A5080506354- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Stability and Control of Uncertain Systems
- Organ Donation and Transplantation
- Neurological Complications and Syndromes
- Pharmacological Effects and Toxicity Studies
- Transplantation: Methods and Outcomes
- Advanced Control Systems Optimization
- Adaptive Control of Nonlinear Systems
- Distributed Control Multi-Agent Systems
- Organ and Tissue Transplantation Research
- Cytomegalovirus and herpesvirus research
- Hematopoietic Stem Cell Transplantation
- Signaling Pathways in Disease
- Ovarian function and disorders
- Polyomavirus and related diseases
- Pancreatic function and diabetes
- Neural Networks Stability and Synchronization
- Network Time Synchronization Technologies
- Pregnancy and Medication Impact
- Microgrid Control and Optimization
- Liver Disease and Transplantation
- Thyroid Disorders and Treatments
- Control and Stability of Dynamical Systems
- Renal Diseases and Glomerulopathies
Universidad de Sevilla
2011-2024
Heifer International
2015
University of Tolima
2005-2012
Tecnológico de Monterrey
2012
Pontificia Universidad Javeriana
2011
Abdelmalek Essaâdi University
2011
University of Pittsburgh
1995-2008
Allegheny General Hospital
2005
University of Pittsburgh Medical Center
1995-2003
Children's Hospital of Pittsburgh
2003
Background. Asymptomatic polyoma virus infection documented by urine cytology or serology is well known, but the clinical course of biopsy-proven interstitial nephritis not defined. Methods. Twenty-two cases were identified histology, immunostaining, in situ hybridization, electron microscopy, polymerase chain reaction. Results. The features mimicked acute rejection (n=19), chronic with incidental diagnosis at nephrectomy (n=2), drug toxicity (n=1). Histology showed homogenous intranuclear...
Magnone, Mario; Holley, Jean L.; Shapiro, Ron; Scantlebury, Velma; McCauley, Jerry; Jordan, Mark; Vivas, Carlos; Starzl, Thomas; Johnson, John P. Author Information
Between March 27, 1989 and December 31, 1997, 1316 kidney transplantations alone were performed under tacrolimus-based immunosuppression at our center. Posttransplant lymphoproliferative disorders (PTLD) developed in 25 (1.9%) cases; the incidence adults was 1.2% (15/1217), whereas pediatric patients it 10.1% (10/99; P<.0001). PTLD diagnosed 21.0±22.5 months after transplantation, 25.0±24.7 14.4±18.2 patients. Of 4 adult cases whom both donor recipient Epstein Barr virus (EBV) serologies...
Kidney biopsies are being used to evaluate marginal donors, but rigorous statistical validation of this practice with multivariate analysis has not been performed.To analyze histologic parameters in 78 donor for their ability predict graft dysfunction, we a proportional odds model that included both and recipient factors. Glomerulosclerosis was categorized into grades 0, 1, 2, 3, corresponding 1-10%, 11-20%, 21-30% global sclerosis, respectively. The degrees interstitial fibrosis, tubular...
A group of 204 adult patients was entered into a prospective, randomized trial comparing FK506/prednisone with FK506/azathioprine/prednisone after renal transplantation between August 1, 1991 and October 11, 1992. The purpose the study to see if addition azathioprine would reduce incidence rejection improve graft survival. recipient population unselected, 61 (30%) undergoing retransplantation, 37 (18%) having panel-reactive antibody greater than 40%, 33 (16%) over 60 years age. mean age...
Kidneys from older donors exhibit a series of changes characterized by glomerular, vascular, and tubular senescence. These may be aggravated atherosclerosis, hypertension, or diabetes, which are highly prevalent in individuals.We analyzed the outcome after transplantation 230 recipients over age 60, who received transplants between February 1990 December 1996. We assessed 1- 5-year patient graft survival, quality renal function, tacrolimus levels, incidence rejection, delayed compared...
Over the 5 year period from 7/14/1989 until 5/24/1994, we have attempted graft salvage with tacrolimus conversion in a total of 169 patients (median age 33 years, range 2-75 years) ongoing rejection on baseline CsA immunosuppression after failure high dose corticosteroids and/or antilymphocyte preparations to reverse rejection. The indications for were ongoing, biopsy confirmed all patients. median interval was 2 months (range days 55 months; mean 4.3±2.6 months) transplantation. All had...
To investigate the possibility that we have been underestimating true incidence of acute rejection, began to perform protocol biopsies after kidney transplantation. This analysis looks at one-week biopsies. Between March 1 and October 1, 1999, 100 adult patients undergoing cadaveric or kidney/pancreas transplantation, living donor underwent 277 We focused on subset in without delayed graft function (DGF) with stable improving renal function, who a biopsy 8.2+/-2.6 d (range 3-18 d)...
Background. Despite the recent advances in immunosuppression, steroid-resistant rejection remains a difficult problem renal transplant recipients. Methods. We reviewed our experience with i.v. immunoglobulin (IVIG) treatment of steroid- and antilymphocyte antibody-resistant patients. Between September 1996 March 1999, 17 patients were treated IVIG to reverse or rejection. A total 2 g/kg was administered during each course. Results. With mean follow-up 21.5±9.5 months from time...
The authors reviewed their long-term experience with pediatric renal transplantation into a dysfunctional lower urinary tract to evaluate the results of contemporary evaluation and management on graft survival function.Between 1990 1996, 21 transplants were performed in 20 children tracts 61 patients normal tracts. minimum follow-up was 36 months (mean, 62.0 +/- 19.6 months). cause dysfunction included posterior urethral valves (n=13), prune belly syndrome (n=4), meningomyelocele (n=2),...
Background. Tacrolimus has been used as a primary immunosuppressive agent in adult and pediatric renal transplant recipients, with reasonable outcomes. Methods. Between December 14, 1989 31, 1996, 82 transplantations alone were performed under tacrolimus-based immunosuppression without induction anti-lymphocyte antibody therapy. Patients undergoing concomitant or prior liver and/or intestinal transplantation not included the analysis. The mean recipient age was 10.6±5.2 years (range:...
This study was designed to (a) estimate the contribution of tacrolimus nephrotoxicity episodes renal allograft dysfunction investigated by needle biopsy, (b) describe temporal evolution and its response therapy, (c) ascertain how often is associated with concurrent extra‐renal toxicity. Patients were selected based on a rising serum creatinine, normal ultrasound, biopsy findings leading reduction in dose fall creatinine. Twenty two (17%) cases identified amongst 128 consecutive kidney...
Background The Banff Schema suggests the term “borderline changes” for biopsies showing changes insufficient a diagnosis of mild acute rejection. appropriate clinical management patients such on biopsy is controversial. Methods We reviewed course and response to antirejection therapy 24 with borderline changes, compared our findings those obtained from 14 Patients were classified as complete response, partial or no treatment, depending whether posttreatment fall in serum creatinine was >70%,...
Objective The effect of donor bone marrow was evaluated for its potentially favorable in the authors' simultaneous pancreas/kidney transplant program. Methods From July 1994 to January 1999, 177 pancreas transplants were performed, 151 which transplants. All patients received tacrolimus, mycophenolate mofetil, and steroids immunosuppression (azathioprine used first year program). Fifty-three recipients perioperative unmodified marrow, 3 6 × 108 cells/kg. Results Overall actuarial survival...
This paper's aim is to present a novel design technique for distributed estimation in networked systems. The problem assumes network of interconnected agents each one having partial access measurements from linear plant and broadcasting their estimations neighbours. objective reach reliable the state every agent location. observer's structure implemented based on local Luenberger-like observers combination with consensus strategies. paper focuses following related issues: delays, packet...
Purpose. The results of steroid withdrawal in pancreas transplant recipients under tacrolimus immunosuppression were analyzed. Methods. From July 4, 1994 until April 30, 1998, 147 transplantations performed 141 patients, including 126 simultaneous pancreas-kidney transplantations, 13 after kidney transplantation, and 8 alone. Baseline consisted steroids without antilymphocyte induction. Twenty-three patients excluded from analysis because early graft loss 17 cases, retransplantation 5...
Corticosteroids have always been an integral part of immunosuppressive regimens in renal transplantation. The primary goal this analysis was to assess the safety steroid withdrawal our pediatric transplant recipients receiving tacrolimus-based immunosuppression.Between December 1989 and 1996, 82 transplantations were performed patients immunosuppression. Two these lost their grafts within 3 weeks transplantation (and still on steroids at time graft loss), excluded from further analysis....
Background. The long-term safety and efficacy of tacrolimus in pancreas transplantation has not yet been demonstrated. observation prolonged pancreatic graft function under would indicate that any potential islet toxicity is short-lived clinically insignificant. We report herein the results patients receiving primary immunosuppression for a minimum 2 years. Methods. From July 4, 1994 until April 18, 1996, 60 received either simultaneous pancreas-kidney transplant (n=55), only (n=4), or after...