A5061174646- Advanced Biosensing Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Antibiotic Resistance in Bacteria
- Antimicrobial Peptides and Activities
- SARS-CoV-2 detection and testing
- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Bacterial biofilms and quorum sensing
- Antimicrobial agents and applications
- Drug-Induced Hepatotoxicity and Protection
- Tryptophan and brain disorders
- Geophysical and Geoelectrical Methods
- Geochemistry and Elemental Analysis
- Vector-borne infectious diseases
- Microbial infections and disease research
- Polymer Surface Interaction Studies
- Biochemical and Structural Characterization
- Liver Disease Diagnosis and Treatment
- Mobile Health and mHealth Applications
- Enzyme Catalysis and Immobilization
- Geomagnetism and Paleomagnetism Studies
- SARS-CoV-2 and COVID-19 Research
- Single-cell and spatial transcriptomics
Furtwangen University
2020-2024
University of Tübingen
2020-2023
Karlsruhe Institute of Technology
2017-2019
Abstract Magnetotactic bacteria are microscale complex natural systems that synthesize magnetic nanoparticles through biologically controlled mineralization. Nanoparticles produced by this process biocompatible due to the presence of surrounding membranes. The mechanism controlling synthesis is cost-effective and executed genomes (operons). results monodispersed displaying advantages over polydispersed ones synthesized physical chemical methods. In work, we isolated Pseudomonas aeruginosa...
Abstract Lyme disease is the most common tick‐borne infectious in Europe and North America. Previous studies discovered immunogenic role of a surface‐exposed lipoprotein (VlsE) Borreliella burgdorferi . We employed high density peptide arrays to investigate antibody response VlsE protein VlsE‐positive patients by mapping as overlapping peptides subsequent in‐depth epitope substitution analyses. These investigations led identification fingerprints represented number key residues that are...
Point-of-care (POC) diagnostics, in particular lateral flow assays (LFA), represent a great opportunity for rapid, precise, low-cost and accessible diagnosis of disease. Especially with the ongoing coronavirus disease 2019 (COVID-19) pandemic, rapid point-of-care tests are becoming everyday tools identification prevention. Using smartphones as biosensors can enhance POC devices portable, platforms healthcare medicine, food environmental monitoring, improving documentation remote,...
Vaccinations are among the most potent tools to fight infectious diseases. However, cross-reactions an ongoing problem and there is urgent need fully understand mechanisms of immune response. For development a methodological workflow, linear epitopes in response tetanus toxin investigated sera 19 vaccinated Europeans applying epitope mapping with peptide arrays. The prominent epitope, appearing nine different (923 IHLVNNESSEVIVHK937 ), substitution analysis identify amino acids that crucial...
OPINION article Front. Pharmacol., 20 November 2020Sec. Experimental Pharmacology and Drug Discovery Volume 11 - 2020 | https://doi.org/10.3389/fphar.2020.584881
Abstract Microarrays are an important tool in modern research that allow the rapid screening of many different interactions simultaneously. Peptide arrays, which bear peptides arranged separate spots, permit high‐throughput to investigate linear and cyclic binding sites. To study conformational or discontinuous sites, protein arrays major choice. However, tremendous costs for generation high‐density high purity restrict progress research. Therefore, peptide‐based can mimic assembled peptide...
Improving medical implants with functional polymer coatings is an effective way to further improve the level of care. Antibacterial and biofilm-preventing properties are particularly desirable in area wound healing, since there a generally high risk infection, often chronic course case biofilm formation. To prevent this we here report polymeric design polymer-bound N-acetyl-glucosamine-oligoethylene glycol residues that mimic cationic, antibacterial, biocompatible chitosan surface. The...
Recent research has concentrated on the development of suitable in vitro cell models for early identification hepatotoxicity during drug order to reduce number animal and obtain a better predictability hepatotoxic reactions humans. The aim presented study was identify translational biomarkers acute liver injury human patients that can serve as hepatocellular vivo simple models. Therefore, 188 different metabolites from with acute-on-chronic failure before after transplantation were analyzed...
Peptide microarrays are a fast-developing field enabling the mapping of linear epitopes in immune response to vaccinations or diseases and high throughput studying protein-protein interactions. In this respect, rapid label-free measurement protein layer topographies array format is great interest but also challenge due extremely low aspect ratios peptide spots. We have demonstrated potential vertical scanning interferometry (VSI) for detailed morphological analysis arrays binding antibodies....
Immobilization of antibiotics to surfaces via PDMA by UV-crosslinking providing a highly efficient diagnostic β-lactamase assay. The method is transferable different substrate materials and devices as well chemical substances.
PDMA surface functionalization via UV-crosslinking leads to increased substrate turnover and initial velocities, allowing more sustainable enzymatic reactions.
Abstract Point-of-care (POC) diagnostics, in particular lateral flow assays (LFA), represent a great opportunity for rapid, precise, low-cost and accessible diagnosis of disease. Especially with the ongoing coronavirus disease 2019 (COVID-19) pandemic, rapid point-of-care tests are becoming everyday tools identification prevention. Using smartphones as biosensors can enhance POC devices portable, platforms healthcare medicine, food environmental monitoring, improving documentation remote,...