A5076694130- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Urinary and Genital Oncology Studies
- Nanowire Synthesis and Applications
- Silicon Nanostructures and Photoluminescence
- Advanced Biosensing Techniques and Applications
- Cancer-related gene regulation
- Nanoparticles: synthesis and applications
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Fibroblast Growth Factor Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Electrochemical sensors and biosensors
- Chronic Myeloid Leukemia Treatments
- Cytokine Signaling Pathways and Interactions
- Anodic Oxide Films and Nanostructures
- Plasmonic and Surface Plasmon Research
- Graphene and Nanomaterials Applications
- Iron oxide chemistry and applications
- Characterization and Applications of Magnetic Nanoparticles
- Biosensors and Analytical Detection
- Electrospun Nanofibers in Biomedical Applications
- Nanopore and Nanochannel Transport Studies
Hospital General de Granollers
2018
Hospital Universitario La Paz
2011-2014
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2011-2014
Spanish National Cancer Research Centre
2008-2012
Centro de Investigación del Cáncer
2010
Universidad de Navarra
2008
Accurate detection and quantification of biomarkers at ultra-low levels is critical for disease diagnosis effective treatment. Traditional technologies often lack the sensitivity, specificity, throughput, or multiplexing capacity required comprehensive diagnostics, providing only a subset these requirements. Here, we introduce AVAC, an automated optical technology rapid accurate biomarker with ultra-high sensitivity that significantly outperforms standard clinical assays. The core this...
Abstract Purpose: Polyamines are important regulators of cell growth and death. The polyamine modulated factor-1 (PMF-1) is involved in homeostasis. After identifying an enriched CpG island encompassing the PMF1 promoter, we aimed at evaluating clinical relevance methylation bladder cancer. Experimental Design: epigenetic silencing by hypermethylation was tested cancer cells (n = 11) after azacytidine treatment. status evaluated 507 tumors 118 urinary specimens patients controls. protein...
Bacillus Calmette-Guerin is standard treatment to decrease tumor recurrence and delay progression of high risk, nonmuscle invasive bladder tumors. However, it not yet clear which T1G3 cases are more prone aggressive clinical behavior or susceptible respond bacillus Calmette-Guerin. We evaluated the role myopodin methylation as a outcome prognosticator predictive biomarker for response in patients with tumors.We analyzed status specimens from 170 cancer, including subset 108 who underwent...
Myopodin is an actin-binding protein that shuttles between the nucleus and cytoplasm. After identifying enriched CpG island encompassing transcription site of myopodin, we aimed at evaluating potential relevance myopodin methylation in bladder cancer. The epigenetic silencing by hypermethylation was tested cancer cells (n=12) before after azacytidine treatment. associated with gene expression, being increased vitro this demethylating agent. status promoter then evaluated methylation-specific...
In the rapidly emerging field of biomedical applications, multifunctional nanoparticles, especially those containing magnetic and plasmonic components, have gained significant attention due to their combined properties. These hybrid systems, often composed iron oxide gold, provide both optical functionalities offer promising avenues for applications in multimodal bioimaging, hyperthermal therapies, magnetically driven selective delivery. This paper focuses on implementation advanced...
Plasmonic-based biosensors have gained prominence as potent optical biosensing platforms in both scientific and medical research, attributable to their enhanced sensitivity precision detecting biomolecular chemical interactions. However, the detection of low molecular weight analytes with high specificity remains a complex unresolved issue, posing significant limitations for advancement clinical diagnostic tools device technologies. Notably, abnormal cholesterol levels are well-established...
Plasmonic-based biosensors have gained prominence as potent optical biosensing platforms in both scientific and medical research, attributable to their enhanced sensitivity precision detecting biomolecular chemical interactions. However, the detection of low molecular weight analytes with high specificity remains a complex unresolved issue, posing significant limitations for advancement clinical diagnostic tools device technologies. Notably, abnormal cholesterol levels are well-established...
On the Cover: A methodology is described for nonlinear contrast-enhanced unsupervised segmentation of multispectral microscopy images principally unstained specimens.The method exploits spectral diversity and spatial sparseness to find anatomical differences between cells, nuclei, background.Shown a segmented image sciatic nerve fibers used validation.(See page 547.
Supplementary Data from Identification of PMF1 Methylation in Association with Bladder Cancer Progression
<div>Abstract<p><b>Purpose:</b> Polyamines are important regulators of cell growth and death. The polyamine modulated factor-1 (PMF-1) is involved in homeostasis. After identifying an enriched CpG island encompassing the PMF1 promoter, we aimed at evaluating clinical relevance methylation bladder cancer.</p><p><b>Experimental Design:</b> epigenetic silencing by hypermethylation was tested cancer cells (<i>n</i> = 11) after...
<div>Abstract<p><b>Purpose:</b> Polyamines are important regulators of cell growth and death. The polyamine modulated factor-1 (PMF-1) is involved in homeostasis. After identifying an enriched CpG island encompassing the PMF1 promoter, we aimed at evaluating clinical relevance methylation bladder cancer.</p><p><b>Experimental Design:</b> epigenetic silencing by hypermethylation was tested cancer cells (<i>n</i> = 11) after...
Supplementary Data from Identification of PMF1 Methylation in Association with Bladder Cancer Progression