A5106075631- Statistical Distribution Estimation and Applications
- Statistical Methods and Bayesian Inference
- Statistical Methods and Inference
- Bayesian Methods and Mixture Models
- Advanced Statistical Methods and Models
- Reliability and Maintenance Optimization
- Probabilistic and Robust Engineering Design
- Statistical Methods in Clinical Trials
- Forecasting Techniques and Applications
- Fault Detection and Control Systems
- Environmental Toxicology and Ecotoxicology
- Sensory Analysis and Statistical Methods
- Bayesian Modeling and Causal Inference
- Time Series Analysis and Forecasting
- Anomaly Detection Techniques and Applications
- Software Reliability and Analysis Research
- Aquatic Ecosystems and Phytoplankton Dynamics
- Gene expression and cancer classification
- Heavy metals in environment
- Advanced Radiotherapy Techniques
- Nanoparticles: synthesis and applications
- Advanced Statistical Process Monitoring
- Statistical Mechanics and Entropy
- Prostate Cancer Diagnosis and Treatment
- Mathematical Inequalities and Applications
The University of Western Australia
2019-2025
Universidade Federal de São Carlos
2011-2020
Microalgae can be exposed to a gradual copper (Cu) increase over wide concentration range in the environment, but most studies focus on punctual increases. This research investigates effects of quasi-continuous Cu exposure Kirchneriella obesa, providing new insights thresholds healthy and unhealthy cellular responses. Photosynthesis, cell density, biomolecules were measured at 20 free levels, from environmental toxic (3x10−9 4 x 10−5 mol L−1). Using nonlinear Bayesian regression models, we...
Chutes, bins, and hoppers are critical assets in bulk commodity handling. Sacrificial wear liners employed to protect these from abrasive wear. An essential maintenance challenge is optimising the timing of liner replacements. Traditionally, episodic human inspections have been place, but now, real-time wireless IoT sensing systems that measure thickness being used. We propose a novel approach estimate remaining useful chute life. Instead linear extrapolation based on individual sensor rates...
Breast cancer stromal compartment, may influence responsiveness to chemotherapy. Our aim was detect a cell signature (using direct approach of microdissected cells) associated with response neoadjuvant chemotherapy (neoCT) in locally advanced breast (LABC). The tumor samples were collected from 44 patients LABC (29 estrogen receptor (ER) positive and 15 ER negative) before the start any treatment. Neoadjuvant consisted doxorubicin cyclophosphamide, followed by paclitaxel. Response defined as...
This study aimed to investigate cytological abnormalities indicative of chromosome damage (micronuclei) and apoptosis (karyorrhexis, pyknosis, condensed chromatin) in exfoliated cells from the buccal mucosa patients with oral cancer control subjects. The sample included twenty individuals forty normal mucosa. Material was collected cheek epithelium areas lesions without abnormalities. A minimum one thousand analyzed. Micronuclei were found significantly more frequently than areas,...
This article argues that researchers do not need to completely abandon the p-value, best-known significance index, but should instead stop using levels depend on sample sizes. A testing procedure is developed a mixture of frequentist and Bayesian tools, with level function size, obtained from generalized form Neyman–Pearson Lemma minimizes linear combination α, probability rejecting true null hypothesis, β, failing reject false null, fixing α minimizing β. The resulting hypothesis tests...
The goal of this paper is to illustrate how two significance indicesthe frequentist p-value and Bayesian e-value have a straight mathematical relationship. We calculate these indices for standard statistical situations in which sharp null hypotheses are being tested. considered here based on the likelihood ratio statistic. existence functional relationship between could surprise readers because they computed different spaces: p-values sample space e-values parameter space.
The search of alternative compounds to control tropical diseases such as schistosomiasis has pointed secondary metabolites derived from natural sources. Piper species are candidates in strategies the transmission due their production molluscicidal compounds. A new benzoic acid derivative and three flavokawains diospyrifolium, P. cumanense gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, “in silico” studies were performed using docking...
A load-sharing system has several components and the failure of one component can affect lifetime surviving components. Since does not equate to for different designs, analysis dependence structure between becomes a meaningful exercise. The extended sequential order statistics model allows us heterogeneous in systems. However, results may suggest that risk decreases as fail sequentially, which be counterintuitive, especially when data are scarce. We propose address this issue by imposing an...
Abstract The model of extended sequential order statistics (ESOS) comprises two valuable characteristics making the powerful when modelling multi‐component systems. First, components can be assumed to heterogeneous and second, component lifetime distributions change upon failure other components. This degree flexibility comes at cost a large number parameters. exact depends on system size observation depth quickly exceed observations available. Consequently, would benefit from reduction in...
Relevant results for (sub-)distribution functions related to parallel systems are discussed. The reverse hazard rate is defined using the product integral. Consequently, restriction of absolute continuity involved distributions can be relaxed. only that sets discontinuity points have disjointed. Nonparametric Bayesian estimators all survival derived. Dual series use minimum life times as observations, record maximum times. Dirichlet multivariate processes forming a class prior considered...
Abstract Copper (Cu) nanomaterials have been increasingly researched and produced for many different consumer products. They high reactivity bactericidal properties, making them important in antifouling paints, which are thus directly introduced into aquatic ecosystems. However, studies scarce on the behavior of Cu nanoparticles (Cu‐NPs) natural systems their interactions with primary producers such as microalgae. We investigated effects NPs some physiological responses freshwater...
Hypothesis testing in contingency tables is usually based on asymptotic results, thereby restricting its proper use to large samples. To study these tests small samples, we consider the likelihood ratio test (LRT) and define an accurate index for celebrated hypotheses of homogeneity, independence, Hardy-Weinberg equilibrium. The aim understand results frequentist Likelihood Ratio Test Bayesian FBST (Full Significance Test) under small-sample scenarios. proposed exact LRT p-value used as a...
Summary We present a novel semiparametric survival model with log‐linear median regression function. As useful alternative to existing models, our large class has many important practical advantages, including interpretation of the parameters via and ability address heteroscedasticity. demonstrate that modeling technique facilitates ease prior elicitation computation for both parametric Bayesian analysis data. illustrate advantages modeling, as well diagnostics, reanalysis small‐cell lung...
Usually, methods evaluating system reliability require engineers to quantify the of each components. For series and parallel systems, there are limited options handle estimation component's reliability. This study examines complex problems two classes coherent systems: series-parallel, parallel-series. In both cases, component reliabilities may be unknown. We developed estimators for functions at all levels (component reliabilities). The main assumption required is that, distributions...
The goal of this paper is to illustrate how two significance indicesthe frequentist p-value and Bayesian e-value have a straight mathematical relationship. We calculate these indices for standard statistical situations in which sharp null hypotheses are being tested. considered here based on the likelihood ratio statistic. existence functional relationship between could surprise readers because they computed different spaces: p-values sample space e-values parameter space.
Abstract In this article, we will address the complexity of non‐identical components in multi‐component systems. Most technical systems can be described as such since either component types or functions within system vary amongst components. While most reliability related work resorts to assumption homogeneous components, aim often more realistic heterogeneous extending model Extended Sequential Order Statistics by two inferential methods. Firstly, derivation Maximum Likelihood Estimates...
Series system reliability is based on the minimum life time of its components. Its dual, parallel system, maximum. Here, we consider statistical analysis both, series and parallel, systems where components follow Weibull parametric model. Our perspective Bayesian. Due to mathematical complexity, obtain posterior distribution use Metropolis-Hasting simulation method. Based this posterior, evaluated evidence Full Bayesian Significance Test (FBST) for comparing reliabilities The reason using...
The first step in statistical reliability studies of coherent systems is the estimation each system component. For cases parallel and series literature abundant. It seems that present paper presents general case component inferences systems. failure time model considered here three-parameter Weibull distribution. Furthermore, neither independence nor identically distributed times are required restrictions. proposed sense it can be used for any system, from simplest to more complex...
Breast cancer (BC) in young adult patients (YA) has a more aggressive biological behavior and is associated with worse prognosis than BC arising middle aged (MA). We proposed that differentially expressed miRNAs could regulate genes proteins underlying phenotypes of breast tumors YA when compared to those MA patients. Objective: Using integrated expression analyses miRs, their mRNA protein targets stromal gene expression, we aimed identify profiles between from YA-BC MA-BC. Methodology...
The main objective of this paper is to find the relation between adaptive significance level presented here and sample size. We statisticians know inconsistency, or paradox, in current classical tests that are based on p-value statistics compared canonical levels (10%, 5%, 1%): “Raise reject null hypothesis” recommendation some ill-advised scientists! This will show it possible eliminate problem tests. present beginning a larger research project. intention extend its use more complex...
The reliability of a coherent system components depends on the each component and initial statistical work should be an estimation component. This paper represents challenging task because if fails, failure time given cannot observed, that is, phenomenon censored data occurs. A solution for exists when status are available at failure. However, it may difficult to identify moment Such cases represent systems with masked causes Since parallel series simplest systems, numerous solutions have...