A5008675504- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Atomic and Subatomic Physics Research
- Welding Techniques and Residual Stresses
- MRI in cancer diagnosis
- Neutrino Physics Research
- Quantum, superfluid, helium dynamics
- Nuclear Physics and Applications
- Radiation Detection and Scintillator Technologies
- Brain Metastases and Treatment
- Pancreatic and Hepatic Oncology Research
- Particle Accelerators and Free-Electron Lasers
- Lung Cancer Research Studies
- Particle physics theoretical and experimental studies
- Magnetic confinement fusion research
- Ultrasound and Hyperthermia Applications
- Advanced X-ray Imaging Techniques
- Quantum Chromodynamics and Particle Interactions
- Nanoplatforms for cancer theranostics
- Surface Roughness and Optical Measurements
- Polyomavirus and related diseases
- Machine Learning in Materials Science
Medical College of Wisconsin
2015-2024
Radiation Oncology Associates
2023
Tulane University
2021
Indiana University Bloomington
2009-2017
Elekta (Sweden)
2015
Marquette University
2015
Indiana University
2011
University of Tennessee at Knoxville
2003
The aCORN experiment measures the neutron-decay electron-antineutrino correlation ($a$ coefficient) using a novel method based on an asymmetry in proton time-of-flight for events where beta electron and recoil are detected delayed coincidence. We report data analysis result from second run at NIST Center Neutron Research, high-flux cold neutron beam new NG-C guide end position:...
Background and purposeCT scan protocols are often created with imaging parameters set to minimize dose acceptable image quality for diagnostic purpose. This study aimed optimize CT help accurately delineate structures radiation therapy planning delivery guidance.Materials methodsImaging were optimized data acquired a phantom create enhancement (IQE) protocols, which subsequently used prostate pancreatic cancer patient who underwent image-guided radiotherapy (IGRT). The images compared those...
This study first aims to show that the values of texture features extracted from phantoms are stable over clinical timescales. Second, changes in patients' feature course radiation therapy (RT) treatment induced and statistically significant.The CT datasets a 3D printed anatomically informed phantom containing liver low-contrast modules, homogeneous module Catphan 500-Series phantom, were acquired once per week 6-week period, simulate timescale conventional RT duration. A Definition AS Open...
We present the advantages of using dual-energy CT (DECT) for radiation therapy (RT) planning based on our clinical experience.DECT data acquired 20 representative patients different tumor sites and/or situations with dual-source simultaneous scanning (Drive, Siemens) and single-source sequential (Definition, 80 140-kVp X-ray beams were analyzed. The used to derive iodine maps, fat mono-energetic images (MEIs) from 40 190 keV exploit energy dependence attenuation. these DECT-derived RT...
Purpose: Substantial intrafraction organ motion during radiation therapy (RT) for pancreatic cancer is well recognized as a major limiting factor accurate delivery of RT. The aim this work to determine the feasibility monitoring intrafractional pancreas or surrounding structures using ultrasound RT delivery. Methods: Transabdominal (TAUS) and 4DCT data were acquired on ten patients process in prospective study. In addition, TAUS MRI collected five healthy volunteers. portal vein (PV) head...
Four-dimensional computed tomography (CT) images are typically used to quantify the necessary internal target volumes for thoracic and abdominal tumors. However, 4-dimensional CT is associated with excessive imaging dose patients situation exacerbated when using repeat on a weekly or daily basis throughout fractionated therapy. The aim of this work evaluate an iterative reconstruction (IR) algorithm that helps reduce patient while maintaining quality as quantified by point spread function...
"Delta-radiomics" investigates variations in quantitative image metrics over time and can yield important clinical information. We hypothesized that patients undergoing active radiation therapy (RT) for prostate cancer (PCa), there would exist observable variation the describe T2-weighted (T2W) intensity histogram surrounding organs at risk (OAR) time. investigated feasibility of acquisition subsequent analysis delta-radiomic profiles these regions interest (ROI) serial T2W magnetic...
Purpose Radiation therapy (RT) planning frequently utilizes contrast‐enhanced CT. However, dose calculations should not be performed on a CT because the patient will receive bolus during treatment. It is typical to acquire twice RT simulation: once before injection of and after. The registration between these datasets introduces errors. In this work, we investigate use virtual noncontrast images (VNC) derived from dual‐energy (DECT) eliminate precontrast error. Methods datasets, including...
The purpose of this work is to investigate the use low-energy monoenergetic decompositions obtained from dual-energy CT (DECT) enhance image contrast and detection radiation-induced changes textures in pancreatic cancer.
We describe an apparatus used to measure the electron-antineutrino angular correlation coefficient in free neutron decay. The employs a novel measurement technique which is converted into proton time-of-flight asymmetry that counted directly, avoiding need for spectroscopy. Details of method, apparatus, detectors, data acquisition, and reduction scheme are presented, along with discussion important systematic effects.
Abstract Purpose . Precise identification of pancreatic tumors is challenging for radiotherapy planning due to the tumor's anatomical variability and poor visualization on 3D cross-sectional imaging. Low extracellular volume fraction (ECVf) correlates with vasculature uptake possible necrosis or hypoxia in tumors. This work investigates feasibility delineating using ECVf spatial distribution maps derived from contrast enhanced dual-energy CT (DECT). Methods Materials Data acquired simulation...
Adaptive radiation therapy (ART) is moving into the clinic rapidly. Capability of delineating tumor change as a result treatment response during delivery essential for ART. During image-guided (IGRT), CT or cone-beam taken at time daily setup and not visible by eye in regions soft tissue due to low contrast. The scope this paper develop method using classifier trained on non-contrast textures, estimate gross volume (GTV) day (GTVd) from (longitudinal) CTs acquired course IGRT when visible.CT...
Purpose: Substantial target motion during the delivery of radiation therapy (RT) for pancreatic cancer is well recognized as a major limiting factor on RT effectiveness. The aim this work to monitor intra‐fractional pancreas using ultrasound delivery. Methods: Transabdominal Ultrasound B‐mode images were collected from 5 volunteers research version Clarity Autoscan System (Elekta). autoscan transducer with center frequency MHz was utilized scans. Imaging parameters adjusted acquire at...
Purpose: It has been reported recently that the change of CT number (CTN) during and after radiation therapy (RT) may be used to assess RT response. The purpose this work is develop a tool automatically segment regions with differentiating CTN and/or in series CTs. Methods: A software was developed identify using K‐mean Cluster numbers delineate these convex hull enclosing method. Pre‐ Post‐RT CT, PET, or MRI images acquired for sample lung pancreatic cancer cases were test tool. cluster...
Purpose: Iterative reconstruction (IR) algorithms are developed to improve CT image quality (IQ) by reducing noise without diminishing spatial resolution or contrast. For in radiation therapy (RT), slightly increasing imaging dose IQ may be justified if it can substantially enhance structure delineation. The purpose of this study is investigate and quantify the enhancement as a result doses using IR algorithms. Methods: images were acquired for phantoms, built evaluate metrics including...
Purpose: It is desirable to increase CT soft-tissue contrast improve delineation of tumor target and/or surrounding organs at risk (OAR) in RT planning and delivery guidance. The purpose this work investigate the use monoenergetic decompositions obtained from dual energy (DE) contrast. Methods: data were acquired for 5 prostate pancreas patients a phantom with Scanner (Definition AS Open, Siemens) using both sequential DE protocols standard protocols. For protocols, scanner rapidly performs...
Purpose: Iterative reconstruction (IR) algorithms are developed to improve CT image quality (IQ) by reducing noise without diminishing spatial resolution or contrast. The IQ for patients with a high Body Mass Index (BMI) can suffer from increased due photon starvation. purpose of this study is investigate and quantify the enhancement BMI through application IR algorithms. Methods: raw data collected 6 radiotherapy (RT) BMI, greater than equal 30 were retrospectively analyzed. All acquired...