A5086648859- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Food Security and Health in Diverse Populations
- Prenatal Screening and Diagnostics
- Pharmacological Effects and Toxicity Studies
- Neonatal Health and Biochemistry
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Emergency and Acute Care Studies
- Palliative Care and End-of-Life Issues
- Childhood Cancer Survivors' Quality of Life
- Healthcare Policy and Management
- Adolescent and Pediatric Healthcare
- Autopsy Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Homelessness and Social Issues
- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Gout, Hyperuricemia, Uric Acid
- Genetic Neurodegenerative Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Meta-analysis and systematic reviews
- Cardiac Arrest and Resuscitation
- Diabetes Treatment and Management
Boston Medical Center
2014-2024
Boston University
2014-2024
EBSCO Industries (United States)
2020
University Medical Center
2019
Mater Misericordiae University Hospital
2017
Mater Hospital
2015
SUNY Downstate Health Sciences University
2012
Mount Sinai Beth Israel
2007
Columbia University
2007
Merck & Co., Inc., Rahway, NJ, USA (United States)
2004
OBJECTIVE To estimate direct medical costs of managing the complications type 2 diabetes. RESEARCH DESIGN AND METHODS Costs were estimated for 15 diabetic by applying unit to typical resource-use profiles. Resource use and from many sources, including acute care discharge databases, clinical guidelines, government reports, fee schedules, peer-reviewed literature. For each complication, event are those associated with resource that is specific episode any subsequent occurring in 1st year....
There are no current national estimates on health care utilization and expenditures for US children with sickle cell disease (SCD).We used the MarketScan Medicaid Database Commercial Claims Encounters 2005 to estimate services use expenditures. The final samples consisted of 2,428 Medicaid-enrolled 621 privately insured SCD.The percentage SCD enrolled in an inpatient admission was higher compared those (43% vs. 38%), yet mean per were 35% lower ($6,469 $10,013). number emergency department...
Vaso-occlusive episodes (VOEs) account for the majority of emergency department (ED) visits children with sickle cell disease (SCD). We hypothesized that addressing key barriers to VOE care would improve receipt analgesics and outcomes.A quality improvement (QI) initiative was conducted from September 2010 April 2014 streamline in an urban pediatric ED. Four interventions were used: a standardized time-specific protocol; intranasal fentanyl as first parenteral pain medication; SCD medication...
OBJECTIVE. In this we study explored the relationship between food insecurity and compensatory maternal feeding practices that may be perceived as buffers against periodic shortages among urban black families. METHODS. We interviewed a convenience sample of mothers children aged 2 to 13 years. Food-security status (predictor) was determined at household level. Five (outcomes) were assessed. Two based on Birch's Child Feeding Questionnaire (restricting access certain foods pressuring child...
In the US, all states and District of Columbia have universal newborn screening (NBS) programs for sickle cell disease (SCD), which also identify trait (trait). this project, we surveyed follow-up coordinators, including one in two Georgia, about protocols stakeholder notification SCD trait. The primary outcomes were total number type informed a positive screen. We received 52 completed surveys (100% response). Primary care providers (PCPs) (100%), hematologists (81%), hospitals (73%),...
Background: Pasteurized human donor milk (DM) is recommended by the World Health Organization and American Academy of Pediatrics for preterm infants when mother’s own unavailable, yet extent predictors use criteria in US neonatal intensive care units (NICUs) are unknown. Objective: This study aimed to evaluate current DM level 3 NICUs use. Methods: We sent mail surveys 302 NICU directors. used multivariable logistic regression analyze Results: Survey response rate was 60%, 76 182 (42%)...
The DYT6 gene for primary torsion dystonia (PTD) was mapped to chromosome 8p21-q22 in two Amish-Mennonite families who shared a haplotype of marker alleles across 40 cM linked region. objective this study narrow the region, clinically characterize larger cohort, and determine whether is associated with newly ascertained multiplex families. We systematically examined familial cases, identifying five additional members from original families, as well three other evaluated known recombination...
Historically, many children and adolescents with sickle cell disease (SCD) were underweight. Treatment advances like hydroxyurea have been associated improved growth. We hypothesized that increased hemoglobin (Hb) levels would be weight status of SCD.Investigators at 6 institutions conducted a retrospective chart review all patients aged 2 to 19 years age for the calendar 2007-2009. Height, weight, baseline Hb levels, demographic information, select comorbidities recorded from most recent...
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Abstract For Black children with sickle cell disease (SCD) and their families, high stigmatization pervasive racism increase susceptibility to discrimination in healthcare settings. Childhood experiences of can result medical nonadherence, mistrust providers, poorer health outcomes across the lifespan. Caregivers providers are essential childhood SCD management therefore well-positioned provide insight into context pediatric SCD. This mixed-methods study sought caregivers’ providers’...
Background Children with sickle cell disease (SCD) are at increased risk of complications from influenza. However, despite widespread recommendations that these patients receive an annual influenza immunization, reported vaccination rates remain very low under 50%. Procedure Our aim was to increase the rate among our pediatric SCD aged 6 months 21 years over two seasons, 2012–2013 and 2013–2014, 80%, consistent Health People 2020 goal. We used multiple quality improvement methods, based on...
Abstract Background Vaso‐occlusive crises (VOCs) cause debilitating pain and are a common of emergency department (ED) visits, for people with sickle cell disease (SCD). Strategies achieving optimal control vary widely despite evidence‐based guidelines. We tested existing guidelines hypothesized that patient‐specific protocol (PSP) written by their SCD provider may be more effective than weight‐based (WB) dosing parenteral opiate medication, in relieving pain. Methods This study was...
Abstract Despite the recent advances made in care of children with sickle cell disease (SCD), premature mortality, especially among older and young adults, remains a hallmark this disease. The lack survival gains highlights translational gap implementing innovations found efficacious controlled trial setting into routine clinical practice. Health services research (HSR) examines most effective ways to finance, organize, deliver high quality an equitable manner. To date, HSR has been...
Patients with gout have an increased risk of cardiovascular events. The glycoprotein VI (GPVI) receptor is found exclusively on platelets and megakaryocytes, proteolytically cleaved upon platelet activation, detectable in plasma as soluble GPVI (sGPVI). Therefore, elevated sGPVI a marker activation for aim this study was to assess measured by level gout.Blood samples were taken from patients or osteoarthritis, healthy volunteers. Demographic clinical data collected all participants. Blood...
Objectives: Contraception use reduces teen pregnancy, and long-acting reversible contraception is recommended as first-line treatment. Since many adolescents the emergency department (ED) a primary source of health care, it potential site contraceptive counseling provision. We surveyed female to assess desire for initiation/change during an ED visit. Materials Methods: This was cross sectional study convenience sample patients aged 16-21 years in urban pediatric ED. Participants completed...
The purpose of this study was to assess pediatric hematology clinic staff's perspectives regarding barriers and facilitators in addressing unmet basic needs for children with sickle cell disease (SCD).Six focus groups were held at four urban clinics the Northeastern region United States from November December 2019. Discussion questions developed align integrated Promoting Action on Research Implementation Health Services (i-PARIHS) implementation science framework, focusing domains context...