A5088420422- Liver physiology and pathology
- Sarcoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Biochemical and Molecular Research
- Genetic factors in colorectal cancer
- Wnt/β-catenin signaling in development and cancer
- Hereditary Neurological Disorders
- Bone Metabolism and Diseases
- Uterine Myomas and Treatments
- Eosinophilic Esophagitis
- Orthopaedic implants and arthroplasty
- Occupational and environmental lung diseases
- Medicinal Plant Research
- Pericarditis and Cardiac Tamponade
- Bone health and treatments
- Protein Kinase Regulation and GTPase Signaling
- Pharmacological Effects and Toxicity Studies
- Pleural and Pulmonary Diseases
- Lipid metabolism and disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tuberous Sclerosis Complex Research
- Oral Health Pathology and Treatment
- Poisoning and overdose treatments
Western University
2022-2023
Massachusetts General Hospital
2017
Harvard University
2017
Alberta Health Services
2017
Brigham and Women's Hospital
2017
Calgary Laboratory Services
2011-2015
University of Calgary
2011-2015
Foothills Medical Centre
2014
Cereal Disease Laboratory
2013
University of Pittsburgh
2011
Transient Receptor Potential Melastatin–8 (TRPM8), a recently identified member of the transient receptor potential (TRP) family ion channels, is activated by mild cooling and chemical compounds such as supercooling agent, icilin. Since cooling, possibly involving TRPM8 stimulation, diminishes injury-induced peripheral inflammation, we hypothesized that activation may also attenuate systemic inflammation. We thus studied involvement in regulating colonic inflammation using two mouse models...
BACKGROUND The noninvasive follicular variant of papillary thyroid carcinoma (PTC) has an indolent clinical behavior in comparison with other PTCs, including the invasive (IFVPTC). Recently, term neoplasm papillary‐like nuclear features (NIFTP) was introduced to emphasize low biological potential these tumors. This study compares clinical, cytological, and molecular NIFTP IFVPTC. METHODS consisted 97 fine‐needle aspiration biopsy (FNAB) cases corresponding surgical pathology from archives...
ADAM8 expression is increased in the interface tissue around a loosened hip prosthesis and pannus synovium of patients with rheumatoid arthritis, but its potential role these processes unclear. stimulates osteoclast (OCL) formation, effects overexpression or loss vivo mechanisms responsible for on osteoclastogenesis are unknown. Therefore, to determine modulating ADAM expression, we generated tartrate-resistant acid phosphatase (TRAP)-ADAM8 transgenic mice that overexpress OCL lineage...
Low and high-grade endometrial stromal sarcomas (ESS) can be distinguished on a morphologic basis. Low-grade ESS is composed of oval cells that resemble normal proliferative-phase stroma, while the well-known round growing in nests separated by delicate sinusoidal vasculature. Recurrent JAZF1 rearrangements have been reported to most frequent low-grade (up 60%), YWHAE are characteristic ESS. Herein, we report case 45-yr-old woman with stage IA typical who developed multiple abdominopelvic...
Hepatic stellate cells (HSCs) are extracellular matrix-producing that play a pivotal role in liver fibrogenesis. During injury and when placed vitro, HSCs undergo phenotypic transition from quiescent retinoid-storing to activated retinoid-deficient myofibroblast-like cells. Although several mediators including reactive oxygen species, platelet derived growth factor, transforming factor-beta (TGF-β) tumour necrosis factor-alpha (TNF-α) were implicated HSC activation, the cellular signalling...
Primary pericardial malignant mesothelioma (PMPM) is extremely rare with an incidence less than 0.0022%. It comprises 0.7% of all cases. To date, approximately 350 cases have been reported in the literature. Its typical presentation insidious, nonspecific signs and symptoms, usually results constrictive pericarditis, cardiac tamponade congestive heart failure either by a serous effusion or direct tumorous constriction heart. With exception several case reports, outcome uniformly fatal,...
Esophageal lichen planus (LP) has been described as a cause of nonspecific esophagitis that may dysphagia, but its incidence is unknown. We aimed to estimate the esophageal LP in defined geographic region and describe clinical characteristics affected patients.A histopathology database for population 1 million people was searched all mucosal biopsy results over an 8-year period. Cases showing inflammation or abnormalities without diagnosis after three more biopsies were reviewed findings...
Complete deficiency of apolipoprotein (apo) B-containing lipoproteins can result from both abetalipoproteinemia (ABL) and homozygous hypobetalipoproteinemia (HoHBL), caused by bi-allelic loss-of-function variants in the MTTP APOB genes encoding microsomal triglyceride transfer protein B, respectively. Both conditions are associated with failure to assemble secrete apo intestine liver, resulting absence chylomicrons, very low-density remnants, lipoproteins. Because absorption transport fat...