Background and aims:Aframomum melegueta (A. melegueta) from the ginger family is appreciated for its pungent seeds widely used in African ethno-medicine. Among several biological activities associated with seed's preparations, some preclinical studies suggest a set of neuroactive properties that have not been tested humans to date. We performed clinical trial investigate effects A. seed extracts on anxiety, stress, mood, sleep healthy subjects moderate anxiety levels. In vitro...

Mangiferin, a glucosyl xanthone, is plant metabolite with promising nootropic and ergogenic properties. However, its poor inconsistent systemic bioavailability limits therapeutic potential. Additionally, the pharmacokinetics of mangiferin from mango leaf extract formulations remain uncharacterized in humans. This study validated UHPLC-MS/MS method conducted human pharmacokinetic approved by an ethics committee. The monosodium salt was assessed two standardized extracts: MLE60, to 60% but...

Background/Objectives: A mango (Mangifera indica) leaf extract (Zynamite®), rich in the polyphenol mangiferin, has been demonstrated to modulate brain activity, boost cognitive function, and reduce mental fatigue. Research evidence supports that improving solubility of this could significantly enhance its efficacy as an active ingredient. This study examined effects a soluble version Zynamite®, Zynamite® S (Zyn-S), on function mood young adults at low doses. Methods: total 119 university...

Urinary albumin excretion has been consistently found to be normal in a significant number of subjects with early stages diabetic kidney disease. This study was aimed estimate the prevalence and characteristics non-albuminuric chronic disease associated type 2 diabetes mellitus among who reach advanced renal failure. Study population composed incident patients (glomerular filtration rate <30 mL/min) related tertiary hospital from Gran Canaria (Spain) during period years. Subjects were...

It remains unknown whether polyphenols such as luteolin (Lut), mangiferin and quercetin (Q) have ergogenic effects during repeated all-out prolonged sprints. Here we tested the effect of Mangifera indica L. leaf extract (MLE) rich in (Zynamite®) administered with either tiger nut (TNE), or (Lut) on sprint performance recovery from ischemia-reperfusion. Thirty young volunteers were randomly assigned to three treatments 48 h before exercise. Treatment A: placebo (500 mg maltodextrin/day); B:...

Prolonged or unusual exercise may cause exercise-induced muscle damage (EIMD). To test whether Zynamite®, a mango leaf extract rich in the natural polyphenol mangiferin, administered combination with quercetin facilitates recovery after EIMD, 24 women and 33 men were randomly assigned to two treatment groups matched by sex 5 km running performance, ran 10 race followed 100 drop jumps elicit EIMD. One hour before competition, every 8 h thereafter for h, they ingested placebo (728 mg of...

To characterize the cardiovascular risk profile of subjects categorized differently by A1C- and oral glucose tolerance test (OGTT)-based diagnostic criteria for diabetes according to recommendations American Diabetes Association (ADA).An OGTT, A1C, several factors were assessed in 964 individuals without known participating a cross-sectional epidemiological survey Gran Canaria, Spain.Taking OGTT as gold standard, sensitivity specificity an A1C value ≥ 6.5% 38.7 99.6%, respectively. Subjects...

Vitamin D deficiency is highly prevalent in subjects with advanced chronic kidney disease (CKD), but diabetes, the most common cause of CKD, has also been linked to low levels serum 25-hydroxyvitamin [25(OH)D]. We compare vitamin status between type 2 diabetes-related CKD and either without diabetes or CKD.Subjects were patients (estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2) from February 2011 November 2013 (113 80 diabetes) 61 long-lasting simultaneously enrolled our...

Leaves of Mangifera indica L. have folk-uses in tropical regions the world as health teas, a remedy for exhaustion and fatigue, vegetable, medicine. leaf extract (MLE) had previously been demonstrated to alter brain electrical activity in-vivo. The aim present series studies was investigate whether mangiferin, major compound leaves MLE, is responsible neurocognitive if CNS activities MLE translational potential.MLE, tradename Zynamite, produced by Nektium Pharma, Spain. Isolated mangiferin...

Background Portable blood glucose meters ( PBGM s) allow easy measurements. As animal‐specific s are not available everywhere, those for humans widely used. Objectives To assess the accuracy and precision of 9 in canine whole WB ) plasma, based on ISO 15197:2013. Animals Fifty‐nine client‐owned dogs attending Veterinary Teaching Hospital. Methods Analytical evaluation 100 samples was performed 23 (glucose 29–579 mg/dL) following recommendations. A considered accurate if 95% measurements were...

Background and Aim Diabetic dyslipidaemia is common in type 2 diabetes (T2D) insulin resistance often precedes the onset of T2D. The Taq1B polymorphism CETP (B1 B2 alleles) (rs708272) G-250A LIPC (rs2070895) are associated with changes enzyme activity lipid concentrations. Our aim was to assess effects both polymorphisms on risk Methods Results In a case-control study from population-based Telde cohort, were analysed by PCR-based methods. Subjects classified, according an oral glucose...

&lt;i&gt;Background:&lt;/i&gt; This study aimed to examine the changes in serum lipids children with mild hypercholesterolemia after use of skim milk or olive-oil-enriched their diet and modulation lipid levels by Taq 1B polymorphism cholesteryl-ester transfer protein gene. &lt;i&gt;Methods:&lt;/i&gt; Thirty-six prepubertal were randomly assigned a crossover design into 2 groups 16 20 individuals. Both received, sequential inverse order, types for periods 6 weeks. &lt;i&gt;Results:&lt;/i&gt;...

Zynamite PX®, a mango leaf extract combined with quercetin, enhances exercise performance by unknown molecular mechanisms. Twenty-five volunteers were assigned to control (17 males) or supplementation group (8 males, receiving 140 mg of Zynamite® + quercetin/8 h for 2 days). Then, they performed incremental exhaustion (IE) followed occlusion the circulation in one leg 60 s. Afterwards, cuff was released, and 30 s sprint performed, 90 circulatory (same leg). Vastus lateralis muscle biopsies...

Xanthigen® is a nutraceutical combination for weight management capable of increasing energy expenditure via uncoupling protein 1 (UCP-1) in white adipose tissue. It consists brown seaweed Undaria pinnatifida extract, rich the carotenoid fucoxanthin (FX) and pomegranate seed oil (PSO), punicic acid. Xanthigen was screened to determine its genotoxicity 90-days repeated oral toxicity. Genotoxicity assessed with Ames test (TA89, TA100, TA1535, TA1537, WP2), chromosomal aberration assay (Chinese...

Purpose: The purpose of this study was to develop, build, and implement a virtual platform equipped with practical tools, relevant contents, communication rooms, the aim facilitating patients’ self-management type 1 diabetes mellitus (T1DM). Materials methods: design based on suggestions T1DM patients who were being managed at two reference hospitals. Patients’ needs preferences identified in group discussion sessions. Before having access platform, underwent baseline assessment, which...

Background The relationship between the metabolic syndrome and mild chronic kidney disease (CKD) has been extensively studied. This study was aimed to estimate prevalence factors associated with among subjects advanced stages of nondiabetes-related CKD. Methods Study population composed incident patients CKD not related diabetes in a tertiary hospital from Gran Canaria (Spain) since February 2011 December 2014. Participants fulfilled survey questionnaire underwent physical examination...

Background This study was designed to evaluate the beneficial effects of a botanical extract combination containing soy isoflavone (100mg), Aframomum melegueta seed dry (50 mg), and Punica granatum skin (100mg) on health-related Quality Life in healthy Spanish menopausal women with hot flashes, anxiety, depressive symptoms using validated Cervantes Scale. Methods results Fifty-seven outpatient (45–65 years) menstrual problems associated climacteric syndrome were enrolled from April 2018 2019...

Coronary artery disease (CAD) has turned into a prevalent cause of morbi-mortality contributing some polymorphisms in the recurrence major adverse cardiac events (MACE).Three hundred and fifty six patients with first myocardial infarction (MI) were followed up during 60-month period to find out if ACE I/D, AT1R A1166C, PAI-I 4G/5G GPIIIa a1/a2 polymorphisms, combination other classical cardiovascular risk factors, can contribute relapse MACE.Two eighty five (80.1%) men 71 (19.9%) women after...

Preclinical studies and small clinical trials suggest that glucagon-like peptide 1 (GLP1) may have a positive effect on ventricular function. Liraglutide is GLP1-analogue used in the treatment of type 2 diabetes. LIPER2 phase IV, randomised, double-blind, placebo-controlled, parallel-design trial, assessing 6 months' liraglutide 1.8 mg/d measures cardiac function physical performance patients with A total 30 diabetes will be included, if their HbA1c between 7 10% while oral agents (including...

This study analyses discordance rates between attainment of therapeutic goals for apolipoprotein B100 (apoB) and both low-density lipoprotein–cholesterol (LDL-C) non-high-density (non-HDL-C) in a sample 152 patients with type 2 diabetes chronic kidney disease from Gran Canaria (Spain), using treatment targets recommended by the American Diabetes Association/American College Cardiology (ADA/ACC), European Society Cardiology/European Atherosclerosis (ESC/EAS) Spanish population-based study....