A5024940221- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Education Pedagogy and Practices
- Business and Management Studies
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Labor Law and Work Dynamics
- Administrative Law and Governance
- Protein Tyrosine Phosphatases
- Receptor Mechanisms and Signaling
- Legal and Labor Studies
- Advanced Nanomaterials in Catalysis
- Urban and sociocultural dynamics
- Mining Techniques and Economics
- Metal Extraction and Bioleaching
- Neonatal Health and Biochemistry
- Science and Education Research
- Galectins and Cancer Biology
- Methemoglobinemia and Tumor Lysis Syndrome
- Biomedical Research and Pathophysiology
- Gender, Sexuality, and Education
- Brazilian Legal Issues
- Science and Science Education
- Cellular transport and secretion
- Finance, Taxation, and Governance
Instituto Nacional de Estudos e Pesquisa
2023
Instituto Federal do Amazonas
2023
Universidade Federal de São Paulo
2023
Universidade Estadual de Feira de Santana
2023
Universidade Federal de Pelotas
2023
Universidade Federal de Pernambuco
2023
Universidade Federal do Ceará
2020
University of Virginia
2012-2018
Pontificia Universidad Católica de Chile
2009-2010
Millennium Institute for Integrative Biology
2009
Abstract A major obstacle to presymptomatic diagnosis and disease‐modifying therapy for Alzheimer's disease (AD) is inadequate understanding of molecular mechanisms AD pathogenesis. For example, impaired brain insulin signaling an hallmark, but whether how it might contribute the synaptic dysfunction neuron death that underlie memory cognitive impairment has been mysterious. Neuron in often caused by cell cycle reentry (CCR) mediated amyloid‐β oligomers (AβOs) tau, precursors plaques...
Galectins have been implicated in T cell homeostasis playing complementary pro-apoptotic roles. Here we show that galectin-8 (Gal-8) is a potent agent Jurkat cells inducing complex phospholipase D/phosphatidic acid signaling pathway has not reported for any galectin before. Gal-8 increases phosphatidic signaling, which enhances the activity of both ERK1/2 and type 4 phosphodiesterases (PDE4), with subsequent decrease basal protein kinase A activity. Strikingly, rolipram inhibition PDE4...
Endocytosis modulates EGFR function by compartmentalizing and attenuating or enhancing its ligand-induced signaling. Here we show that it can also control the cell surface versus intracellular distribution of empty/inactive EGFR. Our previous observation PKA inhibitors induce internalization prompted us to test phosphatidic acid (PA) generated phospholipase D (PLD) as an endogenous down-regulator activity, which activates rolipram-sensitive type 4 phosphodiesterases (PDE4) degrade cAMP. We...
Kernicterus is an encephalopathy resulting from the cerebral deposition of unconjugated bilirubin in neonatal period. We report a case kernicterus where MRI demonstrated bilateral symmetric high signal intensity and volume loss hippocampus addition to globus pallidus subthalamic nucleus hyperintensity onT2-weighted images. The authors believe that hippocampal sclerosis, plays role adding specificity imaging diagnosis kernicterus.
The mechanisms of mitochondrial dysfunction in Alzheimer’s Disease (AD) are incompletely understood. Using two-photon fluorescence lifetime microscopy NAD(P)H and tracking brain oxygen metabolism with multi-parametric photoacoustic microscopy, we show that activation lysosomal mechanistic target rapamycin complex 1 (mTORC1) by insulin or amino acids stimulates activity regulates DNA synthesis neurons. Amyloid-β oligomers, which precursors amyloid plaques AD stimulate mTORC1 protein kinase at...

 O objetivo deste estudo foi analisar a percepção do usuário Comitê de Ética em Pesquisa (CEP) acerca da submissão Protocolo Pesquisa. Esse é um exploratório-descritivo com abordagem qualitativa realizado no CEP. Os sujeitos foram os estudantes graduação e pós-graduação usuários Utilizamos entrevista semi-estruturada análise discurso sujeito coletivo. Verificou-se que maioria dos desconhece o processo construção folha rosto não realiza leitura Resolução CNS 196 1996. Embora submetam...
mTOR, the protein kinase subunit of mTORC1 and mTORC2 multiprotein complexes, plays a major role in cell proliferation is hyperactivated Alzheimer's disease (AD). Amyloid-β (Aβ) tau respectively accumulate as insoluble plaques tangles AD brain, where ectopic cycle re-entry (CCR) leads to massive neuron death, which along with synaptic dysfunction, causes memory cognitive loss. Neuronal CCR results partly from soluble Aβ oligomers (AβOs) activating fyn, PKA CaMKII, phosphorylate at Y18, S409...
Brain insulin resistance, an Alzheimer’s disease (AD) hallmark that is provoked by amyloid-β oligomers (AβOs) (Bomfim, et al. 2012. J Clin Inv 122: 1339-1353), a potentially fundamental driver of AD symptoms, but the mechanisms which it causes synaptic dysfunction and neuron death underlie memory cognitive impairment had remained unknown. Neuron in often caused ectopic cell cycle re-entry (CCR) mediated AβOs tau, precursors plaques tangles brain. Primary mouse neurons treated with AβOs,...
O curso “Artesanato Têxtil em Macramê” fez parte das ações de extensão desenvolvidas no IFAM – Campus Eirunepé e teve como objetivo qualificar profissionalmente, por meio do ensino da técnica artesanal Macramê, mulheres desempregadas situação vulnerabilidade social, priorizando companheiras ou familiares pessoas privadas liberdade, sob custódia Justiça, município Eirunepé/AM. Macramê é uma manual têxtil que peças decorativas uso pessoal são tecidas com cordões barbantes utilizando somente as...
como desafio o enfrentamento da ciência dogmática,
Mitochondrial dysfunction is associated with Alzheimer's Disease (AD), but the underlying mechanisms remain poorly defined. Here we describe how non-invasive monitoring of mitochondrial activity in live cultured neurons led us to uncover a previously unknown inter-organelle signaling pathway that controls functioning and detailed mechanism by which such disrupted AD. Two-photon fluorescence lifetime (2P-FLIM) imaging NAD(P)H, copper click chemistry were respectively used detect changes human...
Este ensaio tem por objetivo refletir acerca dos pressupostos comportamentais que permeiam a Nova Economia Institucional (NEI) e sua interface com Contabilidade. Para tanto, discute das principais características da NEI (em especial racionalidade limitada o oportunismo), concepção, visão firma contribuição para os estudos em A oportunismo são dois impactam na presença de custos transação. Como é limitada, contratos não perfeitos isso precisam ser revistos controlados. O comportamento...