A murine monoclonal antibody was identified by its ability to induce a reversible antiproliferative effect on human lymphoma cell line. Immunoprecipitation studies revealed that the reacted with 26-kilodalton surface protein (TAPA-1). diverse group of lines, including hematolymphoid, neuroectodermal, and mesenchymal cells, expressed TAPA-1 protein. Many lymphoid in particular those derived from large lymphomas, were susceptible effects antibody. may therefore play an important role...

The roles of active oxygen, lipid peroxidation, and the antioxidative defence mechanism in gastric mucosal injury induced by treatment with indomethacin rats were investigated. total area erosions concentration peroxides mucosa increased time after administration (20 mg/kg, orally). alpha-tocopherol:total cholesterol ratio serum was significantly decreased activity glutathione peroxidase, an important enzyme to scavenger peroxides, inhibited indomethacin. Treatments superoxide dismutase...

Potent inositol 1,4,6-trisphosphate (IPS) receptor agonists, adenophostin A and B, were found from fungal products.In spite of the striking structural difference IPS, adenophostins to inhibit [sHIIP~ binding more potently than IPS: Ki values for B both calculated be 0.18 PM, while that IPS was 15 11~.Adenophostins induced Ca2+ release cerebellar microsomes intracellular Caz+ stores in permeabilized NG108-16 cells.Adenophostins at concentration as low 1 PM produced a significant microsomes,...

Between March 1976 and December 1992, 137 (57 per cent) of 239 patients with pancreatic duct cell cancer underwent resection; 79 (58 the had combined resection pancreas portal vein. Sixty-three vein alone; six died (mortality rate 10 cent). The mortality was same as that in 58 no In remaining 16 adjacent arteries were also resected, seven deaths. Of alone who curative resection, four survived more than 5 years, accounting for nearly half nine 5-year survivors. Combined is associated both an...

TAPA-1 (the target of an antiproliferative antibody) is a 26-kDa cell surface protein expressed on most human lines. member evolutionarily related family proteins all which contain four transmembrane domains. A model proposed for topology based proteolysis studies in the vitro translated embedded into microsomal membranes. This analysis predicts that amino and carboxyl termini molecule are cytoplasmic two hydrophilic regions extracellular. The antigenic epitope contained within subregion...

The influence of reactive oxygen species (ROS) on the surface modification titanium implants and osseointegration is unclear. aim this study was to evaluate ability dioxide (TiO 2 ) generate ROS in presence H O determine whether any thus generated play a role osseointegration, as measured by electron spin resonance (ESR) spin-trapping with 5,5-dimethyl-1-pyrolline- N-oxide (DMPO). We demonstrate that TiO together hydroxyl radicals (HO • ), shown time-dependent increase concentration ESR...

S. Takahashi, T. Shibano and N. Hagihara, J. Chem. Soc. D, 1969, 161 DOI: 10.1039/C29690000161

<b>Background:</b> The pterygium is a growth onto the cornea of fibrovascular tissue that continuous with conjunctiva, whereas mechanisms cell proliferation in epithelium are unknown. <b>Aim:</b> To analyse histopathology and expression cycle-related molecules tissues. <b>Methods:</b> Seven pterygia were surgically removed using bare-sclera procedure, three normal bulbar conjunctivas also obtained. Formalin-fixed, paraffin-wax-embedded tissues analysed by immunohistochemistry anti-p27(KIP1),...

A serodiagnostic assay system to detect human anisakiasis is described. This uses a microenzyme-linked immunosorbent with monoclonal antibody An2 that recognizes the antigen specifically found in Anisakis simplex larvae. The data showed sera from infected patients reacted strongly A. larvae was immobilized on microplates. Patients' IgG, IgA, IgM, and IgE An2-defined at 4 or 5 weeks 1 7 days, respectively, after onset of clinical symptoms anisakiasis. However, healthy persons did not react,...

Synthese par reaction de iodoarenes avec des cyanoacetates d'alkyle en presence dichloro bis [triphenylphosphine] palladium dans le monoglyme

The nephrotoxic effects of vancomycin hydrochloride (VCM) and the potential drug-drug interaction with cilastatin sodium (CS) were examined in rabbits. aim study was to measure possible dose-related suppressive or elimination by adverse reactions generated kidneys To clarify interactions these two drugs, we nephrotoxicity pharmacokinetics VCM rabbit when administered alone coadministered CS. (300 mg/kg body weight as an intravenous bolus; n = 5) caused typical symptoms nephrotoxicity, such...

Journal Article Smad7-deficient mice show growth retardation with reduced viability Get access Masayoshi Tojo, Tojo 1Department of Molecular Pathology, Graduate School Medicine, University Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033; 2Department Biology, Life and Environmental Sciences; 3Department Anatomy Embryology, Biomolecular Integrated Medical Sciences, Comprehensive Human Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575; 4Laboratory Protein Metabolism, Metropolitan Institute Science, 2-1-6...

Abstract Tumor-infiltrating lymphocytes (TIL) have been described in a variety of human solid tumors. It is unknown whether such T cells are nonspecific inflammatory or subset specific host immune responses. To examine this question, we analyzed the clonotypes TCR beta-chain messages expressed TIL, draining lymph nodes, and PBL 10 patients with uterine ovarian We report here that TIL bears distinct cell clonotype accumulations only without obvious metastasis. In contrast, clonally expanded...

Ischemia and reperfusion are of the greatest importance in pathology many diseases. We investigated roles oxygen-derived free radicals lipid peroxidation gastric mucosal injury, such as spotty linear hemorrhagic erosions, induced rats by ischemia-reperfusion. The injury increase thiobarbituric acid (TBA) reactants mucosa ischemia-reperfusion were significantly inhibited treatment with SOD catalase. These results suggest that play important pathogenesis acute lesions

Relationships between the onset of pustulosis palmaris et plantaris, periodontitis and heat shock proteins were studied by using enzyme-linked immunosorbent assay to examine levels immunoglobulin G (IgG) against Escherichia coli GroEL, a recombinant DnaJ Actinobacillus actinomycetemcomitans protein, synthetic peptide made from 180th 188th amino acids Mycobacterium bovis BCG Hsp65, human Hsp60, in sera obtained 43 plantaris patients judged have chronic infectious diseases oral cavity. We...

Effects of synthetic phenolic antioxidants l-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), butylated hydroxyanisole (BHA), hydroxytoluene (BHT), tert-butylhydroquinone (TBHQ) and propyl gallate (PG) on 2-amino-3,8-dimethylimidazo[4,5-F]quinoxaline (MelQx)- or activated MelQx-induced mutagenesis rat hepatocarcinogenesis were compared, the association between antioxidative activity inhibition carcinogenesis was examined. When antimutagenic five against MelQx- compared in Ames assay using...

<h3>Aim:</h3> The pterygium represents an invasion of a wing altered ocular surface tissue into the normal cornea. head itself is slightly elevated and white, which only site firm adhesion to globe. mechanisms cell proliferation in epithelium, however, are unknown. aim this study was analyse expression molecules tissues. <h3>Methods:</h3> Six pterygia were surgically removed using bare-sclera procedure, two corneas bulbar conjunctiva also obtained. Formalin-fixed, paraffin-embedded tissues...