A5071167616- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Synthesis and Biological Evaluation
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Peptidase Inhibition and Analysis
- Fungal Biology and Applications
- Phytochemistry and Bioactive Compounds
- Microbial Natural Products and Biosynthesis
- Histone Deacetylase Inhibitors Research
- Synthesis and biological activity
- Plant Pathogens and Fungal Diseases
- Protein Degradation and Inhibitors
- Phytochemical compounds biological activities
- Synthesis of heterocyclic compounds
- Pharmacological Receptor Mechanisms and Effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Phytochemistry and biological activities of Ficus species
- Plant chemical constituents analysis
- Ginger and Zingiberaceae research
- Phytochemical Studies and Bioactivities
- Plant-Microbe Interactions and Immunity
- Traditional Chinese Medicine Analysis
- Heavy Metals in Plants
- Phenothiazines and Benzothiazines Synthesis and Activities
Tafila Technical University
2010-2025
University of Mississippi
2013-2021
Bioassay-guided fractionation of Cladosporium cladosporioides (Fresen.) de Vries extracts led to the isolation four compounds, including cladosporin, 1; isocladosporin, 2; 5′-hydroxyasperentin, 3; and cladosporin-8-methyl ether, 4. An additional compound, 5′,6-diacetylcladosporin, 5, was synthesized by acetylation compound 3. Compounds 1–5 were evaluated for antifungal activity against plant pathogens. Phomopsis viticola most sensitive fungus tested compounds. At 30 μM, 1 exhibited 92.7,...
<title>Abstract</title> Histone deacetylase (HDAC) inhibitors represent a newer class of anti-cancer agents that play key role in both epigenetic and non-epigenetic regulation, leading to cancer cell death, apoptosis, cycle arrest.. These are being tested numerous clinical trials against various diseases, including hematological solid malignancies. In the present study, we synthesized novel bicyclic hydroxamic acid derivatives them vitro I IIb HDACs investigate their inhibitory activity...
Bioassay-guided fractionation of the leaves Perovskia atriplicifolia (Russian sage) resulted in isolation four previously known flavonoid derivatives, 5-hydroxy-6,7,3′,4′-tetramethoxyflavone (1), 5,7-dihydroxy-6,3′,4′-trimethoxyflavone (2), 5-hydroxy-6,7,4′-trimethoxyflavone (3), and 5,7-dihydroxy-6,4′-dimethoxyflavone (4). Compounds 1, 3, 4 showed displacement radioligand for cloned human δ opioid receptor with Ki values ranging from 3.1 to 26.0 μM. In addition, binding mode compounds...
Essential oils (EOs) are complex mixtures of several components that show a wide range biological activities. The objective the present work was to investigate composition essential from industrial large-scale distillation, and evaluate their antimicrobial activity on typical clinic isolates strains. qualitative compositions aromatic plants were determined by GC-FID after distillation (Calendula Co., Nova Lubovna, Slovakia). analysis revealed different quantitative content in comparison with...
A new polyketide derivative koninginin H (1), has been isolated from the fungus Emericella nidulans, together with E (2), (3), trichodermatide B (4), citrantifidiol (5), (4S,5R)-4-hydroxy-5-methylfuran-2-one (6), glycerol derivatives gingerglycolipid (7), (2S)-bis[9Z,12Z]-1-O, 2-O-dilinoleoyl-3-O-[alpha-D-galactopyranosyl-(1" --> 6') beta-D-galactopyranosyl]glycerol (8), 2-O-dilinoleoyl-3-O-beta-D-galactopyranosylglycerol (9), cerebroside flavuside (10), and known sterols beta-sitosterol...
In this research, composites of layered double hydroxide (LDH) with three Jordanian natural raw materials; Tripoli (T), Pozzolana (P) and Feldspar (F) were prepared by co-precipitation have been used for feed seawater pre-treatment. The data reveals that percent adsorption decreased increase in initial concentration, but the actual amount adsorbed ions per unit mass LDH/T-P-F increased metal ion concentrations. values ?Go negative within 21 to 26 KJ/mol, while ?Ho ?So positive range 0.1 25...
A new series of substituted ethyl 7-cyclopropyl-2-(2-aryloxo)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylates 3a–e were prepared by utilizing 2-chloro-7-cyclopropyl-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate (1) and replacing the 2-chlorine with anions obtained from phenol (2a), salicylaldehyde derivatives 2b–d or thiophenol (2e), leading to respective 3a–e. The compounds evaluated for their in vitro cytotoxicity towards sensitive CCRF-CEM multidrug-resistant...
Lichens have widely been used as bioindicators to reflect the quality of environment. The present study was conducted investigate lichens diversity that grows on surface waste heaps from an abandoned old copper mine in Mlynky, Slovakia. In spite heavy metalcontaminated environment, we documented twenty species selected site. Taxonomically most numerous group were represented by Cladonia with seven species, well other species; namely, Acarospora fuscata, Cetraria islandica, Dermatocarpon...
The cannabinoid receptor 2 (CB2 receptor) has attracted considerable interest, mainly due to its potential as a target for therapeutics treating various diseases that have neuroinflammatory or neurodegenerative component while avoiding the adverse psychotropic effects accompany CB1 receptor-based therapies. With appreciation CB2-selective ligands show marked functional selectivity, there is renewed opportunity explore this promising area of research from both mechanistic well therapeutic...
Medicinal plants have been used for longtime treatment of many illnesses. Many were described in folk heritage to anti-inflammatory activity treat digestive diseases. In this study, thirteen commonly by Jordanian folks disorders investigated find a connection between their contents and activities relationship with assigned use. The ethanolic extracts the tested Total Phenolic Content (TPC), Tannin (TTC), Flavonoid (TFC) antioxidants using 2,2-diphenyl-1-picrylhydrazyl (DPPH) 2,2'-azino-bis...
Bioassay-guided fractionation of the EtOAc extracts epiphytic fungus Emericella nidulans resulted in isolation a mixture two fatty acids. This showed 98% binding affinity to human δ opioid receptor. These acids were identified as palmitic (PAM), 1, and linoleic (LNA), 2, by 1D NMR well GC/MS analysis, after their methylation. We found that different ratio mixtures 1 2 variations selective activities receptors. Five more acids, arachidonic acid (ARA), 3, cis-4,7,10,13,16,19-docosahexanoic...
This study was carried out to investigate the heavy metal contaminants (cadmium, lead, copper, zinc, manganese and iron) found in potato corn chips being sold Jordanian market, estimate their health risk on consumers. The reason behind this that are widely consumed by most children over world. Atomic Absorption Spectrometry used measure levels of metals after wet digestion, then dietary intake each estimated based means children. Also, level evaluated with respect value Minimal Risk Level....
Plant tissues typically contain a diverse complement of secondary metabolites that provide protection against various biotic and abiotic hazards. In this work phytochemical constituents three Limonium species (L. myrianthum, L. leptophyllum gmelinii) were elucidated characterized. Chemical similarities among the observed; however, each displayed its differences. Myricetin myricetin-3-O-L-rhamnopyranoside are present in all species, while myricetin 3-O-(6″-galloylglucoside),...