A5014674158- Magnesium Alloys: Properties and Applications
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Bone Tissue Engineering Materials
- Magnesium in Health and Disease
- Advanced X-ray and CT Imaging
- Orthopaedic implants and arthroplasty
- Microstructure and mechanical properties
- Hydrogen Storage and Materials
- Aluminum Alloys Composites Properties
- Advanced X-ray Imaging Techniques
- Hydrogen embrittlement and corrosion behaviors in metals
- Bone health and treatments
- Endodontics and Root Canal Treatments
- Magnetic Properties of Alloys
- Magnetic and Electromagnetic Effects
- Seismic Imaging and Inversion Techniques
- Machine Learning in Materials Science
- Advanced Welding Techniques Analysis
- Aluminum Alloy Microstructure Properties
- Laser Applications in Dentistry and Medicine
- Bone health and osteoporosis research
- Connective tissue disorders research
- Metal and Thin Film Mechanics
- Corrosion Behavior and Inhibition
Helmholtz-Zentrum Hereon
2021-2025
Implant removal is unnecessary for biodegradable magnesium (Mg)-based implants and, therefore, the related risk implant-induced fractures limited. Aging, on other hand, associated with low bone-turnover and decreased bone mass density, thus increased fracture risk. Osteoporosis accompanied by Mg deficiency, we hypothesized that Mg-based may support formation Mg2+ ion release in an ovariectomy-induced osteoporotic rat model. Hence, investigated osseointegration implant degradation of a...
Magnesium (Mg) alloys have become a potential material for orthopedic implants due to their unnecessary implant removal, biocompatibility, and mechanical integrity until fracture healing. This study examined the
Magnesium (Mg) - based alloys are becoming attractive materials for medical applications as temporary bone implants support of fracture healing, e.g. a suture anchor. Due to their mechanical properties and biocompatibility, they may replace titanium or stainless-steel implants, commonly used in orthopedic field. Nevertheless, patient safety has be assured by finding long-term balance between metal degradation, osseointegration, ultrastructure adaptation element distribution organs. In order...
Magnesium (Mg)-based implants have become an attractive alternative to conventional permanent in the orthopedic field. While biocompatibility, degradation kinetics, and osseointegration of Mg-based been mostly investigated, impact products on bone remodeling potential systemic effects remains unclear. The aim this study was evaluate early mid-term local tissue responses degrading ultrahigh-purity ZX00 (Mg-Zn-Ca alloy) Mg (XHP-Mg) pins a juvenile healthy rat model. differences between implant...
Magnesium (Mg)-based implants are highly attractive for the orthopedic field and may replace titanium (Ti) as support fracture healing. To determine implant-bone interaction in different bony regions, we implanted Mg-based alloy ZX00 (Mg < 0.5 Zn Ca, wt%) Ti-screws into distal epiphysis metaphysis of sheep tibiae. The implant degradation osseointegration were assessed vivo ex after 4, 6 12 weeks, using a combination clinical computed tomography, medium-resolution micro tomography (µCT)...
An increasing prevalence of bone-related injuries and aging geriatric populations continue to drive the orthopaedic implant market. A hierarchical analysis bone remodelling after material implantation is necessary better understand relationship between bone. Osteocytes, which are housed communicate through lacuno-canalicular network (LCN), integral health processes. Therefore, it essential examine framework LCN in response materials or surface treatments. Biodegradable offer an alternative...
Introduction: Synchrotron radiation micro-computed tomography (SRμCT) has been used as a non-invasive technique to examine the microstructure and tissue integration of biodegradable bone implants. To be able characterize parameters regarding disintegration osseointegration such materials quantitatively, three-dimensional (3D) image data provided by SRμCT needs processed means semantic segmentation. However, accurate segmentation is challenging using traditional automated techniques. This...
Abstract Highly accurate segmentation of large 3D volumes is a demanding task. Challenging applications like the synchrotron radiation microtomograms (SRμCT) at high-resolution, which suffer from low contrast, high spatial variability and measurement artifacts, readily exceed capacities conventional methods, including manual by human experts. The quantitative characterization osseointegration spatio-temporal biodegradation process bone implants requires reliable, very precise segmentation....
Magnesium (Mg)-based implants have re-emerged in orthopaedic surgery as an alternative to permanent implants. Literature reveals little information on how the degradation of biodegradable may introduce safety implications for patient follow-up using medical imaging. Magnetic resonance imaging (MRI) benefits post-surgery monitoring bone healing and implantation sites. Previous studies demonstrated radiofrequency (RF) heating caused by electromagnetic fields used MRI. Our investigation is...
Magnesium alloys are some of the most convenient biodegradable materials for bone fracture treatment due to their tailorable degradation rate, biocompatibility, and mechanical properties resembling those bone. Despite fact that magnesium-based implants ZX00 (Mg-0.45Zn-0.45Ca in wt.%), particular, have been shown suitable rates good osseointegration, knowledge gaps remain our understanding impact on bone’s ultrastructure. Bone is a hierarchically structured material, where not only...
The utilization of biodegradable magnesium (Mg)-based implants for restoration bone function following trauma represents a transformative approach in orthopaedic application. One such alloy, magnesium-10 weight percent gadolinium (Mg-10Gd), has been specifically developed to address the rapid degradation Mg while enhancing its mechanical properties promote healing. Previous studies have demonstrated that Mg-10Gd exhibits favorable osseointegration; however, it distinct ultrastructural...
Magnesium–silver alloys are of high interest for the use as temporary bone implants due to their antibacterial properties in addition biocompatibility and biodegradability. Thin wires particular can be used scaffolding, but determination degradation rate homogeneity using traditional methods is difficult. Therefore, we have employed 3D imaging X-ray near-field holotomography with sub-micrometer resolution study thin (250 μm diameter) Mg-2Ag Mg-6Ag wires. The were studied two states,...
Functional materials feature hierarchical microstructures that define their unique set of properties. The prediction and tailoring these require a multiscale knowledge the mechanistic interaction microstructure property. An important material in this respect is biodegradable magnesium alloys used for implant applications. To correlate relationship between nonlinear degradation process, high-resolution situ three-dimensional (3D) imaging experiments must be performed. For purpose, novel...
The Helmholtz-Zentrum Hereon is operating several tomography end stations at the beamlines P05 and P07 of synchrotron radiation facility PETRA III DESY in Hamburg, Germany. Attenuation phase contrast imaging techniques are provided as well sample environments for situ/operando/vivo experiments applications biology, medicine, materials science, etc. Very large diverse data sets with varying spatiotemporal resolution, noise levels artifacts acquired which challenging to process analyze. Here...
Magnesium-silver alloys are of high interest for the use as temporary bone implants due to their antibacterial properties in addition biocompatibility and biodegradability. Thin wires particular can be used scaffolding, but determination degradation rate homogeneity using traditional methods is difficult. Therefore, we have employed 3D imaging X-ray near-field holotomography with sub-micrometer resolution study thin (250 &mu;m diameter) Mg-2Ag Mg-6Ag wires. The were studied two states,...
The Helmholtz-Zentrum Hereon is operating imaging beamlines for X-ray tomography (P05 IBL, P07 HEMS) academic and industrial users at the synchrotron radiation source PETRA III DESY in Hamburg, Germany. high flux density coherence of enables high-resolution situ/operando/vivo experiments provides phase contrast, respectively. Large amounts 3D/4D data are collected that difficult to process analyze. Here, we report on application machine learning image segmentation including a guided...
An increasing prevalence of bone-related injuries and aging geriatric populations continue to drive the orthopaedic implant market. A hierarchical analysis bone remodelling after material implantation is necessary better understand relationship between bone. Osteocytes, which are housed communicate through lacuno-canalicular network (LCN), integral health processes. Therefore, it essential examine framework LCN in response materials or surface treatments.Biodegradable offer an alternative...