  • Cardiac Arrhythmias and Treatments
  • Acute Myocardial Infarction Research
  • Cardiac Health and Mental Health
  • Cardiac Valve Diseases and Treatments
  • Atherosclerosis and Cardiovascular Diseases
  • Atrial Fibrillation Management and Outcomes
  • Lipoproteins and Cardiovascular Health
  • Biomarkers in Disease Mechanisms
  • Cardiac pacing and defibrillation studies
  • Cardiac Fibrosis and Remodeling
  • Blood Pressure and Hypertension Studies
  • TGF-β signaling in diseases
  • Health Systems, Economic Evaluations, Quality of Life
  • Cardiovascular Function and Risk Factors
  • Adipokines, Inflammation, and Metabolic Diseases
  • Cytokine Signaling Pathways and Interactions
  • Signaling Pathways in Disease
  • Cardiac electrophysiology and arrhythmias
  • Infective Endocarditis Diagnosis and Management
  • Pulmonary Hypertension Research and Treatments
  • Chronic Disease Management Strategies
  • Cardiac Structural Anomalies and Repair
  • Peptidase Inhibition and Analysis
  • Adenosine and Purinergic Signaling

Medical University of Silesia
2008-2025

Foundation of Cardiac Surgery Development
2023

Górnośląskie Centrum Medyczne
2012-2022

University of Silesia in Katowice
2022

Silesian Center for Heart Disease
2022

Background: Heart failure (HF) is a progressive condition associated with reduced life expectancy and quality of life. Atrial fibrillation (AF), the most common arrhythmia in HF patients, significantly worsens symptoms outcomes. The coexistence AF linked to higher morbidity mortality rates, bidirectional relationship exacerbating both conditions. recent evidence has suggested that combining pulmonary vein isolation (PVI) renal denervation (RDN) may offer promising strategy for reducing...

10.3390/jcm14051727 article EN Journal of Clinical Medicine 2025-03-04

Background/Objectives: COVID-19 is associated with various arrhythmias that continue into a post-COVID period and become concern for patients healthcare long time after the infection. This study aimed to assess incidence of their relationship presented symptoms in no history rhythm disturbances who underwent severe within past 6 months. Methods: A total 54 survivors known arrhythmia were enrolled 3–6 months discharge. All subjects echocardiography, 24 h Holter monitoring, received handheld...

10.3390/jcm14082649 article EN Journal of Clinical Medicine 2025-04-12

Advances in the acute treatment of myocardial infarction (AMI) substantially reduced in-hospital mortality, but post-discharge prognosis is still unacceptable. The Managed Care Acute Myocardial Infarction (MC-AMI) a program Poland's National Health Fund that aims at comprehensive post-AMI care to improve long-term prognosis. aim study was assess effect MC-AMI on all-cause mortality one-year follow-up.MC-AMI includes MI treatment, complex revascularization, cardiac rehabilitation (CR),...

10.3390/jcm9103178 article EN Journal of Clinical Medicine 2020-09-30

Background: Managed Care in Acute Myocardial Infarction (MC-AMI) is a program introduced Poland aimed at comprehensive, scheduled, and supervised care for AMI patients to improve longterm prognosis. Aims: Our study compare 24-month mortality the incidence of major cardiovascular events (MACE: composite death, recurrent MI, hospitalization heart failure) cohort treated MC-AMI era (intention-to-treat analysis) vs. similar population before era. Methods: We analyzed 2323 consecutive with AMI:...

10.33963/kp.a2022.0260 article EN Kardiologia Polska 2023-02-28

Despite progress in medical and interventional treatment of acute myocardial infarction (AMI) resulting low in-hospital mortality, the post-discharge prognosis MI survivors is still unacceptable. The Managed Care Acute Myocardial Infarction (MC-AMI, KOS-zawał) a program introduced by Poland's National Health Fund aiming at comprehensive care for patients with AMI to improve prognosis. It includes intervention, complex revascularization, cardiac rehabilitation (CR), scheduled outpatient...

10.5114/aoms.2019.85649 article EN cc-by-nc-sa Archives of Medical Science 2019-06-28

Summary. The prevalence of coronary artery disease (CAD) and acute syndromes in patients with haemophilia is much lower than general population there a lack information regarding safe interventional or surgical treatment CAD haemophiliacs. This report presents case patient moderate A unstable angina pectoris, who underwent successful angioplasty. was pretreated factor VIII (before after the procedure) incision site sealed vessel closure device. Additionally, article discusses issue safety...

10.1111/j.1365-2516.2007.01436.x article EN Haemophilia 2007-04-25

According to recent studies, silent atrial fibrillation (AF) is a common cause of cryptogenic ischemic stroke (CIS). 12-lead electrocardiogram (ECG) and 24 h Holter are not efficient reveal an occult arrhythmic stroke.The aim the study was evaluate 72 Holter, 7 day monitoring, intermittent single-lead ECG recording in patients with CIS identify cases whom free from arrhythmia.72 (aged 60 ± 9 years, 44 males) no findings were enrolled. All had monitoring received handheld recorder (CheckMe,...

10.1515/med-2020-0203 article EN cc-by Open Medicine 2020-01-01

Because atherosclerosis has been proven to be an inflammatory disease, it became obvious that the proper treatment of dyslipidemic patients should not only correct lipid parameters but also inhibit state. One crucial proinflammatory and procoagulant cytokines participating in pathogenesis is interleukin-1beta (IL-1beta). Therefore, aim study was asses effect statin fibrate therapy (for dyslipidemia IIa IIb, respectively) on IL-1beta gene expression monocyte release evaluated each patient....

10.1097/01.fjc.0000151895.80508.c9 article EN Journal of Cardiovascular Pharmacology 2005-01-14

Abstract Background: Inflammation plays a critical role in all stages of atherogenesis, including plaque destabilization leading to the rupture and local thrombosis, clinically manifested as unstable angina (UA) or myocardial infarction (MI). Recent data report enhanced expression numerous pro‐inflammatory genes patients with acute coronary syndrome (ACS) both inflammatory cells. Kinins are peptides involved vasodilation, vascular permeability, pain inflammation. Their effects mediated by...

10.1111/j.1445-5994.2008.01718.x article EN Internal Medicine Journal 2008-12-01

Wstęp: Rak jelita grubego (CRC) jest jednym z najczęściej występujących nowotworów na świecie. W Polsce znajduje się trzeciej pozycji wśród mężczyzn oraz drugiej kobiet pod względem zachorowań nowotwory. Rola chemioterapii w leczeniu CRC zależy od stopnia zaawansowania nowotworu. Chemioterapię uzupełniającą stosuje zawsze III stopniu zaawansowania, a także II stadium klinicznego przy obecności czynników ryzyka. Cel: Celem niniejszej pracy była ocena występowania wczesnych powikłań sercowych...

10.5603/kp.a2016.0163 article PL Kardiologia Polska 2016-11-23

Out-of-hospital cardiac arrest (OHCA) remains a leading cause of global mortality, while survivors are burdened with long-term neurological and cardiovascular complications. OHCA management at the hospital level challenging, due to heterogeneity presentation, critical status patients reaching return spontaneous circulation (ROSC), demands post ROSC treatment. The validity optimal timing for coronary angiography is one important, yet not fully defined, component management. Guidelines state...

10.5603/cj.a2023.0032 article EN cc-by-nc-nd Cardiology Journal 2023-05-12

Cardiac syndrome X (CSX) is defined by typical chest pain, ST segment depression on ECG and normal coronary angiography. Pathology of CSX may involve microvascular dysfunction related to inflammation abnormal pain sensitivity. Kinins are labile peptides participating in vasodilation, pain. Their effects mediated two receptors: B1 B2. The aim the study was assess gene expression kinin receptors peripheral blood mononuclear cells (PBMC) from patients with CSX.The carried out 34 cardiac X, 13...

10.1080/14017430701499379 article EN Scandinavian Cardiovascular Journal 2007-01-01

Cardiac syndrome X (CSX) is characterized by anginal pain with ECG suggestive of ischaemia and normal coronary arteries at angiography. Pathology CSX involves microvascular dysfunction possibly linked metabolic syndrome. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) an enzyme involved in glycolysis. The GAPDH gene a "housekeeping" used for normalization quantitative expression assays. aim the study was to evaluate CSX.The performed 35 patients 10 control subjects. mRNA extracted from...

10.5114/aoms.2010.17085 article EN cc-by-nc-sa Archives of Medical Science 2010-01-01

Introduction: Silent atrial fibrillation (AF) is a common cause of cryptogenic ischemic stroke (CIS). The 24-h-Holter insufficient to reveal an occult arrhythmic and the strategy select patients for long-term monitoring missing. Objectives: aim study was evaluate 7-day-Holter identify cases with in CIS whom free from arrhythmia, assess relation between supraventricular (SV) runs baseline Holter incidence AF 3-year follow-up period. Methods: 78 (aged 60 ± 9 years, 45 males) no findings were...

10.3390/jcdd8070081 article EN cc-by Journal of Cardiovascular Development and Disease 2021-07-19

Cardiac resynchronization therapy (CRT) has been shown to improve outcomes in patients with systolic heart failure (HFREF). However, the relatively high non-responder rate results a need for more precise qualification CRT. The ViaCRT study was designed determine role of contractile reserve and dyssynchrony parameters predicting CRT response. purpose this analysis effect baseline septal flash (CR) on clinical echocardiographic response 12-month follow-up.One hundred thirty-three...

10.5114/aoms.2016.59260 article EN cc-by-nc-sa Archives of Medical Science 2016-01-01
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