A5100779225- Tribology and Lubrication Engineering
- Gear and Bearing Dynamics Analysis
- Blood properties and coagulation
- Venous Thromboembolism Diagnosis and Management
- Adhesion, Friction, and Surface Interactions
- Mechanical Circulatory Support Devices
- Ultrasound and Cavitation Phenomena
- Lattice Boltzmann Simulation Studies
- Lubricants and Their Additives
- Fluid Dynamics and Heat Transfer
- Aquatic Ecosystems and Phytoplankton Dynamics
- Surface Modification and Superhydrophobicity
- Cavitation Phenomena in Pumps
- Cardiac Structural Anomalies and Repair
- Advanced Numerical Analysis Techniques
- Microfluidic and Bio-sensing Technologies
- Ultrasound and Hyperthermia Applications
- Rheology and Fluid Dynamics Studies
- Diagnosis and Treatment of Venous Diseases
- Hemostasis and retained surgical items
- Aerosol Filtration and Electrostatic Precipitation
- Aerodynamics and Fluid Dynamics Research
- Erythrocyte Function and Pathophysiology
- Hydraulic and Pneumatic Systems
- Cardiac Imaging and Diagnostics
Tsinghua University
2015-2024
Hebei University of Technology
2010-2024
South China University of Technology
2024
Suzhou Traditional Chinese Medicine Hospital
2009-2019
Nanchang University
2019
Tianjin Nankai Hospital
2012-2018
University of Technology Sydney
2010
Chongqing Academy of Environmental Science
2005-2008
Xiaomi (China)
2005
The deposition of PM2.5 (fine particulate matter in air with diameter smaller than 2.5 μm) lungs is harmful to human health. However, real-time observation on the particles acinar area lung still a challenge experiments. Here, fluorescent imaging method developed visualize process high temporal and spatial resolution. observations reveal that pattern nonuniform, maximum rate differs significantly from prediction widely used average model. also find single kidney liver, though such are...
ZrO 2 ceramic exhibits the characteristics of high hardness, good thermochemical stability, desirable biocompatibility, and unique stress‐activated tetragonal to monoclinic transformation toughening, thus having broad development prospects. However, as a typical material, it has common shortcoming brittleness seriously limits possible applications. In recent years, worldwide efforts have been made improve toughness materials, which great significance in promoting its industrial application....
Background: To determine the clinical activity and safety of Chinese herbal medicine (CHM) combined with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) in patients advanced pulmonary adenocarcinoma (ADC) ability CHM EGFR-TKI to activate EGFR mutations. Methods: Three hundred fifty-four were randomly assigned (erlotinib 150 mg/d, gefitinib 250 or icotinib 125 mg tid/d) plus (TKI+CHM, N = 185) placebo (TKI+placebo, 169). Progression-free survival (PFS) was primary end...
When a transformer is de-energized, the magnetic core material will contain certain amount of residual flux. This flux may intensify saturation and lead to high transient in-rush current upon remagnetizing. paper describes novel method for analyzing detecting flux, based on nonlinear magnetizing characteristics (also called Φ- I characteristics) core. A model toroidal was built simulate transients, which takes process initial energization nonloaded into consideration. The relationship...
An air embolism is induced by intravascular bubbles that block the blood flow in vessels, which causes a high risk of pulmonary hypertension and myocardial cerebral infarction. However, it still unclear how moving bubble stopped to form an small vessels. In this work, microfluidic experiments, vivo vitro, are performed where seen deform stop gradually flow. A clot always found originate at tail bubble, attributed special field around bubble. As grows, breaks lubrication film between channel...
There is a need to improve the efficacy and safety of endovascular techniques in venous thrombotic diseases, microbubble enhanced sonothrombolysis promising approach. However, whether low-frequency ultrasound (LFUS) can be utilized unclear. Here, we present catheter-based thrombolytic system that combines unfocused low-intensity with novel fibrin-targeted drug-loaded bifunctional microbubbles. We develop an vitro flow model vivo rabbit inferior vena cava (IVC) thrombosis evaluate system. The...
Hemolysis usually happens instantly when red blood cells (RBCs) rupture under a high shear stress. However, it is also found to happen gradually in the extracorporeal membrane oxygenation (ECMO) low but periodic squeezes. In particular, gradual hemolysis accompanied by progressive change morphology of RBCs. this work, studied microfluidic device with arrays narrow gaps same as constructions ECMO. RBCs are seen deform periodically they flow through gaps, which causes release...
Based on phase-field theory, we develop a lattice Boltzmann (LB) model for liquid-gas-solid flow from multiphase and particle dynamics algorithms. A modified bounce-back method is developed the velocity-based LB approach. curved boundary treatment with second-order accuracy based velocity interpolation developed. We propose predictor-corrector scheme algorithm specifying three-phase contact angle boundaries within framework of structured Cartesian grids. In order to make more stable, combine...
Plasma protein adsorption on blood-contacting surfaces is the initiating significant event and modulates subsequent coagulation response. Despite decades of research in this area, Vroman's questions 1986 "Who gets there first?" "When does next arrive?" remain unanswered due to lack detection techniques with sufficient temporal resolution. In work, we develop a droplet microfluidic technology detect sequences six typical milliseconds. Apolipoproteins (Apo) are found be first proteins adsorb...
Microthrombus is one of the major causes sequelae Corona Virus Disease 2019 (COVID-19 and leads to subsequent embolism necrosis. Due their small size irregular movements, early detection efficient removal microthrombi in vivo remain a great challenge. In this work, an interventional method developed identify remove traveling using targeted-magnetic-microbubbles (TMMBs) magnetic catheter. The thrombus-targeted drugs are coated on TMMBs nanoparticles shelled inside, which allow not only...
Cavitation occurs widely in hydraulic machines, water and underwater vehicles, lots of other equipments operating with liquids. Much research has been carried out to find the factors affecting degree cavitation for better control this phenomenon. In study, effects grooves distributed around body revolution on are investigated using experimental numerical methods. The results show that position shape cavity clouds affected by dimensions grooves. A simulation finite volume method indicates...
Abstract Thrombosis is a major cause of morbidity and mortality sonothrombolysis promising method for its treatment. However, the slow diffusion thrombolytic agents into thrombus results in recanalization. Here, nanodroplet‐coated microbubbles (NCMBs) are designed fabricated two‐step cavitation strategy used to accelerate thrombolysis. The first NCMBs, collapse induced by low frequency ultrasound, drives nanodroplets on shell thrombus, while second cavitation, phase‐change volume expansion...
Abstract Margination of stiffened red blood cells has been implicated in many vascular diseases. Here, we report the margination RBCs vivo , and reveal crucial role vessel geometry by calculations when is seen as viscoelastic fluid. The vessel-geometry-regulated then confirmed vitro experiments microfluidic devices, it establishes new insights to cell sorting technology artificial fabrication.
Compared with monolithic materials, topologically interlocked materials (TIMs) exhibit higher toughness based on their enhanced crack deflection and deformation tolerance. Importantly, by reducing the block size of TIMs, structural strength can also be improved due to reduced flexural span. However, assembly microscale blocks remains a huge challenge inadequacy nanoscale self-assembly or macroscale pick-and-place operations. In this work, octahedral microblocks are fabricated constructed...
Abstract The left ventricular assist device (LVAD) is often used in the treatment of heart failure. However, 4% to 9% implanted LVAD will have thrombosis problem one year, which fatal patient's life. In this work, an interventional sonothrombolysis (IST) method developed realize thrombolysis on LVAD. A pair ultrasound transducer rings installed shell LVAD, and drug‐loaded microbubbles are injected into through method. adhere thrombus with coated thrombus‐targeted drugs, thrombolytic drugs...
Brush seals can improve engine performance by reducing leakage. Wear models of brush provide methods to predict wear and However, rotor eccentricity, radial deformation, hysteresis effect bristles are not considered systematically in the existing models, which may lead large errors some cases. To investigate influence rotor-stator eccentricity deformation on process leakage seal, a seal test was planned executed, air rates were measured at different testing times operating conditions, using...
Noncontacting finger seals are new compliant seal in gas turbine engine sealing technology. Their potential hydrodynamic and hydrostatic lifting capabilities make them preferable to brush contacting seals. The work concerns the mechanism of dynamic leakage noncontacting seal, a novel analysis model is proposed. combines together estimate performance through leakage. nature affected by change seal–rotor clearance revealed. Dynamic increasing mainly ratio friction force stiffness, mass natural...