A5064644942- Traditional Chinese Medicine Analysis
- Veterinary medicine and infectious diseases
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Toxin Mechanisms and Immunotoxins
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Microbial Natural Products and Biosynthesis
- Plant tissue culture and regeneration
- Chromatography in Natural Products
- Immune cells in cancer
- Fungal Biology and Applications
- Algal biology and biofuel production
- Biocrusts and Microbial Ecology
- Metabolomics and Mass Spectrometry Studies
- Bioactive Compounds and Antitumor Agents
- Advanced Drug Delivery Systems
- Computational Drug Discovery Methods
- Food Quality and Safety Studies
- Natural product bioactivities and synthesis
- Polysaccharides and Plant Cell Walls
- Coccidia and coccidiosis research
- Milk Quality and Mastitis in Dairy Cows
- Neuroinflammation and Neurodegeneration Mechanisms
- Fungal Plant Pathogen Control
Lanzhou Institute of Husbandry and Pharmaceutical Sciences
2013-2025
Ministry of Agriculture and Rural Affairs
2020-2025
PLA Army Engineering University
2024
New Technology (Israel)
2023
Chinese Academy of Agricultural Sciences
2011-2016
Qingdao Municipal Center for Disease Control and Prevention
2016
Pingliang People's Hospital
2013
Jilin University
2012
The escalating demand for enhanced therapeutic efficacy and reduced adverse effects in the pharmaceutical domain has catalyzed a new frontier of innovation research field pharmacy: novel drug delivery systems. These systems are designed to address limitations conventional administration, such as abbreviated half-life, inadequate targeting, low solubility, bioavailability. As disciplines pharmacy, materials science, biomedicine continue advance converge, development efficient safe systems,...
The redox system is closely related to changes in cellular metabolism. Regulating immune cell metabolism and preventing abnormal activation by adding antioxidants may become an effective treatment for oxidative stress inflammation-related diseases. Quercetin a naturally sourced flavonoid with anti-inflammatory antioxidant activities. However, whether quercetin can inhibit LPS-induced inflammatory macrophages affecting immunometabolism has been rarely reported. Therefore, the present study...
Oxidative stress refers to the phenomenon in which redox balance of body is disrupted response stimuli, leading an excessive accumulation reactive oxygen species vivo, can lead a variety diseases. In contrast artificial antioxidants, whose safety controversial, natural are widely available, pharmacologically active, and have little toxic side effects, expected be candidates for treatment oxidative stress-related Polygonum viviparum L. (PV) herbal medicine with antioxidant properties used as...
SUMMARY Hand, foot, and mouth disease (HFMD) has caused public health concerns worldwide. We aimed to investigate the effect of meteorological factors on HFMD epidemic in Qingdao, a port city China. A total 78641 cases were reported Qingdao between January 2007 December 2014. Of those, 71084 (90·39%) occurred children aged 0–5 years, with an incidence 1691·2/100000. The increased from early spring, peaked spring summer, decreased late summer. Aetiological agents all severe selected mild...
Abstract Background Py-mulin is a new pleuromutilin derivative with potent antibacterial activities in vitro and vivo, suggesting this compound may lead to promising drug after further development. The present study aimed evaluate the acute subacute oral toxicity, genotoxicity standard Ames test according protocols. Methods Acute toxicity of was determined using Kunming mice. 28-day repeated dose SD rats performed OECD guideline No. 407. bacterial reverse mutation (Ames test) carried out...
In this paper, Nostoc commune crude polysaccharide was extracted by heating and Ultrasonic-assisted methods separately, homogeneous HNCP3 UNCP4 were obtained after purified DEAE-52 cellulose column chromatography Sephacryl G-100 gel chromatography. The structures of characterized molecular weight determination, infrared spectroscopy, DSC detection, sodium periodate oxidation, smith degradation reaction methylation analysis. conformation the solution studied SEM AFM. results showed that...
The fruits of Ailanthus altissima Swingle (AS) possess a variety pharmacological activities. Its antioxidant activity and the potential mode action have not yet been investigated. In in vitro studies, AS revealed strong reducing power DPPH scavenging effect, but hydroxyl radical ferrous ions-chelating ability were strong. Meanwhile, oxidative stress RAW264.7 cell injury model was established, low medium-doses showed significant protective effects on viability H2O2-treated cells by CCK-8...
To investigate the effect of polymer blends on in vitro release/degradation and pharmacokinetics moxidectin-loaded PLGA microspheres (MOX-MS), four formulations (F1, F2, F3 F4) were prepared using O/W emulsion solvent evaporation method by blending high (75/25, 75 kDa) low (50/50, 23 molecular weight with different ratios. The addition low-molecular-weight did not change release mechanism microspheres, but sped up drug drastically shortened lag phase. degradation results show that consisted...
Oxidative stress is the redox imbalance state of organisms that involves in a variety biological processes diseases. Limonium aureum (L.) Hill. an excellent wild plant resource northern China, which has potential application value for treating oxidative stress. However, there are few studies focused on antioxidant effect and related mechanism L. . Thus, present study combining systematic network pharmacology molecular biology aimed to investigate effects explore its underlying anti-oxidation...
Salmonella infections pose a significant threat to animal and human health. Phytochemicals present potential alternative treatment. Galla chinensis tannic acid (GCTA), hydrolyzable polyphenolic compound, inhibits bacterial growth demonstrates as an or supplement antibiotics prevent infections. However, little is known about the antimicrobial mechanism of GCTA against Salmonella. Here, we revealed 456 differentially expressed proteins upon treatment, impacting pathways related DNA...
Swainsonine (SW) is a substance with both animal neurotoxicity and natural anticancer activity produced by the metabolism of endophytic fungus Alternaria section Undifilum oxytropis locoweed. This paper SW fermentation A. locoweed obtained optimal ultrasonic-assisted extraction process response surface methodology. Meanwhile, four mutant strains significant stable SW-producing properties were screened out after mutagenesis heavy-ion irradiation. Of these, three high-yielding stains one was...
Inflammation is the host response of immune cells during infection and traumatic tissue injury. An uncontrolled inflammatory leads to cascade, which in turn triggers a variety diseases threatening human animal health. The use existing therapeutic drugs constrained by their high cost susceptibility systemic side effects, therefore new candidates for need be urgently developed. Natural products are characterized wide sources rich pharmacological activities, valuable resources development...
Melophagus ovinus disease is a common ectoparasitosis, which can lead to decrease in animal production performance, product quality, and even death. Aconitum flavum Hand.-Mazz. has many pharmacological activities including insecticidal, heat-clearing, analgesic, dehumidifying. However, there are few researches focused on the effects related mechanism of killing . In this study, 11 alkaloids were detected, its total alkaloid activity was determined. The results showed when concentration 64...
Simiao Yong'an decoction (SYD) is a classic traditional Chinese medicine (TCM) prescription that has the effects of clearing heat, detoxifying, promoting blood circulation, and relieving pain. In this study, we investigated effect SYD on diversity intestinal microbiota after fermentation by Bacillus subtilis. was fermented using B. Female Sprague-Dawley rats were randomly divided into following four groups with six in each group: Negative sample group (NS), water exaction non-fermentation...
The aim of the present study was to establish a simple and reliable ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method apply it for determination pharmacokinetics moxidectin-loaded microspheres (MOX-MS) in rats. Plasma samples were processed using simplified liquid-liquid extraction separated an Agilent Zorbax Eclipse Plus C18 column (50 mm × 2.1 mm, 1.8 μm) with mobile phase consisting 10 mM ammonium formate solution 0.1% formic acid (A) acetonitrile...
To evaluate the acute and chronic 28-day repeated-dose oral toxicity of Guixiong Yimu San (GYS) in mice rats, high-performance liquid chromatography (HPLC) was used to determine stachydrine hydrochloride GYS as quality control. In trial, were administered orally at a dose rate 30.0 g GYS/kg body weight (BW) three times day. The general behavior, side effects, death noticed for 14 days following treatment. subacute rats rates of30.0, 15.0, 7.5 BW once day 28 days. monitored every clinical...