A5101891779- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sleep and related disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolomics and Mass Spectrometry Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Sepsis Diagnosis and Treatment
- Circadian rhythm and melatonin
- Sleep and Work-Related Fatigue
- Sleep and Wakefulness Research
- Nitric Oxide and Endothelin Effects
- Cardiovascular Health and Disease Prevention
- Synthesis and biological activity
- Inflammatory Biomarkers in Disease Prognosis
- Immune cells in cancer
- Genomics, phytochemicals, and oxidative stress
- Hormonal and reproductive studies
- Sexual function and dysfunction studies
- High Altitude and Hypoxia
- Gout, Hyperuricemia, Uric Acid
- Neuroscience of respiration and sleep
- Neuropeptides and Animal Physiology
- Synthesis and Reactions of Organic Compounds
- Selenium in Biological Systems
Université Libre de Bruxelles
2012-2023
Hôpital Civil de Charleroi
2011-2021
Grand Charleroi Hospital
2009-2018
UCLouvain
2010
Institut Calot
2010
Centre Hospitalier Universitaire de Tivoli
2007
University of Chieti-Pescara
2006
Abstract Propylene glycol and glycerol are electronic cigarettes vehicles allowing liquid vaporization nicotine transport. The respective effects of these different constituents on the cardiovascular system unknown. We assessed differential (propylene glycerol) microcirculatory function, arterial stiffness, hemodynamic parameters oxidative stress. Twenty-five tobacco smokers were exposed to vaping with without nicotine, sham vaping, in a randomized, single blind, 3-period crossover design...
Because propolis contains many types of antioxidant compounds such as polyphenols and flavonoids, it can be useful in preventing oxidative damages. Ethyl acetate extracts from several Algerian regions show high activity by scavenging free radicals, lipid peroxidation inhibiting myeloperoxidase (MPO). By fractioning assaying ethyl extracts, was observed that both flavonoids contribute to these activities. A correlation between the polyphenol content MPO inhibition. However, seems kaempferol,...
Prostatic diseases are a common health problem among males in Western countries, and include chronic prostatic diseases, which have an unclear pathogenesis few treatment options. In vitro vivo studies describe oxidative stress as major pathway involved the occurrence of benign hyperplasia, cancer prostatitis. Thus, cascade is potential target for diseases. This paper presents systematic review available data concerning association between most describes options that act upon this pathway.
The term angiogenesis refers to sprouting of new blood vessels from pre-existing ones. angiogenic process involves cell migration and tubulogenesis requiring interaction between endothelial cells the extracellular matrix. Human peroxidasin 1 (hsPxd01) is a multidomain heme peroxidase found embedded in basement membranes. As it promotes stabilization matrix, we investigated its possible role both vitro vivo. We analysed effects gene silencing supplementation by recombinant hsPxd01 TeloHAEC on...
Background Uric acid (UA) is a plasmatic antioxidant that has possible effects on blood pressure. The of UA endothelial function are unclear. We hypothesize not impaired unless significant depletion achieved through selective xanthine oxidase inhibition with febuxostat and recombinant uricase (rasburicase). Methods Results Microvascular hyperemia, induced by iontophoresis acetylcholine sodium nitroprusside, heating-induced local hyperemia after saline specific nitric oxide synthase inhibitor...
Objectives Many studies have evaluated the ways in which sleep disturbances may influence inflammation and possible links of this effect to cardiovascular risk. Our objective was investigate effects chronic restriction recovery on several blood biomarkers. Methods Results Nine healthy male non-smokers, aged 22–29 years, were admitted Sleep Laboratory for 11 days nights under continuous electroencephalogram polysomnography. The study consisted three baseline 8 hours (from pm 7 am), five...
Low-density lipoprotein (LDL) oxidation is a key step in atherogenesis, promoting the formation of lipid-laden macrophages. Here, we compared effects copper-oxidized LDLs (OxLDLs) and more physiologically relevant myeloperoxidase-oxidized (MoxLDLs) murine RAW264.7 macrophages human peripheral blood monocyte-derived Both oxidized LDLs, contrary to native induced foam cell an intracellular accumulation reactive oxygen species (ROS). This oxidative stress was responsible for activation...
The aim of this pilot study was to explore the risk metabolic abnormalities in steel workers employed different shift-work rotations. Male a factory [16 fast clockwise rotation (CW), 18 slow counterclockwise (CC), 9 day (DW); mean age 43.3 ± SD 6.8 years] with at least 5 years experience their current work schedule participated. All provided fasting blood samples between 06:00 and 08:00 h for plasma glucose, insulin, apo-lipoproteins A B (ApoA, ApoB), high- low-density lipoproteins (HDL...
The aim of this study was to investigate markers inflammation and oxidative stress in the corpus cavernosum (CC) compare levels inflammatory recorded CC venous blood from arm examine potential impact parameters on erectile function endothelial dysfunction vitro. Ninety-seven patients with no complaint (ED) at inclusion were prospectively included completed Erectile Function domain IIEF questionnaire. Several parameters, including lipids, MPO-dependent oxidised LDL (Mox-LDL), IL-8, IL-18,...
Macrophages and oxidized LDLs play a key role in atherogenesis but their heterogeneity has been neglected up to now. are prone polarization subsets of polarized macrophages have described atheromas. can be not only chemically by copper (Ox-LDLs) also enzymatically myeloperoxidase (MpOx-LDLs) resulting poor lipid peroxides. The effects physiologically relevant myeloperoxidase-oxidized on macrophage or remain largely unknown. In this study, the were investigated monitoring expression M1 M2...
Intermittent hypoxia (hypoxia-reoxygenation) is often associated with cardiovascular morbidity and mortality. We describe a new device which can be used to submit cohorts of mice controlled standardised hypoxia-normoxia cycles at an individual level. Mice were placed in compartments similar gas flow parameters provided using open loop strategy. Evaluations made computational fluid dynamics confirmed by studying changes haemoglobin oxygen saturation vivo. also modified the system demonstrated...
We evaluated the relationship between IL-8 and prostate cancer (PCa) with emphasis on diagnosis, aggressiveness prognosis.Prostate-specific antigen (PSA) serum were collected from patients undergoing biopsy. expression was immunohistochemistry labeling index. Complete follow-up of this cohort achieved over a period up to 6 years continuous PSA levels.Among 135 patients, level did not correlate diagnosis or PCa. In 52 radical prostatectomy specimens, higher index detected in tumor areas (0.4...
Inflammatory processes are common in intensive care (ICU) patients and can induce multiple changes metabolism, leading to increased risks of morbidity mortality. Metabolomics enables these modifications be studied identifies a patient's metabolic profile. The objective is precise if the use metabolomics at ICU admission help prognostication. This prospective ex-vivo study, realized university laboratory medico-surgical ICU. Metabolic profiles were analyzed by proton nuclear magnetic...