A5101491656- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Acute Myeloid Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Dermatological and COVID-19 studies
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Public Health in Brazil
- Environmental and biological studies
- Parvovirus B19 Infection Studies
- Water Quality and Pollution Assessment
- Bee Products Chemical Analysis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood properties and coagulation
- Viral-associated cancers and disorders
- Hemoglobinopathies and Related Disorders
- Genomics and Rare Diseases
- T-cell and Retrovirus Studies
- Maternal and Neonatal Healthcare
- Phytochemistry and biological activity of medicinal plants
- Healthcare during COVID-19 Pandemic
- DNA Repair Mechanisms
- Eosinophilic Disorders and Syndromes
Universidade Estadual de Campinas (UNICAMP)
2025
Instituto do Câncer do Estado de São Paulo
2021-2024
Universidade de São Paulo
2021-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2020-2022
Fundação Pró-Sangue Hemocentro de São Paulo
2021
Abstract Genetic diversity of germline variants in breast cancer (BC) predisposition genes is unexplored miscegenated populations, such those living Latin America. We evaluated 1663 Brazilian BC patients, who underwent hereditary multigene panel testing (20–38 susceptibility genes), to determine the spectrum and prevalence pathogenic/likely pathogenic (P/LP) uncertain significance (VUS). Associations between P/LP risk were estimated a case–control analysis patients 18,919 reference controls...
Managing chronic myeloid leukemia during pregnancy presents significant challenges, with limited treatment options available depending on the stage of pregnancy. All existing tyrosine kinase inhibitors are considered teratogenic, especially first trimester and should be avoided. In this case report, we detail successful, unplanned dichorionic diamniotic twin a patient chronic-phase previously resistant to imatinib dasatinib who was exposed allosteric inhibitor asciminib early weeks...
To identify somatic mutations in tumors from young women with triple-negative or luminal breast cancer, through targeted sequencing and to explore the cancer driver potential of these gene variants.
Objetivo: Analisar a eficácia de ferramentas triagem para detecção precoce sepse. Métodos: Estudo prospectivo, que abrangeu 443 protocolos sepse um hospital quaternário no Rio Janeiro entre janeiro e agosto 2023. Foram comparadas sensibilidade especificidade três ferramentas: síndrome da resposta inflamatória sistêmica, quick Sepsis Related Organ Failure Assessment (qSOFA) National Early Warning Score (NEWS). Resultados: Dentre os pacientes com choque séptico, 88% apresentaram NEWS > 4,...
Lesões locomotoras em equinos são causa comum de solicitação da Medicina Veterinária, afetando cavalos qualquer idade, gênero ou raça, trazendo prejuízos econômicos à equideocultura. O presente trabalho descreve o tratamento uma lesão membro posterior égua quarto milha cinco anos, utilizando Plasma Rico Plaquetas (PRP) e associação gel babosa (Aloe vera) açúcar cristal. Durante os dois primeiros meses tratamento, a foi higienizada com água corrente administrado sulfadiazina prata 1.0%....
e16263 Background: Despite being one of the deadliest tumors worldwide, hereditary factors involved in PC are not fully understood. Thus, our objective is to assess prevalence germline mutations cohorts selected for FH. Methods: A systematic review was performed, using descriptors related and mutations, employing Pubmed, Lilacs, Web Science Embase, until August/2020. Three investigators were reviewing titles abstracts by peers. Exclusions comprehended articles non-English language, studies...
A trombocitopenia persistente é frequentemente encontrada em pacientes submetidos ao transplante de células progenitoras hematopoiéticas (TCPH). transfusão plaquetas considerada parte essencial no tratamento e pode ser caráter profilático ou terapêutico. refratariedade plaquetária (RP) um dos problemas mais desafiadores contexto do transplante, porque apresenta uma ampla variedade causas não imunes imunes. Em relação às imunes, a fisiopatogenia corresponde à aloimunização por anticorpos...
Background: Thrombotic events in newly diagnosed patients with acute myeloid leukemia (AML) have been considered rare and not received a great deal of attention. These may occur at the diagnosis, during remission induction, or later. The incidence thromboembolism AML varied markedly among studies, ranging from 2 to 13%, are usually divided between arterial venous events. Limited evidence points that using markers disseminated intravascular coagulation (DIC) might predict thrombosis AML,...
Introduction: Diffuse Large B cell Lymphoma (DLBCL) is a heterogenous disease. Factors based on clinical and simple laboratory parameters are known widely used such as the Revised International Prognostic Index (R-IPI) National Comprehensive Cancer Network -IPI (NCCN-IPI). Thus, we aimed to report real world experience of outcomes DLBCL lymphoma patients treated in Brazilian public cancer institution evaluate prognostic role R-IPI NCCN-IPI. Methods: This an unicenter registry study including...
Abstract Genetic diversity of germline variants in breast cancer (BC) predisposition genes, is unexplored miscegenated people, such as Latin American populations. We evaluated 1,662 Brazilian BC patients, who underwent hereditary multi-gene panel testing (20–38 susceptibility genes), to determine the spectrum and prevalence (likely) pathogenic (P/LP) uncertain significance (VUS). In total, 161 (9.7%) participants carried P/LP BRCA1/2 162 other genes. Overall, 341 distinctive were identified...
Distinction between hereditary macrothrombocytopenias(HM) and immune thrombocytopenia (ITP) can be challenging due to the lack of specific tests, increasing risk misdiagnosis incorrect treatments. Previous studies have shown that immature platelet fraction (IPF) values are influenced by size could a convenient parameter when segregating from these two differential diagnosis thrombocytopenia. In this study, we tried further understand usefulness IPF as screening tool for...
In October 2018, a recommendation on the management of venous thromboembolism in cancer patients was developed at ICESP-HCFMUSP and included rivaroxaban as new anticoagulant. To raise awareness an extensive educational plan organized introductory outpatient clinic carried out to check eligibility switch from enoxaparin rivaroxaban. 'Alô Enfermeiro'is 24/7 institutional call center for patients, managed by nurses. order empower them ensure they would be able reply accordingly, their training...