A5043043463- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Mathematical Biology Tumor Growth
- Photoreceptor and optogenetics research
- Spine and Intervertebral Disc Pathology
- Tuberculosis Research and Epidemiology
- Anesthesia and Pain Management
- Biomedical and Chemical Research
- Cancer-related Molecular Pathways
- Medical History and Innovations
- Cholesterol and Lipid Metabolism
- Neural dynamics and brain function
- Nerve Injury and Rehabilitation
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Immune cells in cancer
- Photoacoustic and Ultrasonic Imaging
- Cancer, Lipids, and Metabolism
- Prostate Cancer Treatment and Research
University of Würzburg
2021-2024
Universitätsklinikum Würzburg
2020-2021
Comprehensive Cancer Center Mainfranken
2020
University of Lübeck
2003
Abstract Prostate cancer (PCa) shows strong dependence on the androgen receptor (AR) pathway. Here, we show that squalene epoxidase (SQLE), an enzyme of cholesterol biosynthesis pathway, is overexpressed in advanced PCa and its expression correlates with poor survival. SQLE controlled by micro-RNA 205 (miR-205), which significantly downregulated PCa. Restoration miR-205 or competitive inhibition led to de novo biosynthesis. Furthermore, was essential for proliferation AR-positive cell lines,...
Abstract Background: One third of patients with clear cell renal carcinoma (CCRCC) eventually develop metastasis. The introduction anti-angiogenic therapy and immunotherapy in metastatic CCRCC (mCCRCC) has significantly improved outcomes for many patients. Among vascular endothelial growth factor tyrosine kinase inhibitors (TKIs), sunitinib is the most commonly used first-line drug. However, treatment administered without specific patient selection criteria relapse occurs approximately 40%...
Immune checkpoint blockade (IO) has revolutionised the treatment of metastatic renal cell carcinoma (mRCC). Early C-reactive protein (CRP) kinetics, especially recently introduced CRP flare-response phenomenon, shown promising results to predict IO efficacy in mRCC, but only been studied second line or later. Here, we aimed validate predictive value early kinetics for 1st-line mRCC with αPD-1 plus either αCTLA-4 (IO+IO) tyrosine kinase inhibitor (IO+TKI).In this multicentre retrospective...
Although biomarkers predicting therapy response in first-line metastatic renal carcinoma (mRCC) remain to be defined, C-reactive protein (CRP) kinetics have recently been associated with immunotherapy (IO) response. Here, we aimed assess the predictive and prognostic power of two contemporary CRP definitions a large, real-world mRCC cohort.Metastatic patients treated IO-based within 5 years were retrospectively included this multicentre study. According Fukuda et al., defined as 'CRP...
Head and neck squamous cell carcinoma (HNSCC) is a widespread disease with low survival rate high risk of recurrence. Nowadays, immune checkpoint inhibitor (ICI) treatment approved for HNSCC as first-line in recurrent metastatic disease. ICI yields clear benefit, but overall response rates are still unsatisfactory. As shown different cancer models, hepatocyte growth factor/mesenchymal–epithelial transition (HGF/Met) signaling contributes to an immunosuppressive microenvironment. Therefore,...
The aim of this study was to test for differences in overall (OS) and progression-free survival (PFS) rates toxicity first-line immune checkpoint inhibition (IO) combination therapy metastatic renal-cell carcinoma (mRCC) patients.Between November 2017 April 2021, 104 patients with histologically confirmed mRCC from 6 tertiary referral centers either IO + (nivolumab ipilimumab, n = 68) or tyrosine kinase inhibitor (TKI) (pembrolizumab axitinib, 36) were included. Kaplan-Meier Cox regression...
405 Background: Although biomarkers predicting therapy response in 1 st line metastatic renal carcinoma (mRCC) remain to be defined, C-reactive protein (CRP) kinetics have recently been associated with immunotherapy (IO) response. To assess the predictive and prognostic power of two contemporary CRP definitions a large, real-world mRCC cohort. Methods: patients treated IO-based within 5 years were retrospectively included this multi-center study. According Fukuda et al., defined as ‘CRP...
Introduction: Adjuvant pembrolizumab versus placebo significantly improved disease-free survival (DFS) in renal cell carcinoma (RCC) patients at high risk of recurrence following nephrectomy KEYNOTE-564 trial (NCT03142334). The objective this study was to evaluate efficacy and safety adjuvant a real-world setting. Methods: In multicenter retrospective study, RCC receiving between 01/22 10/23 seven tertiary referral centers were included. DFS treatment assessed. Results: 52 with 24 (46%), 5...
Die vorliegende Arbeit stellt den zweiten Teil einer Untersuchung über die historische Entwicklung der inhalativen Sauerstofftherapie sowie ihre Beeinflussung durch Geschichte Anästhesiologie dar. Besonderes Augenmerk gilt dabei Entwicklungen im Bereich Druckgas- und Medizintechnologie, mit denen vor allem heutigen Drägerwerke wesentliche Beiträge zur technischen Ermöglichung rationalen leisteten. Daher illustrieren wir zunächst, dass es Drägerwerken insbesondere ihren Druckreduzierventilen,...