A5037587153- Oil Palm Production and Sustainability
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Biofuel production and bioconversion
- Genetic Neurodegenerative Diseases
- Cocoa and Sweet Potato Agronomy
- Coconut Research and Applications
- Cancer-related gene regulation
- Mitochondrial Function and Pathology
- Genomics and Chromatin Dynamics
- Lipid metabolism and biosynthesis
- Chromosomal and Genetic Variations
- Metabolism and Genetic Disorders
- Genetic diversity and population structure
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Forest ecology and management
- Genetic Syndromes and Imprinting
- Peptidase Inhibition and Analysis
- Genetic and phenotypic traits in livestock
- Neurological disorders and treatments
- Biodiesel Production and Applications
- Plant and animal studies
- Ubiquitin and proteasome pathways
Orion Genomics (United States)
2007-2024
St. Jude Children's Research Hospital
2002-2004
University of Alabama at Birmingham
1996-2003
Lexicon Pharmaceuticals (United States)
2003
The genome sequence of the African oil palm, main source production, is used to predict at least 34,802 genes, including biosynthesis genes; comparison with draft South American palm reveals that two species may have diverged in New World and segmental duplications chromosome arms define palaeotetraploid origin trees. Two papers published this issue Nature deal genetics variants one most important crops use today — Elaeis guineensis its cousin oleifera. Palm accounts for almost half edible...
Oil palm, a plantation crop of major economic importance in Southeast Asia, is the predominant source edible oil worldwide. We report identification VIRESCENS (VIR) gene, which controls fruit exocarp colour and an indicator ripeness. VIR R2R3-MYB transcription factor with homology to Lilium LhMYB12 similarity Arabidopsis PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP1). identify five independent mutant alleles over 400 accessions from sub-Saharan Africa that account for dominant-negative virescens...
Cytosine-methylation changes are stable and thought to be among the earliest events in tumorigenesis. Theoretically, DNA carrying tumor-specifying methylation patterns escape tumors may found circulating sera from cancer patients, thus providing basis for development of noninvasive clinical tests early detection. Indeed, using methylation-specific PCR-based techniques, several groups reported detection tumor-associated methylated patients with varying success. However, by design, such...
Recent data have revealed that epigenetic alterations, including DNA methylation and chromatin structure changes, are among the earliest molecular abnormalities to occur during tumorigenesis. The inherent thermodynamic stability of cytosine apparent high specificity alterations for disease may accelerate development powerful diagnostics cancer. We report a genome-wide analysis in breast approach efficiently identified large collection novel differentially methylated loci (∼200), subset which...
Using a unique microarray platform for cytosine methylation profiling, the DNA landscape of human genome was monitored at more than 21 000 sites, including 79% annotated transcriptional start sites (TSS). Analysis an oligodendroglioma derived cell line LN-18 revealed 4000 methylated TSS. The gene-centric analysis indicated complex pattern exists along each autosome, with trend increasing density approaching telomeres. Remarkably, 2% CpG islands (CGI) were densely methylated, and 17% had...
Oil palm (Elaeis guineensis) is the most productive oil bearing crop worldwide. It has three fruit forms, namely dura (thick-shelled), pisifera (shell-less) and tenera (thin-shelled), which are controlled by SHELL gene. The forms exhibit monogenic co-dominant inheritance, where a hybrid obtained crossing maternal paternal palms. Commercial production based on planting thin-shelled palms, typically yield 30% more than while palms female-sterile have little to no yield. clear that hybrids...
Aberrant gene silencing of genes through cytosine methylation has been demonstrated during the development many types cancers including prostate cancer. Several GSTP1 have shown to be methylated in cancer leading suggestion and demonstration that status such could used as diagnosis markers alone or support histology. We developed a bisulfite-free alternative, MethylScreen technology, an assay for DNA detection utilizing combined restriction from both methylation-sensitive enzymes (MSRE)...
Abstract Acacia crassicarpa is an important tree species in Southeast Asia, where hundreds of thousands hectares planted forests are supported by advancements silviculture and genetic improvement. Although possible, controlled pollination impractical for advancing breeding populations, requiring unreasonable effort to produce more than a few crosses per year. For this reason, populations often bred open pollination. This study used large-scale pedigree reconstruction multi-environment trials...
Ref-1 participates in DNA repair as well redox regulation of transcription factor function. The function involves reduction oxidized cysteine residues within the binding domains several factors, including Fos and Jun. Reduction these is required for binding, providing a redox-dependent mechanism target gene expression. Previous vitro studies implicated 65 human (cysteine 64 mouse Ref-1) catalytic site. We analyzed vivo role AP-1 activity by introducing cysteine-to-alanine point mutation into...
Elaeis guineensis and E. oleifera are the two species of oil palm. is most widely cultivated commercial species, introgression desirable traits from ongoing. We report an improved genome assembly with substantially increased continuity completeness, as well first chromosome-scale assembly. Each was obtained by integration long-read sequencing, proximity ligation optical mapping, genetic mapping. High interspecific conservation observed between species. The study provides extensive gene...
Abstract DNA methylation (DNAm) is a term used to describe the heritable covalent addition of methyl group cytosines at CpG dinucleotides in mammals. While methods for examining DNAm status specific loci have existed several years, recent technological advances begun enable examination across genome. In this unit, we comprehensive high‐throughput arrays relative (CHARM), highly sensitive and approach measure This method makes no assumptions about where functionally important occurs, i.e.,...
Oil palm breeding involves crossing dura and pisifera palms to produce tenera progeny with greatly improved oil yield. yield is controlled by variant alleles of a type II MADS-box gene, SHELL, that impact the presence thickness endocarp, or shell, surrounding fruit kernel. We identified six novel SHELL in noncommercial African germplasm populations from Malaysian Palm Board. These provide extensive diversity harness genetic, mechanistic phenotypic variation associated globally critical crop....
Abstract Background The c- fos gene was originally identified as the cellular homolog of oncogene v- carried by Finkel-Biskis-Jenkins and Finkel-Biskis-Reilly murine osteogenic sarcoma retroviruses. Sustained expression is sufficient to induce transformation in vitro tumorigenesis vivo . Fos functions a component AP-1 transcription factor complex regulate several differentially expressed genes have been cells transformed We extended these studies constructing system for conditional Using...
Abstract We reported previously a model of polyglutamine repeat disorders with insertion 146 CAG repeats into the murine hypoxanthine phosphoribosyl transferase locus (Hprt (CAG)146 ; Ordway et al. [ 1997 ] Cell 91:753–763), which does not normally contain repeats. These mice develop an adult‐onset neurologic phenotype incoordination, involuntary limb clasping, seizures, and premature death. Histologic analysis demonstrates widespread ubiquinated neuronal intranuclear inclusions (NIIs). now...
The oil palm is the most productive bearing crop that an important source of edible oil. As land resources become more limited, sustainable growth needed to increase productivity on existing agricultural meet needs growing populations. Nevertheless, genetic improvement through conventional breeding extremely slow and costly. Revolutionary approaches are improve address stagnating average yields observed over last three decades. In 2013, impetus this "green " revolution came with successful...