A5101501656- Head and Neck Cancer Studies
- Genetics and Neurodevelopmental Disorders
- Sarcoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Pain Mechanisms and Treatments
- Genetic factors in colorectal cancer
- Genomics and Rare Diseases
- Vascular Tumors and Angiosarcomas
- Nutrition, Genetics, and Disease
- Fatty Acid Research and Health
- Herbal Medicine Research Studies
- Growth Hormone and Insulin-like Growth Factors
- Platelet Disorders and Treatments
- Advanced Radiotherapy Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Asthma and respiratory diseases
- Lung Cancer Treatments and Mutations
- Dietary Effects on Health
- Plant Disease Resistance and Genetics
- Musculoskeletal pain and rehabilitation
- Genetic Syndromes and Imprinting
- Cytomegalovirus and herpesvirus research
- Plant-Microbe Interactions and Immunity
- Nutritional Studies and Diet
West China Second University Hospital of Sichuan University
2020-2025
Sichuan University
2020-2025
Huzhou University
2023
Hunan Cancer Hospital
2022
Northwest Women's and Children's Hospital
2020
Washington University in St. Louis
2018
Sleep and circadian phenotypes are associated with several diseases. The present study aimed to investigate whether sleep were causally linked coronavirus disease 2019 (COVID-19)-related outcomes.Habitual duration, insomnia, excessive daytime sleepiness, napping, chronotype selected as exposures. Key outcomes included positivity hospitalization for COVID-19. In the observation cohort study, multivariable risk ratios (RRs) their 95% confidence intervals (CIs) calculated. Two-sample Mendelian...
Whether regular fish oil supplementation is associated with cancer risk controversial. We aimed to evaluate the association of on according fatty consumption patterns. From UK Biobank cohort, 470 804 participants data were included. A total 147 316 individuals in exposed group; other 323 488 unexposed group. No was found between self-report and overall (hazard ratio [HR] = 0.97, 95% confidence intervals [CIs] 0.95-1). Stratified by level, we lower who consumed less than two times per week,...
Abstract Background Zhu‐Tokita‐Takenouchi‐Kim (ZTTK, OMIM# 617140) syndrome is a rare, autosomal dominant genetic disorder caused by heterozygous variants in the SON gene (OMIM#182465, GenBank#NC_000021.9). There are only 33 cases and 26 causative reported to date since first report 2015. Here, we new case of ZTTK de novo disease‐causing variant. Methods We conducted whole‐exome sequencing (WES) obtain data patient. The clinical patient were analyzed. Results features our strikingly similar...
This study investigated the association between body mass index (BMI) trajectories in late middle age and incident diabetes later years. A total of 11,441 participants aged 50-60 years from Health Retirement Study with at least 2 self-reported BMI records were included. Individual representing average changes per year generated using multilevel modeling. Adjusted risk ratios (ARRs) 95% confidence intervals (95% CIs) calculated. Associations different genetic risks estimated for 5,720...
Abstract Alport syndrome (AS) is one of the most common inherited kidney disorders, involving pathogenic variants COL4A3, COL4A4 and COL4A5 genes that lead to disruption normal structure collagen IV protein through improper chain or heterotrimer folding degradation components. Lipoprotein glomerulopathy (LPG) an autosomal dominant disease APOE gene mutations disturbing lipoprotein metabolism. We report first case with both AS LPG in 11‐year‐old girl. The patient presented blepharedema,...
Lesch-Nyhan disease (LND) is a rare X-linked recessive caused by pathogenic mutations of the HPRT1 gene. The typical clinical manifestations include cerebral palsy, intellectual disability, dysarthria, self-injurious behavior, and gouty arthritis in children. This report describes Chinese boy aged 2 months 7 days with significantly elevated uric acid concentration accompanied renal dysfunction and, notably, brain imaging changes. Whole-exome sequencing revealed hemizygous mutation nucleotide...
Evidence is limited on the risk impact of body pain future chronic disease. The present study aimed to investigate association between and diseases.Data were analyzed using four waves China Health Retirement Longitudinal Study with 17 708 individual respondents aged 45 years older. disease was estimated in both a cross-sectional cohort (2011) longitudinal (2011-2018). key outcomes include incidence overall any specific diseases. associations among different sites 10 independent risks also...
To evaluate the influence of target dose heterogeneity on normal tissue sparing for peripheral lung tumor stereotactic body radiation therapy (SBRT).Based volumetric-modulated arc (VMAT) technique, three SBRT plans with homogeneous, moderate heterogeneous, and heterogeneous (HO, MHE, HE) doses were compared in 30 patients. The prescription was 48 Gy 4 fractions. Ten rings outside PTV created to limit dosage falloff.When MHE HE HO plans, conformity index increased by approximately 0.08....
Abstract: Arboleda-Tham syndrome (OMIM#616268) is a newly named neurodevelopmental disorder, which an autosomal dominant hereditary disease characterized by genetic variants. The clinical manifestations include global developmental delay, primary microcephaly, and craniofacial dysmorphism, as well more varied features such feeding difficulties, cardiac defects, ocular anomalies. Currently, due to restricted knowledge of less specific pathological manifestations, it difficult diagnose at the...
Background: To develop nomograms for predicting recurrence risk and long-term survival in patients with parotid gland cancer (PGC). Methods: A total of 301 consecutive PGC who underwent surgery were enrolled randomly divided into a training cohort (n=210) validation (n=91). Predictive constructed based on the independent indicators overall (OS) disease-free (DFS) as determined by multivariate Cox regression analysis. The discrimination calibration evaluated using C-indices curves. Results:...
To evaluate the efficiency of local radiotherapy to metastatic lesions in patients with nasopharyngeal carcinoma (mNPC).The overall survival was observed and compared for mNPC who received versus nonradiotherapy by using Kaplan-Meier method Cox analysis.One hundred nine NPC were involved this study, 61 (56.0%) sites 48 (44.0%) did not receive sites. The 2- 5-year OS 65.8% 35.7%, 45.3% 26.2%. multivariable adjusted hazard radios 0.482 (95% confidence interval is 0.278-0.834, p = 0.009).Local...
14634 Background: Inhibition of angiogenesis is a promising approach to treat cancer. Endostatin, the COOH-terminal proteolytic fragment basement membrane component collagen XVIII, represents one most potent endogenous angiogenic inhibitors. Recombinant human endostatin adenoviruses (Ad-hE), encapsulated with (Ad-hE/Lipo) and without liposome, were evaluated for their potential anti-tumor activity. Methods: MTT colorimetric assay was used evaluate inhibition on umbilical vein endothelial...
Zhu-Tokita-Takenouchi-Kim (ZTTK) is a rare disorder caused by heterozygous variants of SON gene, which an autosomal dominant genetic disease, with only 32 cases and 25 causative in have been reported to date since the first report 2015. Herein, we 2 additional sporadic clinical features strikingly similar having reported. Notably, through penetration left palm print growth hormone deficiency our Patient #1 has not mentioned literature. Whole-exome sequencing revealed novel variants, c.5297...