A5039482910- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Extracellular vesicles in disease
- Tissue Engineering and Regenerative Medicine
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Cancer, Lipids, and Metabolism
- Nanoplatforms for cancer theranostics
- Urologic and reproductive health conditions
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Renal and related cancers
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Microtubule and mitosis dynamics
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Ureteral procedures and complications
- Cholesterol and Lipid Metabolism
- MRI in cancer diagnosis
Saarland University
2015-2024
Universitätsklinikum des Saarlandes
2016-2022
University Medical Center
2016
University Hospital and Clinics
2016
Preliminary data from retrospective analyses and recent large randomized controlled trials suggest safety efficacy of radioligand therapy (RLT) targeting prostate-specific membrane antigen (PSMA) in men with metastatic castration-resistant prostate cancer (mCRPC). Limited on this modality have been published regarding samples treated everyday practice.We analyzed prospectively collected registry lutetium-177 (177Lu)-PSMA-617 RLT 254 consecutive mCRPC seen academic practice. Since...
Rationale: Despite the promising results of prostate-specific membrane antigen (PSMA)-targeted 177 Lu radioligand therapy in metastatic castration-resistant prostate carcinoma (mCRPC), some patients do not respond and other with initially good response develop resistance to this treatment.In study, we investigated molecular imaging biochemical responses after a single cycle [ 225 Ac]Ac-PSMA-617/[ Lu]Lu-PSMA-617 tandem who had progressed on monotherapy.Methods: Seventeen mCRPC were included...
Abstract Prostate cancer (PCa) shows strong dependence on the androgen receptor (AR) pathway. Here, we show that squalene epoxidase (SQLE), an enzyme of cholesterol biosynthesis pathway, is overexpressed in advanced PCa and its expression correlates with poor survival. SQLE controlled by micro-RNA 205 (miR-205), which significantly downregulated PCa. Restoration miR-205 or competitive inhibition led to de novo biosynthesis. Furthermore, was essential for proliferation AR-positive cell lines,...
Abstract Background Tumor cells benefit from their ability to avoid apoptosis and invade other tissues. The endoplasmic reticulum (ER) membrane protein Sec62 is a key player in these processes. essential for cell migration protects tumor against thapsigargin-induced ER stress, which are both linked cytosolic Ca 2+ . SEC62 silencing leads elevated increased leakage after thapsigargin treatment. levels significantly different tumors, including prostate, lung thyroid cancer. Methods In cancer,...
The use of 225Ac in prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT), either as monotherapy or combination with 177Lu, is a promising approach patients metastatic castration-resistant prostate carcinoma (mCRPC). In this study, we report the efficacy and safety [225Ac]Ac-PSMA-617 augmented [177Lu]Lu-PSMA-617 RLT 177Lu-naive mCRPC (n = 15) poor prognosis (presence visceral metastases, high total tumor burden diffuse bone metastases short PSA doubling time <2...
The molecular carcinogenesis of lung cancer has yet to be clearly elucidated. We investigated the possible oncogenic function SEC62 in cancer, which was predicted based on our previous findings that and thyroid tissue samples exhibited increased Sec62 protein levels. gene locus is at 3q26.2, 3q amplification reportedly most common genomic alteration non-small cell cancer. analyzed mRNA levels from patients by real-time quantitative PCR, Western blot, IHC found significantly tumors compared...
Background Does the dogma of nephron sparing surgery (NSS) still stand for large renal masses? Available studies dealing with that issue are considerably biased often mixing imperative elective indications NSS and also including less malignant variants or even benign tumors. Here, we analyzed oncological long-term outcomes patients undergoing radical tumor nephrectomy (RN) non-endophytic, (≥7cm) clear cell carcinoma (ccRCC). Methods Prospectively acquired, clinical databases from two...
Background: Radioligand therapy (RLT) targeting prostate-specific membrane antigen (PSMA) is an effective antitumor-treatment in metastatic castration-resistant prostate carcinoma (mCRPC). Concerns of potential nephrotoxicity are based on renal tubular PSMA expression and the resulting radiopharmaceutical retention during RLT, but data confirming clinically significant toxicity still lacking. In this study, patients with significantly impaired baseline kidney function before initiation were...
Abstract The unique microenvironment of the prostate plays a crucial role in development and progression cancer (PCa). We examined effects cancer-associated fibroblasts (CAFs) on PCa using patient-derived fibroblast primary cultures representative orthotopic xenograft model. Primary CAFs, non-cancer-associated (NCAFs) benign hyperplasia-associated (BPHFs) were generated from tissue specimens. These coinjected together with cells (LuCaP136 spheroids or LNCaP cells) xenografts to investigate...
Introduction: Metastasis-directed therapy (MDT) is a promising approach for recurrent or de novo oligo-metastatic castration-sensitive prostate cancer (omCSPC). The aim of this study was to evaluate the treatment approaches in omCSPC among German physicians. Methods: An anonymous online questionnaire sent via survio.com members Societies Urology and Radiooncology. Results: Participants (n=166; 33% urologists, 66% radiooncologists) define as ≤ 3 (31%) 4 (58%) metastases. Multimodal consisting...
Head and neck squamous cell carcinoma (HNSCC) is a malignancy with an increasing incidence. To aid the selection of most appropriate therapy, biomarkers have become specific research focus. Sec62 involved in endoplasmic reticulum stress tolerance migration, has been identified as novel prognostic marker for non-small lung cancer. In addition, may be promising candidate HNSCC. Pretreatment biopsies 35 patients locally advanced HNSCC, who were treated definitive chemoradiation therapy without...
Abstract Background Most comparisons between robot‐assisted partial nephrectomy (RAPN) and open (OPN) indicate the superiority of RAPN, but learning curve is often not considered. Methods All consecutive nephrectomies from very first RAPN at a single tertiary referral centre ( n = 818, 500 vs. 313 OPN) were retrospectively analyzed. Complications, success rates surgical outcomes compared. Inequalities cohorts inherent controlled by subgroup comparisons, regression analyses, propensity score...
At present, little is known about the molecular imaging-based response assessment of prostate-specific membrane antigen (PSMA)-targeted radioligand therapy with 177Lutetium (177Lu-PSMA-617 RLT) in metastatic castration-resistant prostate cancer (mCRPC). Our study evaluated to RLT using both imaging and biochemical assessments, their potential prediction progression-free survival (PFS). Fifty-one consecutive patients given two cycles at 6-week intervals were analyzed retrospectively....
Despite the promising results of prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) in metastatic castration-resistant prostate cancer (mCRPC), some patients show worsening disease during PSMA-RLT. We investigated value combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging this setting. In n = 29 mCRPC with after a median four cycles [177Lu]Lu-PSMA-617 RLT, was performed to detect [18F]FDG-avid lesions low or no PSMA expression (mismatch lesions). To evaluate...
Radical prostatectomy in oligometastatic prostate cancer is a matter of intense debate. Besides avoiding local complications, it hypothesized that primary tumor resection may result better oncological outcomes. The aim our study was to analyze the effect on disease progression an orthotopic mouse model. First, optimal time point for resection, when metastases have already occurred, but still resectable, determined as 8 weeks after inoculation 5 × 105 LuCaP136 cells. In second vivo...
In this study, we investigated upregulation of prostate-specific membrane antigen (PSMA) by enzalutamide in a cohort (n = 30) patients with advanced metastatic castration-resistant prostate cancer (mCRPC). Patients were examined [68Ga]Ga-PSMA-11 PET/CT pre- and post-enzalutamide medication (mean 13 ± 7 days). Imaging results compared based on quantification whole-body PSMA tumor burden: total lesion (TLP) normalized TLP values to liver (TLP-LR) parotid gland (TLP-PR). addition, lesion-based...
“Tumor sink effects”, decreased physiological uptake of radiopharmaceuticals due to sequestration by a tumor, may impact radioligand therapy (RLT) toxicity and dosing. We investigated these effects with prostate-specific membrane antigen (PSMA)-targeted in the healthy organs-at-risk (the parotid glands, kidneys, liver, spleen) 33 patients metastatic castration-resistant prostate cancer (mCRPC). retrospectively performed three intra-individual comparisons. First, we correlated changes from...
Abstract The prognostication of individual disease trajectory and selection optimal therapy in patients with localized, low-grade prostate cancer often presents significant difficulty. phosphatase tensin homolog on chromosome 10 (PTEN) has emerged as a potential novel biomarker this clinical context, based its demonstrated prognostic significance multiple retrospective studies. Incorporation into standard practice necessitates exceptional diagnostic accuracy, PTEN’s binary readout—retention...
Background In this study, we aimed to establish a versatile in vivo model of prostate cancer, which adequately mimics intraprostatic tumor growth, and the natural routes metastatic spread. addition, analyzed capability high‐resolution ultrasonography (hrUS), micro‐CT (μCT), 9.4T MRI monitor growth development lymph node metastases. Methods A total 5 × 10 VCaP cells or LuCaP136‐ LuCaP147 spheroids were injected into male CB17‐SCID mice ( n = 8 for each cell type). During 12 weeks follow‐up,...