A5030180925- Ovarian function and disorders
- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Ovarian cancer diagnosis and treatment
- Lipid metabolism and disorders
- Reproductive System and Pregnancy
- Genetic Associations and Epidemiology
- Prenatal Screening and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Hormonal and reproductive studies
- Assisted Reproductive Technology and Twin Pregnancy
- Glutathione Transferases and Polymorphisms
- Peroxisome Proliferator-Activated Receptors
- Gestational Diabetes Research and Management
- Uterine Myomas and Treatments
- Ectopic Pregnancy Diagnosis and Management
- Genetic Syndromes and Imprinting
- Parvovirus B19 Infection Studies
- Menstrual Health and Disorders
- Rabies epidemiology and control
- Maternal and Neonatal Healthcare
- Liver Disease Diagnosis and Treatment
- Escherichia coli research studies
- Microbial infections and disease research
- Vitamin D Research Studies
Dongguk University Ilsan Hospital
2008-2022
Maria Fertility Hospital
2010-2021
Seoul National University
2007-2010
Seoul National University Bundang Hospital
2008
CHA Gangnam Medical Center
2008
Seoul National University Hospital
2008
Boramae Medical Center
2008
We investigated the differences in anthropometrical, hormonal and insulin resistance parameters according to subtype of polycystic ovary syndrome (PCOS) Korean women. recruited 166 women with PCOS retrospectively 277 controls. was diagnosed by irregular menstruation (IM), (PCO) hyperandrogenism (HA). Subjects were divided into four subgroups: IM/HA/PCO group (n = 87, 52.4%), IM/PCO 52, 31.3%), IM/HA 23, 13.9%) HA/PCO 4, 2.4%). Clinical biochemical variables compared among subgroups. The...
The objectives of this study were to define the distribution modified Ferriman-Gallwey (mF-G) score in a random group Korean women and any association(s) between hirsutism endocrine/metabolic markers.A single investigator assessed mF-G prospectively 1010 women, who consulted health-care center as part check-up for employment. Logistic regression models utilized test relationships presence levels markers.Subjects had scores ranging from 0 19, 505 subjects (50.0%) an zero. Of subjects, 95.1%...
TO INVESTIGATE: the prevalence of vitamin D deficiency in Korean women with polycystic ovary syndrome (PCOS), and relationship between status clinical or metabolic features this group.We recruited 38 PCOS using Rotterdam criteria. A total 109 premenopausal control were matched patients based on age body mass index. Serum 25-hydroxy concentrations less than 20 ng/mL classified as frank deficiency. Since may play a significant role disturbances PCOS, correlations parameters analyzed separately...
Background Hyperandrogenism (HA) has been linked with several components of metabolic syndrome (MetS). Few studies in Asian women have evaluated the important risk factors for and prevalence MetS according to PCOS subtype. In this study, we investigated differences parameters two major phenotypic subgroups Korea. Furthermore, relationship between HA-associated MetS. Materials Methods This cross-sectional observational study was conducted from May 2010 December 2011 A total 837 females PCOS,...
Insulin resistance is a core feature of polycystic ovary syndrome (PCOS). Recently, genome-wide association studies have reported number single-nucleotide polymorphisms (SNPs) with reproducible associations and susceptibilities to type 2 diabetes. We examined the potential between diabetogenic genes uncovered in PCOS Korean women.Case-control study.Women or without PCOS.DNA samples from 377 patients 386 age-matched controls were genotyped.None 12 SNPs six (KCNJ11, TCF7L2, SLC30A8, HHEX, FTO...
Abstract STUDY QUESTION What is the impact of newly recommended antral follicle count (AFC) cutoff for polycystic ovary (PCO) on diagnostic status syndrome (PCOS)? SUMMARY ANSWER Among patients with phenotypes requiring presence PCO diagnosis, approximately half (48.2%) were excluded from having PCOS based new AFC cutoff, although these women had worse metabolic and hormonal profiles than controls indistinguishable remaining regard to major parameters. WHAT IS KNOWN ALREADY In Rotterdam...
The purpose of the current study was to compare circulating levels visfatin between women with polycystic ovary syndrome (PCOS) and those without PCOS assess correlations various parameters. This case-control recruited 74 patients age- body mass index (BMI)-matched controls. Serum were evaluated using enzyme-linked immunosorbent assay. Women divided into 2 subgroups based on presence clinical or biochemical hyperandrogenism. possible differences in serum hyperandrogenic non-hyperandrogenic...
Recently, the American Diabetes Association (ADA) has included glycated hemoglobin A1c (A1C) level as a component of diagnostic criteria ‘diabetes’ or ‘increased risk for diabetes’. This study was conducted to examine prevalence and factors ‘elevated A1C’ (≥5.7%) in women with polycystic ovary syndrome (PCOS). A1C measured using an immunoturbidimetric assay, evaluated 154 patients PCOS 469 age-matched controls (match ratio 1–3). All subjects were categorized by BMI (non-obese <25 kg/m2 obese...
STUDY QUESTIONIs a preponderance of small dense low-density lipoprotein-cholesterol (LDL-C) observed in non-obese women with polycystic ovary syndrome (PCOS)?
ObjectiveTo investigate whether specific genetic polymorphisms in the cyclin-dependent kinase inhibitor 2B antisense RNA (CDKN2B-AS) gene and near wingless-type MMTV integration site family member 4 (WNT4) are associated with endometriosis a Korean population.DesignCase-control association study.SettingUniversity.Patient(s)Surgically or histologically diagnosed cases of (n = 673) controls 500) among population ethnic Koreans.Intervention(s)None.Main Outcome Measure(s)Genotype distribution...
Problem The aim of this study was to investigate the relationship between polymorphisms tumor necrosis factor‐α (TNF‐α) and TNF receptor (TNFR) genes serum levels TNF‐α its soluble (sTNFR) in Korean women with endometriosis. Method C(−857)T, C(−863)A T(−1031)C, TNFR1 A(36)G, TNFR2 T(676)G, A(1663)G, T(1668)G C(1690)T polymorphisms, TNF‐α, sTNFR1, sTNFR2 were analyzed ( n = 105) without endometriosis 101). Results Serum sTNFR1 significantly higher than those endometriosis, whereas no...
The aim of this study was to investigate the effect insulin sensitizing agents on hormonal and metabolic parameters as well menstrual patterns in women with polycystic ovary syndrome (PCOS).One hundred twenty-three patients PCOS were included. Metformin administered at 1,500 mg or 1,700 daily for 3 months. If had no improvement cycle metformin-related adverse effects developed, changed medication a dose either 15 pioglitazone up 45 mg. Then resumption regular recovery ovulation evaluated....
Objective Metabolic disturbances are well-recognized clinical features of polycystic ovary syndrome (PCOS). Carotid intima-media thickness (CIMT) has been widely used as a surrogate marker atherosclerosis and cardiovascular disease (CVD). CIMT in women with PCOS investigated many studies, but there only one report the Korean population. The aim present study was to compare presence subclinical young untreated age-matched controls, specifically by measuring their CIMT. Methods measured...
<i>Background/Aims:</i> To investigate whether the peroxisome proliferator-activated receptor-γ <i>(PPAR-</i>γ<i>)</i> Pro12Ala and PPAR-γ coactivator-1α <i>(PGC-1</i>α<i>)</i> Gly482Ser polymorphisms were associated with polycystic ovary syndrome (PCOS). <i>Methods:</i> Genetic analyses of <i>PPAR-</i>γ <i>PGC-1</i>α performed in 184 patients PCOS 256 controls. Hormone levels, biochemical...
<i>Background/Aims:</i> The aim of this study was to investigate the possibility that K469E and G241R polymorphisms in intercellular adhesion molecule-1 (ICAM-1) gene C-634G polymorphism interleukin (IL)-6 are associated with endometriosis Korean population. <i>Methods:</i> ICAM-1 IL-6 were evaluated 390 patients 351 controls by polymerase chain reaction-restriction fragment length analysis. <i>Results:</i> not observed all subjects. No differences...
To investigate whether the peroxisome proliferator-activated receptor (PPAR)-γ2 Pro12Ala polymorphism is associated with a risk of advanced-stage endometriosis in Korean population. Case-control study collective 446 patients and 427 controls. The PPAR-γ2 gene was genotyped using polymerase chain reaction (PCR) restriction fragment length (RFLP) analysis.The distribution different between group control (non-CC rates were 5.2% for advanced 10.1% group, respectively, P = 0.006). frequency...
To investigate changes in glycaemic status women with polycystic ovary syndrome (PCOS).Longitudinal observational study.Women PCOS who underwent baseline and follow-up screening tests for diabetes (n = 262). Four patients type 2 (T2DM) at 6 were taking drugs the final excluded.Changes classification based on fasting glucose, haemoglobin A1c oral glucose tolerance test.The median length of was 2.9 years. The mean age body mass index normoglycaemia group 202) 23.0 years 21.6 kg/m2 , while it...
The objective of this study was to determine the effect vaccination against classical swine fever virus (CSFV) on development postweaning multisystemic wasting syndrome (PMWS) in conventional pigs infected experimentally with porcine circovirus type 2 (PCV-2). PCV-2 and immunised modified live CSFV developed mild moderate PMWS, whereas none alone or PMWS. Lesions histologically characteristic PMWS were observed lymph nodes from vaccine, extensive replication detected by situ hybridisation.