A5018735122- Pharmaceutical and Antibiotic Environmental Impacts
- Analytical chemistry methods development
- Medicinal Plants and Neuroprotection
- Exercise and Physiological Responses
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Mangiferin and Mango Extracts
- Botany, Ecology, and Taxonomy Studies
- Environmental Chemistry and Analysis
- Diagnosis and treatment of tuberculosis
- Water Quality Monitoring and Analysis
- Tuberculosis Research and Epidemiology
- Pomegranate: compositions and health benefits
- Pharmacological Effects and Assays
- Ginger and Zingiberaceae research
- Mass Spectrometry Techniques and Applications
- Plant Virus Research Studies
- Analytical Chemistry and Chromatography
- Coenzyme Q10 studies and effects
- Pesticide Residue Analysis and Safety
- Adipose Tissue and Metabolism
- Psidium guajava Extracts and Applications
- Adrenal Hormones and Disorders
- Vitamin C and Antioxidants Research
- Medicinal Plants and Bioactive Compounds
Universidad de Las Palmas de Gran Canaria
2009-2025
The natural polyphenols mangiferin and luteolin have free radical-scavenging properties, induce the antioxidant gene program down-regulate expression of superoxide-producing enzymes. However, effects these two on exercise capacity remains mostly unknown. To determine whether a combination (peanut husk extract containing 95% luteolin, PHE) (mango leave (MLE), Zynamite®) at low (PHE: 50 mg/day; 140 mg/day MLE 100 mg mangiferin; L) high doses MLE: 420 H) may enhance performance, twelve...
Mangiferin, a glucosyl xanthone, is plant metabolite with promising nootropic and ergogenic properties. However, its poor inconsistent systemic bioavailability limits therapeutic potential. Additionally, the pharmacokinetics of mangiferin from mango leaf extract formulations remain uncharacterized in humans. This study validated UHPLC-MS/MS method conducted human pharmacokinetic approved by an ethics committee. The monosodium salt was assessed two standardized extracts: MLE60, to 60% but...
Background and aims:Aframomum melegueta (A. melegueta) from the ginger family is appreciated for its pungent seeds widely used in African ethno-medicine. Among several biological activities associated with seed's preparations, some preclinical studies suggest a set of neuroactive properties that have not been tested humans to date. We performed clinical trial investigate effects A. seed extracts on anxiety, stress, mood, sleep healthy subjects moderate anxiety levels. In vitro...
Background/Objectives: A mango (Mangifera indica) leaf extract (Zynamite®), rich in the polyphenol mangiferin, has been demonstrated to modulate brain activity, boost cognitive function, and reduce mental fatigue. Research evidence supports that improving solubility of this could significantly enhance its efficacy as an active ingredient. This study examined effects a soluble version Zynamite®, Zynamite® S (Zyn-S), on function mood young adults at low doses. Methods: total 119 university...
Liquid and solid samples from two wastewater treatment plants (WWTPs) on Gran Canaria Island (Spain) have been tested for the presence of compounds with endocrine-disrupting properties. The selected degradation stages were sampled bimonthly each WWTP over 12-month period July 2010 to 2011. analytical methods used determination (EDCs) based on-line phase extraction, microwave-assisted extraction (MAE), ultrasonic-assisted (UAE) coupled UHPLC-MS/MS. All hyphenated methodologies employed in...
Background: Health system delay (HSD) is an important issue in tuberculosis (TB) control. This report investigates HSD and associated factors a cohort of Spanish culture-confirmed TB patients. Methods: Data were collected from clinical records. Using logistic regression with two different cut-off points to define (median 75th percentile), adjusted odds ratios used estimate the association between variables. Results: A total 5184 cases included. Median percentile 6 25 days respectively....
Leaves of Mangifera indica L. have folk-uses in tropical regions the world as health teas, a remedy for exhaustion and fatigue, vegetable, medicine. leaf extract (MLE) had previously been demonstrated to alter brain electrical activity in-vivo. The aim present series studies was investigate whether mangiferin, major compound leaves MLE, is responsible neurocognitive if CNS activities MLE translational potential.MLE, tradename Zynamite, produced by Nektium Pharma, Spain. Isolated mangiferin...
The analytical performances and applications of various luminescence spectrometric methods to the study determination pollutants present at low levels in environment are reviewed for last two decades (1990 – 2010). first part concerns stationary systems, including fluorescence, photochemically-induced phosphorescence related methods. In second part, combination these with flow techniques such as high performance liquid chromatography (HPLC), capillary electrophoresis (CE) injection analysis...
The mango leaf extract rich in mangiferin Zynamite® improves exercise performance when combined with luteolin or quercetin ingested at least 48 h prior to exercise. To determine whether a single dose of administered 1 before increases repeated-sprint performance, 20 men and women who were physically active randomly assigned three treatments following double-blind cross-over counterbalanced design. Treatment A, 140 mg Zynamite®, quercetin, 147.7 maltodextrin, 420 sunflower lecithin; B, 2126...
Zynamite PX®, a mango leaf extract combined with quercetin, enhances exercise performance by unknown molecular mechanisms. Twenty-five volunteers were assigned to control (17 males) or supplementation group (8 males, receiving 140 mg of Zynamite® + quercetin/8 h for 2 days). Then, they performed incremental exhaustion (IE) followed occlusion the circulation in one leg 60 s. Afterwards, cuff was released, and 30 s sprint performed, 90 circulatory (same leg). Vastus lateralis muscle biopsies...
Biomarkers, 25-hydroxyvitamin D3 and D2 , are important indicators of the vitamin D general status monitored in several pathophysiological disorders, such as osteoporosis, diabetes, heart disease, etc. A novel ultra-HPLC with MS/MS methodology for analysis derivatives coupled a very simple highly rapid sample preparation step was developed. Analytical parameters obtained showed linearity (R(2) ) above 0.999 both vitamins accuracies between 95.8 102%. The LODs were low 0.22 0.67 nmol/L...
Xanthigen® is a nutraceutical combination for weight management capable of increasing energy expenditure via uncoupling protein 1 (UCP-1) in white adipose tissue. It consists brown seaweed Undaria pinnatifida extract, rich the carotenoid fucoxanthin (FX) and pomegranate seed oil (PSO), punicic acid. Xanthigen was screened to determine its genotoxicity 90-days repeated oral toxicity. Genotoxicity assessed with Ames test (TA89, TA100, TA1535, TA1537, WP2), chromosomal aberration assay (Chinese...
Background This study was designed to evaluate the beneficial effects of a botanical extract combination containing soy isoflavone (100mg), Aframomum melegueta seed dry (50 mg), and Punica granatum skin (100mg) on health-related Quality Life in healthy Spanish menopausal women with hot flashes, anxiety, depressive symptoms using validated Cervantes Scale. Methods results Fifty-seven outpatient (45–65 years) menstrual problems associated climacteric syndrome were enrolled from April 2018 2019...
To find possible therapeutic applications involving the Central Nervous System (CNS) for herbals is a major challenge during functional food and drug discovery development programmes. Despite availability of numerous in vitro vivo tests, there no single agreed screening procedure pharmacological testing herbal extracts with anticipated CNS activity. Experience gained from more than 25 years has shown that two models give reasonably reliable orientation future applications: construction an...