A5023203755- Magnesium Alloys: Properties and Applications
- Aluminum Alloys Composites Properties
- Marine Invertebrate Physiology and Ecology
- Venomous Animal Envenomation and Studies
- Marine Toxins and Detection Methods
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Hydrogen Storage and Materials
- Magnesium in Health and Disease
- Toxin Mechanisms and Immunotoxins
- Corrosion Behavior and Inhibition
- Glycosylation and Glycoproteins Research
- Marine Biology and Ecology Research
- Bone fractures and treatments
- Monoclonal and Polyclonal Antibodies Research
- MXene and MAX Phase Materials
- Marine and coastal plant biology
- Environmental Toxicology and Ecotoxicology
- Vitamin K Research Studies
- Galectins and Cancer Biology
- Nicotinic Acetylcholine Receptors Study
- Thallium and Germanium Studies
- Bone health and treatments
- Osteoarthritis Treatment and Mechanisms
- Transgenic Plants and Applications
Helmholtz-Zentrum Hereon
2015-2024
Institute of Materials Research of the Slovak Academy of Sciences
2019-2021
In-Q-Tel
2020
Institute of Marine and Coastal Research
2011
Bioanalytica (Switzerland)
2011
Coastal Impact
2011
Max Planck Society
2007-2010
Lower Saxony Institute for Historical Coastal Research
2003
United Nations
1948
Historically, the rapid degradation and massive gas release from magnesium (Mg) implants resulted in severe emphysema mechanical failure. With advent of new alloys surface treatment methods, optimized Mg have re-entered clinics since last decade with reliable performance. However, optimization aims at slowing down process, rather than exemption release. This study involved a systematic evaluation current preclinical clinical evidence, regarding physical signs, symptoms, radiological...
Magnesium (Mg) alloys have become a potential material for orthopedic implants due to their unnecessary implant removal, biocompatibility, and mechanical integrity until fracture healing. This study examined the
Magnesium (Mg) - based alloys are becoming attractive materials for medical applications as temporary bone implants support of fracture healing, e.g. a suture anchor. Due to their mechanical properties and biocompatibility, they may replace titanium or stainless-steel implants, commonly used in orthopedic field. Nevertheless, patient safety has be assured by finding long-term balance between metal degradation, osseointegration, ultrastructure adaptation element distribution organs. In order...
Lithium (Li), a widely used drug for bipolar disorder management, is associated with many side effects due to systemic exposure. The localized delivery of lithium through implants could be an approach overcome this challenge, which biodegradable magnesium (Mg)-based materials are promising choice. In study, we focus on Mg-Li thin film alloys as potential Li-releasing implants. Therefore, investigated the in vitro short-term corrosion behavior and cytocompatibility two alloys, Mg-1.6wt%Li...
The clinical application of magnesium (Mg) and its alloys for bone fractures has been well supported by in vitro vivo trials. However, there were studies indicating negative effects high dose Mg intake sustained local release ions on metabolism or repair, which should not be ignored when developing Mg-based implants. Thus, it remains necessary to assess the biological implants animal models relevant treatment modalities. primary purpose this study was validate beneficial intramedullary...
Rodent models are commonly used in pre-clinical research of magnesium (Mg)-based and other types biomaterials for fracture treatment. Most studies selected unstable fixation methods, there is a lack multimodal longitudinal vivo monitoring bone healing. The purpose this study to develop rat femoral model stabilized by external with intra-medullary Mg implant, investigate the dynamic union process several imaging techniques offering complementing insights into process. Pure pins were prepared,...
Magnesium and its alloys have in recent years emerged as a promising alternative to titanium‐based implants for medical applications due favorable degradation properties good biocompatibility. The of materials is currently investigated by studying different samples the same material at time points after medium. This study presenting high‐resolution time‐lapse investigation Mg‐2Ag culture medium using synchrotron radiation‐based micro‐computed tomography over course 5 days. design...
Mesenchymal stem cells (MSCs) are proliferative and multipotent that play a key role in the bone regeneration process. Empirical data have repeatedly shown bioregulatory importance of magnesium (Mg) ions MSC growth osteogenesis. In this study, we propose an agent-based model to predict spatiotemporal dynamics population osteogenic differentiation response Mg2+ ions. A fuzzy-logic controller was designed govern decision-making process by predicting four cellular processes proliferation,...
Abstract The local response of tissue triggered by implantation degradable magnesium‐based implant materials was investigated in vivo a murine model. Pins (5.0 mm length 0.5 diameter) made Mg, Mg‐10Gd, and Ti were implanted the leg muscle C57Bl/6N mice ( n = 6). Implantation generally well tolerated as documented only mild short term increase multidimensional scoring index. Lack difference between groups indicated that systemic surgery related rather than material dependent. Longitudinal...
We propose a computational framework to study the effect of corrosion on mechanical strength magnesium (Mg) samples. Our work is motivated by need predict residual biomedical Mg implants after given period degradation in physiological environment. To model corrosion, mass-diffusion type used that accounts for localised using Weibull statistics. The overall mass loss prescribed (e.g., based experimental data). behaviour samples modeled state-of-the-art Cazacu–Plunkett–Barlat plasticity with...
The interaction between organic molecules and biomaterial surfaces determines the fate of biomaterials during their service life, which is also research hotspots in field biomaterials. To understand mechanism protein with magnesium (Mg) degradation, alloying elements, immersion time, concentration surface conditions have been previously considered for effect proteins on Mg degradation. However, fluid flow, as one critical factors, drew little attention this case. In present study, bovine...
Extensive research is being conducted on magnesium (Mg) alloys for bone implant manufacturing, due to their biocompatibility, biodegradability and mechanical properties. Gadolinium (Gd) among the most promising alloying elements property control in Mg alloy implants; however, its toxicity controversial. Investigating Gd behavior during corrosion thus of utmost importance. In this study, we analyzed degradation byproducts at site biodegradable Mg-5Gd Mg-10Gd implants after 12 weeks healing...
Magnesium (Mg)-based implants have emerged as a promising alternative for orthopedic applications, owing to their bioactive properties and biodegradability. As the degrade, Mg
Fetuin is a plasma glycoprotein widely distributed in mammals. It has been used as model protein for structural analyses and investigations into the biological properties of glycoproteins. A convenient one-step procedure biospecific isolation fetuin from fetal bovine serum was developed on basis wheatgerm agglutinin (WGA) affinity separation. Two different porous supports, silica-based material polymer-based material, were immobilization WGA. The prepared WGA adsorbents characterized process...