A5081876330- Oral microbiology and periodontitis research
- Dental Implant Techniques and Outcomes
- Bone Metabolism and Diseases
- Bone Tissue Engineering Materials
- Childhood Cancer Survivors' Quality of Life
- Diabetes Management and Research
- Dental materials and restorations
- Adolescent and Pediatric Healthcare
- Vagus Nerve Stimulation Research
- Heart Rate Variability and Autonomic Control
- Orthopaedic implants and arthroplasty
- Immune Response and Inflammation
- Neuroscience of respiration and sleep
- Oral Health Pathology and Treatment
- Endodontics and Root Canal Treatments
- Bone and Dental Protein Studies
- Nigella sativa pharmacological applications
- Periodontal Regeneration and Treatments
- Nicotinic Acetylcholine Receptors Study
- Inflammatory mediators and NSAID effects
- Ethics in Clinical Research
- Mobile Health and mHealth Applications
- Effects of Radiation Exposure
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
University of California, Los Angeles
2011-2023
APLA Health
2023
Children's Hospital of Los Angeles
2022-2023
Texas Cardiac Arrhythmia
2018
Texas Tech University
2009
Abstract Heart rate is under the precise control of autonomic nervous system. However, wiring peripheral neural circuits that regulate heart poorly understood. Here, we develop a clearing-imaging-analysis pipeline to visualize innervation intact hearts in 3D and employed multi-technique approach map parasympathetic sympathetic mice. We identify cholinergic neurons noradrenergic an intrinsic cardiac ganglion stellate ganglia, respectively, project sinoatrial node. also report response...
Aim To evaluate the effects of metformin (Met) on inflammation, oxidative stress, and bone loss in a rat model ligature-induced periodontitis. Materials & methods Male albino Wistar rats were divided randomly into five groups twenty-one each, given following treatments for 10 days: (1) no ligature + water, (2) (3) 50 mg/kg Met, (4) 100 (5) 200 Met. Water or Met was administered orally. Maxillae fixed scanned using Micro-computed Tomography (μCT) to quantitate linear volume/tissue volume...
Abstract Aim Peri‐implantitis ( PI ), inflammation around dental implants, shares characteristics with periodontitis PD ). However, is more difficult to control and treat, detailed pathophysiology unclear. We aimed compare progression utilizing a murine model. Materials Methods Four‐week‐old male C57 BL /6J mice had their left maxillary molars extracted. Implants were placed in healed extraction sockets osseointegrated. Ligatures tied the implants second molars. Controls did not receive...
Objective The aim of this study was to evaluate the effects gliclazide on oxidative stress, inflammation, and bone loss in an experimental periodontal disease model. Material Methods Male albino Wistar rats were divided into no ligature, ligature with 1, 5, 10 mg/kg groups. Maxillae fixed scanned using micro-computed tomography quantify linear volume/tissue volume (BV/TV) volumetric loss. Histopathological, immunohistochemical immunofluorescence analyses conducted examine matrix...
Background and Objective Peri‐implantitis has a prevalence of 11–47%, involves destruction peri‐implant bone may lead to implant loss. A detailed understanding the pathogenesis peri‐implantitis is lacking. The objective this study was develop murine model experimental peri‐implantitis. Material Methods Machined, smooth‐surface, screw‐shaped titanium implants were placed in healed alveolar left maxillary molars C57 BL /6J male mice, 8 wk after tooth extraction. induced by securing silk...
Abstract Background Peri‐implantitis is an inflammatory response to bacterial biofilm resulting in bone loss and can ultimately lead implant failure. Because of the lack predictable treatments available, a thorough understanding peri‐implantitis's pathogenesis essential. The objective this study evaluate compare acute induced peri‐implantitis periodontitis lesions after insult removal. Methods Implants were placed one‐month‐old C57BL/6J male mice eight weeks post extraction their left...
Background: Adolescents and young adults (AYA) from diverse marginalized backgrounds with type 1 diabetes (T1D) generally have higher hemoglobin A1c (HbA1c) levels less frequent continuous glucose monitor (CGM) use than AYA more privileged backgrounds. Further, scant data address the impact of virtual peer groups (VPG) on health-related outcomes for ethnically racially T1D. Methods: CoYoT1 to California was a 15-month randomized controlled trial aged 16-25 years. In this study, were receive...
Dental implants are a widely used treatment option for tooth replacement. However, they susceptible to inflammatory diseases such as peri-implant mucositis and peri-implantitis, which highly prevalent may lead implant loss. Unfortunately, the understanding of pathogenesis peri-implantitis is fragmented incomplete. Therefore, availability reproducible animal model study these would facilitate dissection their pathogenic mechanisms. The objective this propose murine experimental...
Background Periodontitis is an inflammatory disease of the periodontal tissues that compromises tooth support and can lead to loss. Although bacterial biofilm central in pathogenesis, host response plays important role progression severity periodontitis. Indeed, clinical genetic studies indicate periodontitis 50% heritable. In this study, we hypothesized lipopolysaccharide ( LPS) injections a strain‐dependent bone loss pattern. Material methods We utilized five inbred mouse strains derive...
Background: Type one diabetes (T1D) management is challenging for adolescents and young adults (AYAs) due to physiological changes, psychosocial challenges, increasing independence, resulting in increased distress hemoglobin A1c (HbA1c). Alternative care models that engage AYAs improve diabetes-related health outcomes are needed. Methods: A 15-month study evaluated an adaptation of the Colorado Young Adults with T1D (CoYoT1) Care model. CoYoT1 includes person-centered care, virtual peer...
Peri-implantitis is defined as an inflammatory disease affecting the tissues around osseointegrated functioning implants. Unfortunately, detailed peri-implantitis pathogenesis not well understood and current treatments lack predictability. Compare healing potential of late-stage ligature-induced periodontitis after ligature removal. Four-week-old C57BL/6J male mice had their left maxillary molars extracted. After 8 weeks, implants were placed in healed sockets allowed to osseointegrate. Mice...
ABSTRACT Periodontitis (PD) is characterized by bacterial infection and inflammation of tooth-supporting structures can lead to tooth loss. PD affects ∼47% the US population over age 30 years has a heritability about 50%. Although host immunoinflammatory response genetic background play role, little known underlying factors. We examined natural variation in lipopolysaccharide (LPS)-induced across panel inbred mouse strains, hybrid diversity (HMDP). observed strain-dependent sixfold...
Peri-implantitis (PI) is an inflammatory condition that affects the tissues surrounding dental implants. Although pathogenesis of PI not fully understood, evidence suggests etiology multifactorial and may include a genetic component. The aim this study was to investigate role genetics in development peri-implantitis.Four-week-old C57BL/6J, C3H/HeJ A/J male mice had their left maxillary molars extracted. Implants were placed healed extraction sockets. Upon osseointegration, ligatures around...
This study aimed to assess if
Abstract Heart rate is under the precise control of autonomic nervous system. However, wiring peripheral neural circuits that regulate heart poorly understood. Here, we developed a clearing-imaging-analysis pipeline to visualize innervation intact hearts in 3D and employed multi-technique approach map parasympathetic sympathetic mice. We anatomically functionally identify cholinergic neurons noradrenergic an intrinsic cardiac ganglion stellate ganglia, respectively, project sinoatrial node....
Background: The prevalence of type 1 diabetes (T1D) is increasing within racially and ethnically marginalized populations, highlighting the need for effective recruitment strategies that not only address healthcare disparities but also rebuild trust in medical research. Recently, CoYoT1 to California (CTC) study evaluated a person-centered care model designed support diverse young adults (YA) who receive at hospital-based pediatric T1D clinic. In addition treatment effectiveness, examined...
Abstract Sarcoma is a cancer which originates in the body's connective tissues of mesenchymal origin. These are like bones and muscles that support or protect other parts body. About ~16,000 sarcomas diagnosed annually US, with ~6,700 deaths attributed to disease. Sarcomas typically divided into two major groups: bone soft-tissue sarcomas, each has multiple subtypes. However, because their diversity site-of-origin, vary greatly presentation histological features. Based on The World Health...