A5076785471- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Nutrition, Genetics, and Disease
- RNA modifications and cancer
- Vitamin D Research Studies
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lymphoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Head and Neck Cancer Studies
- Cancer-related gene regulation
- Estrogen and related hormone effects
- TGF-β signaling in diseases
- DNA Repair Mechanisms
- MicroRNA in disease regulation
Universidade de São Paulo
2014-2025
Instituto do Câncer do Estado de São Paulo
2011-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2006-2024
University of Groningen
2018
University Medical Center Groningen
2018
Hospital de Clínicas
2018
Universidade Federal de São Paulo
2005-2006
Hospital Heliópolis
2004-2006
Universidade Estadual de Campinas (UNICAMP)
2000
Approximately 8-15% epithelial ovarian cancer patients are BRCA1 or BRCA2 germline mutation carriers. Brazilian inhabitants may have peculiar genetic characteristics associated with ethnic diversity, and studies focusing on the entire BRCA1/BRCA2 gene sequencing in still lacking. The aim of this study was to evaluate BRCA1/2 mutations, through sequencing, a population women cancer.In cross sectional performed one reference centre for treatment São Paulo, Brazil, 100 diagnosed unselected...
The contribution of CDH1 germline variants to gastric cancer burden among young adults is unknown in Brazil. We aimed evaluate the frequency and diet/lifestyle habits early age onset (EOGC, ≤ 55 years old) patients.From 2013 2015, a total 88 unrelated consecutive patients diagnosed with EOGC were enrolled. All exons intronic boundaries sequenced, large genomic rearrangements screened by MLPA. transcription analysis was performed for that could potentially induce an effect on splicing. diet...
// Giselly Encinas 1, * , Veronica Y. Sabelnykova 2, Eduardo Carneiro de Lyra 3 Maria Lucia Hirata Katayama 1 Simone Maistro Pedro Wilson Mompean Vasconcellos Valle Gláucia Fernanda Lima Pereira Lívia Munhoz Rodrigues Adolpho Menezes Pacheco Serio Ana Carolina Ribeiro Chaves Gouvêa Felipe Correa Geyer Ricardo Alves Basso Fátima Solange Pasini del Pilar Esteves Diz Mitzi Brentani João Carlos Guedes Sampaio Góes Roger Chammas Paul C. Boutros 4, 5 and Aparecida Azevedo Koike Folgueira Instituto...
Breast cancer stromal compartment, may influence responsiveness to chemotherapy. Our aim was detect a cell signature (using direct approach of microdissected cells) associated with response neoadjuvant chemotherapy (neoCT) in locally advanced breast (LABC). The tumor samples were collected from 44 patients LABC (29 estrogen receptor (ER) positive and 15 ER negative) before the start any treatment. Neoadjuvant consisted doxorubicin cyclophosphamide, followed by paclitaxel. Response defined as...
To test if the expression of Smad1-8 mRNAs were predictive survival in patients with oral squamous cell carcinoma (SCC). We analyzed, prospectively, Smad1-8, by means Ribonuclease Protection Assay 48 primary, operable, SCC. In addition, 21 larynx, 10 oropharynx and 4 hypopharynx SCC 65 matched adjacent mucosa, available for study, also included. For analysis, categorized as positive or negative each Smad, according to median mRNA expression. performed real-time quantitative PCR (QRTPCR)...
Triple-negative breast cancer (TNBC) and High-Grade Serous Ovarian Cancer (HGSOC) are aggressive malignancies that share similarities; however, different ages of onset may reflect distinct tumor behaviors. Thus, our aim was to compare somatic mutations in potential driver genes 109 TNBC 81 HGSOC from young (Y ≤ 40 years) elderly (E ≥ 75 patients.Open access mutational data (WGS or WES) were collected for patients. Potential those present the Gene Census-CGC, Candidate Database-CCGD, OncoKB...
To explore the prognostic role of plasma levels osteopontin (OPN), a phosphoglycoprotein with adhesive properties, in patients head and neck squamous cell carcinoma (HNSCC) undergoing concomitant chemoradiotherapy. Previous studies have proposed OPN level as factor several cancers.Prospective analysis levels, before within 12 weeks after treatment, cohort HNSCC platinum-based chemoradiotherapy at our center.Academic center.Sixty-nine diagnosed having HNSCC.Plasma were assessed start...
Previous knowledge of cervical lymph node compromise may be crucial to choose the best treatment strategy in oral squamous cell carcinoma (OSCC). Here we propose a set four genes, whose mRNA expression primary tumor predicts nodal status OSCC, excluding tongue.We identified differentially expressed genes OSCC with and without compromised nodes using Differential Display RT-PCR. Known were chosen validated by means Northern blotting or real time RT-PCR (qRT-PCR). Thereafter constructed Nodal...
Vitamin D seems to be an important determinant of prostate cancer risk and inherited polymorphisms in the 3'untranslated region vitamin receptor (VDR) gene have been associated with progression some populations. We therefore studied VDR polymorphisms, as detected by Apal Taql restriction fragments, multiethnic Brazilian men (165 patients 200 controls) for association parameters disease severity (serum PSA, Gleason score tumor stage). No statistical correlations were found. The unique...
OBJECTIVE: To analyze the cost effectiveness of diagnostic program for germline mutation in BRCA1/2 genes and preventative strategies relatives patients diagnosed with ovarian cancer associated this mutation. METHODS: The study analyzed by developing an analysis Markov decision process from perspective National Health System. compared reflect upon adoption genetic testing or usual care currently proposed. incremental cost-effectiveness ratio was expressed terms per case avoided. sensitivity...
In breast cancer (BC) patients, the frequency of germline BRCA mutations (gBRCA) may vary according to ethnic background, age, and family history cancer. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) is second most common somatic mutated gene in BC; however, association both genes with has not been thoroughly investigated. Thus, our aims were investigate gBRCA mutation a cohort postmenopausal Brazilian BC patients gBRCA1/BRCA2 PIK3CA mutations.Forty-nine...
Vitamin D seems to be an important determinant of prostate cancer risk and inherited polymorphisms in the 3'untranslated region vitamin receptor (VDR) gene have been associated with progression some populations. We therefore studied VDR polymorphisms, as detected by Apal Taql restriction fragments, multiethnic Brazilian men (165 patients 200 controls) for association parameters disease severity (serum PSA, Gleason score tumor stage). No statistical correlations were found. The unique...
OBJECTIVES: Cancer in young adults represents a great challenge, both biologically and socially, understanding the unique characteristics of neoplasms this age group is important to improving care.We aimed evaluate most common carcinomas their characteristics, such as histological type clinical stage, largest cancer hospital Latin America.METHODS: The registry was consulted for period between 2008 2014.Young were defined individuals aged 18 39 years, older 40 years older.Differences groups...
to analyze factors that might indicate familial predisposition for ovarian cancer in patients diagnosed with this disease.in a prospective single center cohort study at the Institute of Cancer State São Paulo (ICESP), 51 women were included. Familial was defined as having higher than 10% chance BRCA1/2 mutation according Manchester scoring system, validated method assess likelihood detection. Each patient interviewed standardized questionnaire on established risk and other influence develop...
A close correlation between vitamin D receptor (VDR) abundance and cell proliferation rate has been shown in NIH-3T3 fibroblasts, MCF-7 breast cancer HL-60 myeloblastic cells. We have now determined if this association occurs other leukemic lines, U937 K562, VDR content is related to c-myc expression, which also linked growth state. Upon phorbol myristate acetate (PMA) treatment, cells from the three lineages (HL-60, K562) differentiated expressed specific surface antigens. All lines...
<p>Supplementary Figure 4A: KM curve of PSA-PFS in patients with and without PD-L1 expression.</p>
Abstract Purpose Brazil has a highly admixed population. Polygenic Risk Scores (PRS) have been mostly developed from European population studies and applying them to other populations is challenging. To assess the use of PRS for breast cancer (BC) risk in Brazil, we validated four PRSs Brazilian Patients Methods We analyzed 6,362 women with history 9,128 unphenotyped adults as controls sample obtained clinical laboratory. Genomic variants were imputed exomes scores calculated all samples....
e18030 Background: Smoking and alcohol abuse are the main risk factors for head neck squamous cell carcinoma. However, some patients do not present clear factors. We studying a cohort of Brazilian that non-smokers alcoholic beverage abstainers. people have peculiar ethnic characteristics, reflecting miscegenation Europeans, Africans Amerindians. There is evidence background may influence germline somatic mutations, as well tumor behavior. One aims to evaluate immune system this miscegenated...
To identify somatic mutations in tumors from young women with triple-negative or luminal breast cancer, through targeted sequencing and to explore the cancer driver potential of these gene variants.