A5016929642- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- CNS Lymphoma Diagnosis and Treatment
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Lymphoma Diagnosis and Treatment
- Photoreceptor and optogenetics research
- Functional Brain Connectivity Studies
- Phosphodiesterase function and regulation
- Viral-associated cancers and disorders
- Glioma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Autism Spectrum Disorder Research
- Vascular Malformations Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Genetics and Neurodevelopmental Disorders
- Electroconvulsive Therapy Studies
- Epilepsy research and treatment
- Attention Deficit Hyperactivity Disorder
- Vector-borne infectious diseases
- Treatment of Major Depression
University of British Columbia
2021-2023
Queen's University
2021
University of Toronto
2015-2016
Committee on Publication Ethics
2016
Health Sciences Centre
2015
Sunnybrook Health Science Centre
2015
Critically ill patients with severe inflammation often exhibit heightened sensitivity to general anesthetics; however, the underlying mechanisms remain poorly understood. Inflammation increases number of γ-aminobutyric acid type A (GABAA) receptors expressed on surface neurons, which supports hypothesis that up-regulation GABAA receptor activity by anesthetics, thereby enhancing behavioral these drugs.To mimic in vitro, cultured hippocampal and cortical neurons were pretreated interleukin...
Extrasynaptic δ-subunits containing GABA A receptors (δGABA Rs) are sensitive targets for several commonly used hypnotic agents and mediate tonic neuronal inhibition. δGABA Rs highly expressed within the thalamus their activation promotes a switch from to burst firing in vitro . Here we test two hypotheses vivo (1) Activation of thalamic will elicit electrocortical signatures consistent with widespread thalamocortical such as increased delta oscillations (1–4 Hz) reciprocal changes...
A reduction in the activity of GABAA receptors, particularly α5 subunit-containing receptors (α5GABAARs), has been implicated etiology Autism Spectrum Disorders (ASD). Genetically modified mice that lack α5GABAARs (Gabra5-/-) exhibit autism-like behaviors and both enhanced impaired learning memory, depending on behavioral task. The aim this study was to examine electroencephalogram (EEG) sleep-wake Gabra5-/- wild-type mice. In addition, since some individuals with ASD can elevated innate...
Despite the prevalence of working memory deficits in schizophrenia, neuronal mechanisms mediating these are not fully understood. Importantly, spatial identified numerous mouse models that exhibit schizophrenia-like endophenotypes. The hippocampus is one major brain regions actively encodes location, possessing pyramidal neurons, commonly referred to as 'place cells', fire a location-specific manner. This study tests hypothesis mice with endophenotype impaired encoding location hippocampus....
Abstract Background Alterations in thalamic γ-aminobutyric acid–mediated signaling are thought to underlie the increased frontal α-β frequency electrocortical activity that signals anesthetic-induced loss of consciousness with acid receptor type A (GABAAR)–targeting general anesthetics. The anesthetic etomidate elicits phasic extrasynaptic GABAAR activation (“spillover” inhibition) at thalamocortical neurons vitro. We hypothesize this action thalamus is sufficient trigger an increase and...
Background: Neuroborreliosis affects approximately 10-15% of people with untreated Lyme disease and typically declares itself 2-18 weeks after infection. North American neuroborreliosis often manifests cranial nerve palsy, meningitis, and/or radiculoneuritis. Methods: Here we describe a case also highlight some the rare manifestations systemic disease. A 65-year old male presented subacute history progressive upper extremity weakness, neck pain, headache. This occurred in context recent tick...
Alterations in thalamic GABAergic signaling are implicated mediating the rise 12–30 Hz electroencephalogram (EEG) activity that signals anesthetic-induced loss-of-consciousness with GABAA receptor-targeting general anesthetics. A number of modeling studies have identified alterations thalamocortico-corticothalamic same network generates sleep spindles would be sufficient to elicit this key EEG signature anesthetic hypnosis agents. Accordingly, we hypothesize targeted stimulation circuitry...
This is a unique case that describes the presentation, investigations, and disease trajectory of fatal, clonal CD8-positive T-cell lymphoproliferative disorder in an otherwise healthy immunocompetent patient with Epstein-Barr virus seronegative status. Central nervous system involving disorders are rare typically encountered setting immunocompromise. These often associated aggressive cytomorphological features characteristic magnetic resonance imaging patterns, which were not seen this...