A5044474607- Enzyme Structure and Function
- Medical Imaging Techniques and Applications
- Advanced Electron Microscopy Techniques and Applications
- Protein Structure and Dynamics
- Advanced X-ray Imaging Techniques
- Hybrid Renewable Energy Systems
- Electron and X-Ray Spectroscopy Techniques
- Electric Vehicles and Infrastructure
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Integrated Energy Systems Optimization
- RNA and protein synthesis mechanisms
- Renewable Energy and Sustainability
- Computational Drug Discovery Methods
- Physics and Engineering Research Articles
- Scientific Computing and Data Management
- Characterization and Applications of Magnetic Nanoparticles
- Transportation and Mobility Innovations
- Monoclonal and Polyclonal Antibodies Research
- Magnesium Alloys: Properties and Applications
- Experimental and Theoretical Physics Studies
- Integrated Circuits and Semiconductor Failure Analysis
- Protein purification and stability
- Maritime Transport Emissions and Efficiency
- Social Acceptance of Renewable Energy
University of Stuttgart
2025
Kongsberg Satellite Services (Norway)
2024
Deutsches Elektronen-Synchrotron DESY
2019-2023
European Molecular Biology Laboratory
2009-2023
Helmholtz Association of German Research Centres
2023
Forschungszentrum Jülich
2017-2021
European X-Ray Free-Electron Laser
2021
Rutherford Appleton Laboratory
2021
Max Planck Institute for Developmental Biology
2020
Argonne National Laboratory
2008
The Collaborative Computational Project No. 4 (CCP4) is a UK-led international collective with mission to develop, test, distribute and promote software for macromolecular crystallography. CCP suite multiplatform collection of programs brought together by familiar execution routines, set common libraries graphical interfaces. has experienced several considerable changes since its last reference article, involving new infrastructure, original This which intended as general literature citation...
The usage of renewable energy sources (RESs) to achieve greenhouse gas (GHG) emission reduction goals requires a holistic transformation across all sectors. Due the fluctuating nature RESs, it is necessary install more wind and photovoltaics (PVs) generation in terms nominal power than would otherwise be required order ensure that demand can always met. In near fully RES-based system, there will times when an inadequate conventional load meet overcapacity which lead regularly being exceeded...
“Linking the power and transport sectors—Part 1” describes general principle of “sector coupling” (SC), develops a working definition intended concept to be utility international scientific community, contains literature review that provides an overview relevant papers on this topic conducts rudimentary analysis linking sectors worldwide, EU German level. The aim follow-on paper is outline approach modelling SC. Therefore, study Germany as case was conducted. This assumes high share...
Converting wind energy into ammonia (WtA) has been recognized as a promising pathway to produce "green" compared with traditional coal-based technologies. As the key part of WtA, Power-to-Ammonia (PtA) great potential facilitate usage generation. This paper proposes co-planning approach for regional resources-based industry and electric network (EN). To this end, PtA is first modeled flexible power load systems spatial temporal constraints on hydrogen supply chains (HSC). Then novel model...
Biodegradable magnesium (Mg) alloys can revolutionize osteosynthesis, because they have mechanical properties similar to those of the bone, and degrade over time, avoiding need removal surgery. However, are not yet routinely applied their degradation behavior is fully understood. In this study we investigated quantified osseointegration two biodegradable Mg based on gadolinium (Gd) at high resolution. Mg-5Gd Mg-10Gd screws were inserted in rat tibia for 4, 8 12 weeks. Afterward, rate...
<title>Abstract</title> The Small Satellite Student Society at the University of Stuttgart (KSat e.V.) has a strong history ferrofluid-based research, demonstratedthrough ISS projects PAPELL and FARGO, as well REXUS sounding rocket project FerrAS. latest endeavor, projectFINIX, is scheduled to launch on 34 in Q1 2025. Building these previously conducted missions, FINIXseeks advance solutions with future applications space systems. These novel developments hold potential toreplace...
Abstract. Melt ponds play a crucial role in modulating the energy balance of Arctic sea ice by reducing surface albedo. While is becoming younger and smoother, this raises questions about how these changes affect melt pond characteristics, as effect deformation features, such pressure ridges, on development large spatial scales remains insufficiently understood. Here, we analyze 70 km² high resolution airborne optical imagery coincided laser altimeter data from three research flights north...
The science of X-ray free-electron lasers (XFELs) critically depends on the performance laser and quality samples placed into beam. stability biological is limited key biomolecular transformations occur short timescales. Experiments in biology require a support laboratory immediate vicinity beamlines. XBI BioLab European XFEL (XBI denotes Biology Infrastructure) an integrated user facility connected to beamlines for supporting wide range experiments. was financed built by collaboration...
Abstract Highly accurate segmentation of large 3D volumes is a demanding task. Challenging applications like the synchrotron radiation microtomograms (SRμCT) at high-resolution, which suffer from low contrast, high spatial variability and measurement artifacts, readily exceed capacities conventional methods, including manual by human experts. The quantitative characterization osseointegration spatio-temporal biodegradation process bone implants requires reliable, very precise segmentation....
The performance of automated protein model building usually decreases with resolution, mainly owing to the lower information content experimental data. This calls for a more elaborate use available structural about macromolecules. Here, new method is presented that uses homologues improve quality models automatically constructed using ARP / wARP . local similarity between deposited and being built, results in longer main-chain fragments turn can be reliably docked sequence. application...
Recent developments in cryogenic electron microscopy (cryo-EM) have enabled structural studies of large macromolecular complexes at resolutions previously only attainable using crystallography. Although a number methods can already assist de novo building models into high-resolution cryo-EM maps, automated and reliable map interpretation remains challenge. Presented here is systematic study the accuracy built maps ARP / wARP . It demonstrated that local resolution good indicator...
A load frame for in situ mechanical testing is developed the microtomography end stations at imaging beamline P05 and high-energy material science P07 of PETRA III DESY, both operated by Helmholtz- Zentrum Geesthacht. The fully integrated into control system can be controlled via a feedback loop. All relevant parameters (load, displacement, temperature, etc.) are continuously logged. It compression or tensile mode applying forces up to 1 kN compatible with all contrast modalities available...
The prediction of protein 3D structures close to insertions and deletions or, more generally, loop prediction, is still one the major challenges in homology modeling projects. In this article, we developed ranking criteria selection filters improve knowledge-based predictions. These were optimized for a test data set containing 678 deletions. examples are, principle, predictable from used database with an RMSD < 1 A represent realistic situations. Four noncorrelated fragments are evaluated....
In this work we present two methods for the reranking of protein-protein docking studies. One scoring method searches InterDom database domains that are available in proteins to be docked and evaluates interaction these other complexes known structure. The second one analyzes interface each proposed conformation with regard conservation Phe, Met, Trp their polar neighbor residues. special relevance residues is based on a publication by Ma et al. (Proc Natl Acad Sci USA 2003;100:5772-5777),...
Docking algorithms are developed to predict in which orientation two proteins likely bind under natural conditions. The currently used methods usually consist of a sampling step followed by scoring step. We weighted geometric correlation based on optimised atom specific weighting factors and combined them with our previously published amino acid comprehensive SVM-based function. the yields better results than scoring. In combination functions percentage complexes for near native structure...
One of the most challenging aspects protein-protein docking is inclusion flexibility into procedure. We developed a postfilter where grid-representation proteins for extended by an optimised weighting factor each amino acid. For up to 86% evaluated complexes near-native structure was within top 5% ranked prediction output. The factors obtained optimisation procedure correlate certain extent with acids, their hydrophobicity and propensity be in interface. Use acid specific parameters yields...
A novel approach to obtaining structural information from macromolecular X-ray data extending resolutions as low 20 is presented. Following a simple map-segmentation procedure, the approximate shapes of domains forming structure are identified. pattern-recognition comparative analysis these and those derived structures PDB results in candidate models that can be used for fit into density map. It shown placed employed subsequent phase extension higher resolution.
The West-Life project (https://about.west-life.eu/) is a Horizon 2020 funded by the European Commission to provide data processing and management services for international community of structural biologists, in particular support integrative experimental approaches within field biology. It has developed enhancements existing web structure solution analysis, created new pipelines link these into more complex higher-level workflows, added facilities. Through this work it striven make benefits...
The Helmholtz-Zentrum Hereon is operating several tomography end stations at the beamlines P05 and P07 of synchrotron radiation facility PETRA III DESY in Hamburg, Germany. Attenuation phase contrast imaging techniques are provided as well sample environments for situ/operando/vivo experiments applications biology, medicine, materials science, etc. Very large diverse data sets with varying spatiotemporal resolution, noise levels artifacts acquired which challenging to process analyze. Here...