A5085123024- Dermatologic Treatments and Research
- Osteoarthritis Treatment and Mechanisms
- Laser Design and Applications
- Adipose Tissue and Metabolism
- Genetic and rare skin diseases.
- Peroxisome Proliferator-Activated Receptors
- Laser Applications in Dentistry and Medicine
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Vascular Malformations and Hemangiomas
- Solid State Laser Technologies
- Neuroinflammation and Neurodegeneration Mechanisms
- melanin and skin pigmentation
- Biochemical Analysis and Sensing Techniques
- Vascular Tumors and Angiosarcomas
- Epigenetics and DNA Methylation
- Cutaneous Melanoma Detection and Management
- Photodynamic Therapy Research Studies
- Receptor Mechanisms and Signaling
- Nonmelanoma Skin Cancer Studies
- Ocular and Laser Science Research
- Acne and Rosacea Treatments and Effects
- Optical Coherence Tomography Applications
- Neurogenesis and neuroplasticity mechanisms
- Bone fractures and treatments
Texas Tech University
2019-2024
Texas Tech University Health Sciences Center
2019-2024
P.N. Lebedev Physical Institute of the Russian Academy of Sciences
2004-2024
Federal Medical-Biological Agency
2024
Research Centre of Medical Technology and Biotechnology
2012-2021
The University of Texas at Austin
2007-2018
Karlsruhe Institute of Technology
2013
Institute of Neurobiology
2006
Institut de Biologie Moléculaire et Cellulaire
2006
Oregon Health & Science University
1999-2004
Alcohol abuse causes widespread changes in gene expression human brain, some of which contribute to alcohol dependence. Previous microarray studies identified individual genes as candidates for phenotypes, but efforts generate an integrated view molecular and cellular underlying addiction are lacking. Here, we applied a novel systems approach transcriptome profiling postmortem brains generated systemic brain alterations associated with abuse. We critical components previously unrecognized...
ABSTRACT Analysis of mouse brain gene expression, using strains that differ in alcohol consumption, provided a number novel candidate genes potentially regulate consumption. We selected six [beta‐2‐microglobulin ( B2m ), cathepsin S Ctss F Ctsf interleukin 1 receptor antagonist Il1rn CD14 molecule Cd14 ) and 6 Il6 )] for behavioral validation null mutant mice. These are known to be important immune responses but were not specifically linked consumption by previous research. Null mice tested...
In previous studies of memory span, participants have attended to the stimuli while they were presented, and therefore had opportunity use a variety mnemonic strategies. main portion present study, (first‐ fourth‐grade children, adults; 24 per age group) carried out visual task hearing lists spoken digits received post‐list digit recall cue only occasionally, for some lists. Under these conditions, list information presumably must be extracted from passively held store such as auditory...
Alcohol addiction develops through a series of stages, and mechanistic studies are needed to understand the transition from initial drug use sustained controlled alcohol consumption followed by abuse physical dependence. The focus this study was examine effects voluntary on brain gene expression profiles using mouse model binge drinking. main goal identify alcohol-responsive genes functional categories after single episode drinking intoxication.We used modification "Drinking In Dark" (DID)...
Chronically available alcohol escalates drinking in mice and a single injection of the immune activator lipopolysaccharide can mimic this effect result persistent increase consumption. We hypothesized that chronic injections will produce some similar molecular changes play role regulation intake. investigated mechanisms consumption or insult by gene expression profiling prefrontal cortex liver C57BL/6J mice. identified patterns transcriptional among four groups animals, three consuming (vs...
BackgroundAlcohol dependence and associated cognitive impairments apparently result from neuroadaptations to chronic alcohol consumption involving changes in expression of multiple genes. Here we investigated whether transcription factors Nuclear Factor-kappaB (NF-κB) family, controlling neuronal plasticity neurodegeneration, are involved these adaptations human alcoholics.Methods FindingsAnalysis DNA-binding NF-κB (p65/p50 heterodimer) the p50 homodimer as well proteins mRNAs was performed...
C57BL/6 inbred mice have been widely used as research models; however, widespread demand has led to the creation of several B6 substrains with markedly different phenotypes. In this study, we report that two mice, C57BL/6J (B6J) and C57BL/6NCrl (B6C), separated over 50 years ago at breeding facilities differ significantly in alcohol consumption preference. The genomes these are estimated by only 1–2% all gene loci, providing a unique opportunity extract particular expression signatures...
Cocaine and alcohol are two substances of abuse that prominently affect the central nervous system (CNS). Repeated exposure to cocaine leads longstanding changes in gene expression, subsequent functional CNS plasticity, throughout multiple brain regions. Epigenetic modifications histones one proposed mechanism guiding these enduring transcriptome. Characterizing large number available biological relationships as network models can reveal unexpected biochemical relationships. Clustering...
Alcohol use disorder (AUD) is a complex psychiatric with strong genetic and environmental risk factors. We studied the molecular perturbations underlying risky drinking behavior by measuring transcriptome changes across neurocircuitry of addiction in mouse model binge drinking. Sixteen generations selective breeding for high blood alcohol levels after session produced global brain gene expression alcohol-naïve High Drinking Dark (HDID-1) mice. Using profiles to generate circuit-level...
Loss of righting reflex (LRR) has traditionally been used to estimate hypnotic sensitivity ethanol in rodents. Traditional methods monitoring ethanol-induced sedation seems lack accuracy estimating blood concentration (BEC) at initial LRR, a measure sensitivity. Herein, we present novel method that improves detection the onset LRR by using new apparatus and loss-of-function criterion 5 s. DBA/2J C57BL/6J mice were placed cylindrical restrainers after injection 3 g/kg (20% v/v) ethanol....
Abstract Porous scaffold materials that can provide a framework for the cells to adhere, proliferate, and create extracellular matrix are considered be suitable bone regeneration. Interconnected porous chitosan scaffolds were prepared by freeze‐drying method, mineralized calcium phosphate solution double‐diffusion method form nanoapatite in matrix. The contains hydroxyapatite nanocrystals on surface also within pore channels of scaffold. To assess effect apatite porosity cells, human...
GABA A receptors mediate the majority of inhibitory neurotransmission in CNS. Genetic deletion α1 subunit results a loss α1-mediated fast currents and marked reduction density receptors. grossly normal phenotype α1-deficient mice suggests presence neuronal adaptation to these drastic changes at synapse. We used cDNA microarrays identify transcriptional fingerprints cellular plasticity response altered GABAergic inhibition cerebral cortex cerebellum mutants. In silico analysis 982...
Chronic pain presents a therapeutic challenge due to the highly complex interplay of sensory, emotional-affective and cognitive factors. The mechanisms transition from acute chronic are not well understood. We hypothesized that neuroimmune in amygdala, brain region involved component modulation, play an important role through high motility group box 1 (Hmgb1), pro-inflammatory molecule has been linked signaling spinal nociception. Transcriptomic analysis revealed upregulation Hmgb1 mRNA...
Fractures in horses-whether simple fractures with just one clean break, or incomplete greenstick stress fractures, complications such as shattered bones can all be either minimal even catastrophic. Thus, improvement fracture healing is a hallmark equine orthopedics. The process implements complex sequence of events including the initial inflammatory phase removing damaged tissue, re-establishment vessels and mesenchymal stromal cells, soft hard callus closing gap well remodeling shaping bone...