A5029927430- Phagocytosis and Immune Regulation
- Erythrocyte Function and Pathophysiology
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Bowel Disease
- Diagnosis and treatment of tuberculosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Intraperitoneal and Appendiceal Malignancies
- Microscopic Colitis
- Appendicitis Diagnosis and Management
- RNA Interference and Gene Delivery
- Lipid metabolism and disorders
- Hernia repair and management
- Pediatric Hepatobiliary Diseases and Treatments
- Abdominal Trauma and Injuries
- Virus-based gene therapy research
- Pancreatitis Pathology and Treatment
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Pancreatic function and diabetes
- Medical Imaging and Pathology Studies
- Ectopic Pregnancy Diagnosis and Management
- Aortic aneurysm repair treatments
- MRI in cancer diagnosis
- Sarcoidosis and Beryllium Toxicity Research
Mallinckrodt (United States)
2015-2025
Washington University in St. Louis
2015-2025
The King's College
2024
Hospital Italiano de Buenos Aires
2024
Inspire Institute
2023
University of Pennsylvania
2006-2020
Drexel University
2012-2017
University College London
2013
University of Washington
2013
Albert Einstein College of Medicine
2012
Foreign particles and cells are cleared from the body by phagocytes that must also recognize avoid clearance of "self" cells. The membrane protein CD47 is reportedly a "marker self" in mice impedes phagocytosis self signaling through phagocyte receptor CD172a. Minimal "Self" peptides were computationally designed human then synthesized attached to virus-size for intravenous injection into express CD172a variant compatible with hCD47. Self delay macrophage-mediated nanoparticles, which...
Phagocytosis of foreign cells or particles by macrophages is a rapid process that inefficient when faced with “self” display CD47—although signaling mechanisms in self-recognition have remained largely unknown. With human macrophages, we show the phagocytic synapse at cell contacts involves basal level actin-driven phagocytosis that, absence species-specific CD47 signaling, made more efficient phospho-activated myosin. We use “foreign” sheep red blood (RBCs) together CD47-blocked,...
Purpose To evaluate the diagnostic performance and interrater reliability of Liver Imaging Reporting Data System (LI-RADS) version 2014 in differentiating hepatocellular carcinoma (HCC) from non-HCC malignancy a population patients at risk for HCC. Materials Methods This retrospective HIPAA-compliant institutional review board-approved study was exempt informed consent. A total 178 pathology-proven malignant liver masses were identified HCC but without established extrahepatic August 2012...
The Liver Imaging Reporting and Data System (LI-RADS) was created to standardize the diagnostic criteria for hepatocellular carcinoma (HCC) has undergone multiple revisions including a recent update in 2018 (v2018). primary aim of this study determine performance interrater reliability (IRR) LI-RADS v2018 distinguishing HCC from non-HCC hepatic malignancy patients 'at-risk' HCC. A secondary assess impact changes introduced algorithm.This retrospective combined 10-year experience...
ABSTRACT The macrophage checkpoint receptor SIRPα signals against phagocytosis by binding CD47 expressed on all cells – including macrophages. Here, we found that inhibiting cis interactions between and the same increased engulfment (‘eating’) approximately level as trans interactions. Antibody blockade of CD47, pursued in clinical trials cancer, was applied separately to human-derived macrophages red blood cell (RBC) targets for phagocytosis, both scenarios produced surprisingly similar...
An earlier incorrect version appeared online. This article was corrected on December 17, 2018.
The slide presentation demonstrates an approach to body MRI for common indications in the abdomen and pelvis, incorporating clinical information, knowledge of imaging patterns, various scoring paradigms.
Epithelial ovarian cancer commonly presents with vague symptoms that delay diagnosis until disease is advanced. Granulomatous peritonitis a term used to describe granulomatous inflammation within the peritoneal cavity and mimics advanced stage clinically on imaging. The goal of this study was examine frequency characteristics cases mimicking at single institution etiology in population. Eight were identified pathology conformation absence cancer. etiologies include pelvic tuberculosis,...
Background Treatment of blunt splenic trauma (BST) continues to evolve with improved imaging for detection vascular injuries. Purpose To report on treatments BST from 11 centers, the frequency and clinical impact injuries, factors influencing treatment. Materials Methods Patients were retrospectively identified as having between January 2011 December 2018, clinical, imaging, outcome data recorded. Patient summarized descriptively, both overall stratified by initial treatment received...
Synaptic loss is the structural basis for memory impairment in Alzheimer’s disease (AD). While underlying pathological mechanism remains elusive, it known that misfolded proteins accumulate as β -amyloid (A ) plaques and hyperphosphorylated Tau tangles decades before onset of clinical disease. The Pin1 facilitates formation these AD. protein controls cell-cycle progression determines fate by ubiquitin proteasome system. activity system directly affects functional plasticity synapse. We...
CT plays a crucial role in the evaluation of stable patients with blunt and penetrating trauma emergency department. Among more severe injuries that may occur are those to inferior vena cava (IVC). The purpose this study was evaluate differentiate findings associated versus IVC aid radiologist diagnosing injuries.Cases injury were retrospectively identified using search queries. Criteria for inclusion preoperative contrast-enhanced surgically confirmed caval or direct on patient death before...
Lentiviruses infect many cell types and are now widely used for gene delivery in vitro, but vivo uptake of these foreign vectors by macrophages is a limitation. Lentivectors produced here from packaging cells that overexpress "Marker Self" CD47, which inhibits macrophage when prophagocytic factors also displayed. Single particle analyses show "hCD47-Lenti" display properly oriented human-CD47 interactions with the macrophage's inhibitory receptor SIRPA. Macrophages derived human...