A5020062220- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- Cytomegalovirus and herpesvirus research
- Cell death mechanisms and regulation
- Viral Infections and Immunology Research
- Pancreatic function and diabetes
- Silymarin and Mushroom Poisoning
- Herbal Medicine Research Studies
- Systemic Lupus Erythematosus Research
- interferon and immune responses
- Respiratory viral infections research
- Immune Response and Inflammation
- Drug-Induced Hepatotoxicity and Protection
- Bioactive Natural Diterpenoids Research
- Psoriasis: Treatment and Pathogenesis
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- 3D Printing in Biomedical Research
- Animal Disease Management and Epidemiology
- Viral-associated cancers and disorders
- Hepatitis Viruses Studies and Epidemiology
- Immunodeficiency and Autoimmune Disorders
Tehran University of Medical Sciences
2014-2025
University of Tehran
2023-2024
Imam Khomeini Hospital
2021-2023
Sarem Cell Research Center
2021
Iran University of Medical Sciences
2019
Shiraz University of Medical Sciences
2017-2018
Silymarin is a polyphenolic flavonoid extracted from milk thistle. It has potent immunomodulatory effects and can inhibit the replication of influenza A virus (IAV). The present study aimed to determine inflammatory anti‐inflammatory cytokine secretion patterns in mice before after silibinin treatment. For this, bronchoalveolar lavage (BAL) fluids were collected thoracic cavity 5 days intervention, viral quantification was performed using TaqMan Real‐time PCR. Enzyme‐linked immunosorbent...
The increased levels of blood cytokines is the main immunopathological process that were attributed to severe clinical outcomes in cases influenza A, B and people with influenza-like illness (ILI). Functional genetic polymorphisms caused by single nucleotide (SNPs) inflammatory genes can influence their functions either qualitatively or quantitatively, which associated possibility infections. aim present case-control study was investigate association patients ILI group an Iranian population....
Renal cell carcinoma (RCC) accounts for the majority of cancer-related deaths worldwide. Overexpression CD70 has been linked to advanced stages RCC. Therefore, this study aims develop a multiepitope vaccine targeting overexpressed using immunoinformatics techniques. In investigation, in silico vaccines were constructed by linking specific protein epitopes helper T lymphocytes and CD8+ lymphocytes. To enhance immunogenicity, sequences cell-penetrating peptide (CPP), penetratin (pAntp), along...
Context: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by autoreactive antibodies. Recent findings revealed the importance of innate immune responses, especially Toll-like receptors (TLRs) in pathogenesis SLE.Objective: In this study, level TLR9 expression on peripheral blood mononuclear cells (PBMCs) was analyzed. The levels produced IFN-α were also measured supernatant PBMCs from SLE patients and healthy controls after stimulation with CpG ODN2216 which...
Human influenza A viruses (IAVs) cause global pandemics and epidemics, which remains a nonignorable serious concern for public health worldwide. To combat the surge of viral outbreaks, new treatments are urgently needed. Here, we design vaccine based on virus-like particles (VLPs) show how intranasal administration this triggers protective immunity, can be exploited development therapies. H1N1 VLPs were produced in baculovirus vectors injected into BALB/c mice by intramuscular (IM) or (IN)...
Background: Cancer is one of the most significant causes death. Plants with anti-cancer effects have shown to eliminate tumor cells by induction apoptosis. Objectives: The present study aimed at investigating apoptotic 3 Euphorbia native species (E. microciadia Boiss, E. osyridea and heteradenia Jaub. & Sp.). Methods: Cell lines strongest sensitivity extracts including HeLa for microciadia, K562 heteradenia, Fen were investigated plants' hexane on apoptosis, according annexin V/propidium...
Skin rash is one of the most common complications during childhood. Viral agents play an essential role in development such symptoms. Present study aims to determine prevalence and genetic variability Human Herpesvirus 6 7 (HHV-6 HHV-7) infections their subtypes children under 5 years age with skin negative for rubella measles. We used serum throat swap samples from 196 fever. ELISA IFA tests were performed detect antibodies against HHV6/7. Sequencing was using Sanger sequencing, BioEdit...
Mechanisms underlying the systemic lupus erythematosus (SLE) have not yet been elucidated. In this study, we evaluated balance of T cell subsets in BALB/c mice model SLE induced; using Con A and polyamines as DNA immunogenicity modifiers. were immunized subcutaneously with 50 µg extracted from cells cultured different conditions: splenocytes+ (group P), A), polyamines+ PA) splenocytes only (control). Anti-double-stranded -(ds-DNA) antibodies, proteinuria, antinuclear autoantibodies assessed...