A5031480179- Heart Rate Variability and Autonomic Control
- Pharmacogenetics and Drug Metabolism
- Cardiovascular and exercise physiology
- Blood Pressure and Hypertension Studies
- Anesthesia and Sedative Agents
- Pharmaceutical studies and practices
- Pharmaceutical Practices and Patient Outcomes
- Ethics in Clinical Research
- Pharmacological Effects and Toxicity Studies
- Cardiovascular Health and Disease Prevention
- Pain Management and Opioid Use
- Anesthesia and Pain Management
- Cardiovascular Syncope and Autonomic Disorders
- Treatment of Major Depression
- Neuroscience of respiration and sleep
- Health Sciences Research and Education
- Nitric Oxide and Endothelin Effects
- Intensive Care Unit Cognitive Disorders
- Biomedical Ethics and Regulation
- Sodium Intake and Health
- Opioid Use Disorder Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Diet and metabolism studies
- Optical Imaging and Spectroscopy Techniques
- Pharmacology and Obesity Treatment
Mayo Clinic in Arizona
2015-2025
Mayo Clinic
2013-2023
WinnMed
2006-2021
Mayo Clinic in Florida
2019
University of Minnesota Rochester
2016-2019
Mayo Clinic Hospital
2015-2018
University of Florida
2018
Columbus Oncology and Hematology Associates
2018
University of New Hampshire at Manchester
2014
U.S. Army Research Institute of Environmental Medicine
2013
The autonomic nervous system plays a central role in both acute and chronic blood pressure regulation humans. activity of the sympathetic branch is positively associated with peripheral resistance, an important determinant mean arterial men. In contrast, there no association between nerve resistance women before menopause, yet positive after menopause. We hypothesized that support higher menopause women. examined effect ganglionic blockade on how this relates to baseline muscle 12 young...
Background:Reliability of continuous glucose monitors (CGM) is a prerequisite for therapeutic dosing insulin without the need confirmatory blood meter measurements. Interference CGMs with commonly prescribed substances has not been extensively evaluated. Methods:We sought to undertake novel pilot study determine susceptibility FDA-approved CGM systems (Medtronic Guardian Sof-Sensor, Dexcom G4 Platinum) erroneous readings in presence common medications. were placed on abdomen healthy subjects...
Aging is associated with reduced endothelial function. There indirect evidence for prostacyclin (PGI(2))-mediated vasodilation aging, but it unknown whether this because of dilation to PGI(2) or altered production. In addition, the contribution NO PGI(2)-mediated unknown. Using plethysmography determine forearm blood flow, we studied effect in 10 older (61 73 years) and younger (19 45 subjects using 3 escalating intra-arterial doses (epoprostenol). was also administered after synthase...
Blood flow and vasodilatory responses are altered by age in a number of vascular beds, including the cerebral circulation. To test role prostaglandins as regulators function, we examined vasodilator to CO(2) (cerebrovascular reactivity) young (26 ± 5 yr; 6 males/6 females) older (65 yr, males/5 healthy humans before after cyclooxygenase inhibition (using indomethacin). Middle artery velocity (MCAv) stepped hypercapnia were measured 90 min indomethacin. Changes MCAv during recovery from...
Central (aortic) blood pressure, arterial stiffness, and sympathetic nerve activity increase with age in women. However, it is unknown if the age-related influences aortic hemodynamics carotid-femoral pulse wave velocity (cfPWV), an index of central stiffness. The goal this study was to determine cfPWV are directly influenced by measuring hemodynamics, cfPWV, muscle (MSNA) women before during autonomic ganglionic blockade trimethaphan camsylate. We studied 12 young premenopausal (23 ± 4 yr)...
Autonomic support of blood pressure increases with age in humans. Large differences exist the dose trimethaphan (TMP) required for ganglionic blockade young and older women. We asked whether TMP to achieve are because relative contributions sympathetic parasympathetic nervous system control age. Muscle nerve activity (microneurography, peroneal nerve), heart rate (HR), were recorded before during incremental doses camsylate until was achieved (absence muscle <5-bpm increase HR a valsalva...
BACKGROUND Periintubation hypotension is associated with poor outcomes in the critically ill. We aimed to determine if an admixture of ketamine and propofol for emergent endotracheal intubation ill patients was superior etomidate. Primary endpoint change mean arterial pressure from baseline 5 minutes postdrug administration. METHODS Emergent-use, stratified (shock status unit type), multiunit, randomized, parallel-group superiority clinical trial conducted at a tertiary academic medical...
Abstract Menopause is associated with vascular dysfunction. During the menopausal transition, endogenous oestradiol concentrations diminish. Oestradiol vasoprotective because it has direct and indirect effects on vasculature. The present study aimed to determine effect of acute exogenous endothelium‐dependent, endothelium independent β 2 ‐adrenergic receptor‐induced vasodilatation in females. Forearm blood flow (venous occlusion plethysmography) was measured during brachial intraarterial...
Abstract Pharmacokinetics and antithrombotic effects of the Factor Xa inhibitor rivaroxaban were studied in subjects with mild renal insufficiency concurrently taking P‐glycoprotein moderate CYP3A verapamil, a drug commonly administered to patients hypertension, ischemic heart disease, or atrial fibrillation. Age‐matched controls normal function concurrently. Subjects’ overall mean age was 59 years. Mean creatinine clearance values 2 groups 105 71 mL/min. After single 20‐mg oral doses, area...
A number of barriers exist for adoption pharmacogenomics into practice. Physicians, pharmacists, and nurses report limited knowledge about its use in patient care. Lack education curricula as part professional schools or postgraduate training programs has been reported a potential cause. Understanding is further complicated by complex nonstandard lexicon, medication guidelines, rapidly changing evidence, insufficient awareness test availability utility.
Pharmacogenomics (PGx) clinical decision support integrated into the electronic health record (EHR) has potential to provide relevant knowledge clinicians enable individualized care. However, past experience implementing PGx multiple EHR platforms identified important clinical, procedural, and technical challenges. Commercial EHRs have been widely criticized for lack of readiness implement precision medicine. Herein, we share our experiences lessons learned new functionality charting...
Opioid treatment of chronic noncancer pain (CNCP) adds complexity and uncertainty to patient interactions. We sought assess clinician attitudes, beliefs, practice styles, concerns around opioid prescribing following the release US Centers for Disease Control Prevention (CDC) guideline opioids pain. E-mailed electronic survey clinicians at a large academic medical institution. A total 961 responded (response rate = 40%), 720 whom prescribed were not in training. Sixty-five percent physicians,...
Dietary sodium and blood pressure regulation differs between normotensive men women, an effect which may involve endothelial production of nitric oxide (NO). Therefore, we tested the hypothesis that differences in NO component endothelium-dependent vasodilation low high dietary intake depend on sex. For 5 days prior to study, healthy adults consumed a controlled low-sodium diet (10 mmol/day, n = 30, mean age ± SE: 30 1 yr, 16 men) or high-sodium (400 36, 23 13 men). Forearm flow (FBF,...