A5061791226- Parkinson's Disease Mechanisms and Treatments
- Psychosomatic Disorders and Their Treatments
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurological disorders and treatments
- Neurological diseases and metabolism
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Mental Health and Psychiatry
- Action Observation and Synchronization
- Neurological and metabolic disorders
- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Dementia and Cognitive Impairment Research
- Neurobiology of Language and Bilingualism
- Paranormal Experiences and Beliefs
- Nuclear Receptors and Signaling
- Multiple Sclerosis Research Studies
- Mindfulness and Compassion Interventions
- Cerebrovascular and genetic disorders
- Attention Deficit Hyperactivity Disorder
- Cognitive Functions and Memory
- Face Recognition and Perception
- Pharmacological Effects and Toxicity Studies
Instituto de Neurología Cognitiva
2012-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2013-2025
Favaloro Foundation
2025
Foundation University
2025
Toronto Western Hospital
2020-2024
Favaloro University
2012-2024
Parkinson's Clinic of Eastern Toronto & Movement Disorders Centre
2023-2024
University Health Network
2024
University of Toronto
2024
Ontario Brain Institute
2023
Social cognition impairments are pervasive in the frontotemporal dementias (FTD). These deficits would be triggered by (a) basic emotion and face recognition processes as well (b) higher level social (e.g., theory of mind, ToM). Both emotional processing have been previously reported behavioral variant FTD (bvFTD) also other versions FTDs, including primary progressive aphasia. However, no neuroanatomic comparison between different variants has performed. We report selective recognition, ToM...
Interoception, the perception of our body internal signals, plays a key role in maintaining homeostasis and guiding behavior. Sometimes, we become aware signals use them planning strategic thinking. Here, show behavioral neural dissociations between learning to follow one's own heartbeat metacognitive awareness performance, heartbeat-tapping task performed before after auditory feedback. The electroencephalography amplitude heartbeat-evoked potential interoceptive learners, that is,...
Depersonalization-Derealization Disorder (DD) typically manifests as a disruption of body self-awareness. Interoception −defined the cognitive processing signals− has been extensively considered key for In consequence, purpose this study was to investigate whether there are systematic differences in interoception between patient with DD and controls that might explain disembodiment symptoms suffered disease. To assess interoception, we utilized heartbeat detection task measures functional...
Abstract Background Interoception refers to the conscious perception of body signals. Mindfulness is a meditation practice that encourages individuals focus on their internal experiences such as bodily sensations, thoughts, and emotions. In this study, we selected behavioral measure interoceptive sensitivity (heartbeat detection task, HBD) compare effect among long term practitioners (LTP), short meditators (STM, subjects completed Mindfulness-Based Stress Reduction (MBSR) program) controls...
Recent advances in neuroscience have provided new insights into the understanding of heart–brain interaction and communication. Cardiac information to brain relies on two pathways, terminating insular cortex (IC) anterior cingulate (ACC), along with somatosensory (S1-S2). Interoception relying these neuroanatomical pathways has been shown modulate social cognition. We report case study C.S., a patient an 'external heart' (an extracorporeal left-univentricular cardiac assist device, LVAD)....
Several clinical reports have stated that patients with prefrontal lesions or the behavioral variant of frontotemporal dementia share social cognition impairments. Moral reasoning is impaired in both conditions but there been few investigations directly compare this domain 2 groups.This work compared moral judgments these patient groups using a task designed to disentangle contributions intentions and outcomes judgment. For disorders, judged scenarios where protagonists believed they would...
Interoception refers to the ability sense body signals. Two interoceptive dimensions have been recently proposed: (a) sensitivity (IS) –objective accuracy in detecting internal bodily sensations (e.g., heartbeat, breathing)–; and (b) metacognitive interoception (MI) –explicit beliefs worries about one's own sensations. Current models of panic assume a possible influence on development attacks. Hypervigilance symptoms is one most characteristic manifestations disorders. Some explanations...
Abstract Objectives: Behavioral variant frontotemporal dementia (bvFTD) is characterized by early atrophy in the frontotemporoinsular regions. These regions overlap with networks that are engaged social cognition-executive functions, two hallmarks deficits of bvFTD. We examine (i) whether Network Centrality (a graph theory metric measures how important a node brain network) network disrupted bvFTD, and (ii) level involvement this social-executive performance. Methods: Patients probable...
Abstract Multiple sclerosis (MS) patients present several alterations related to sensing of bodily signals. However, no specific neurocognitive impairment has yet been proposed as a core deficit underlying such symptoms. We aimed determine whether MS changes in interoception—that is, the monitoring autonomic information—a process that might be various dysfunctions. performed two studies 34 relapsing–remitting, early‐stage and 46 controls matched for gender, age, education. In Study 1, we...
Objectives To evaluate the effect of Alzheimer's disease (AD) ‐related biomarker change on clinical features, brain atrophy and functional connectivity patients with corticobasal syndrome (CBS) progressive supranuclear palsy (PSP). Methods Data from a diagnosis CBS, PSP, AD healthy controls were obtained 4‐R‐Tauopathy Neuroimaging Initiative 1 2, Disease Initiative, local cohort Toronto Western Hospital. Patients CBS PSP divided into AD‐positive (CBS/PSP‐AD) AD‐negative (CBS/PSP‐noAD) groups...
There is no disease-modifying treatment of corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP), 2 disorders characterized by their striking phenotypic, and, in CBS, pathologic heterogeneity. Seed amplification assays (SAAs) could enable the detection neuropathologic processes, such as α-synuclein (αSyn) copathology, that affect success future strategies. The primary objective was to assess possible αSyn copathology CBS PSP, detected CSF using an SAA (αSyn-SAA). Secondary...
The ability to reappraise the emotional impact of events is related long-term mental health. Self-focused reappraisal (REAPPself), i.e., reducing personal relevance negative events, has been previously associated with neural activity in regions near right medial prefrontal cortex, but rarely investigated among brain-damaged individuals. Thus, we aimed examine REAPPself patients and healthy controls considering structural atrophies gray matter intensities, respectively. Twenty well-defined...
Background Liver transplantation (LT) is a life-saving intervention for end-stage liver disease; however, postoperative complications, particularly neurological issues such as seizures, pose significant challenges. This study aims to identify perioperative factors associated with seizures following LT and develop predictive risk model. By recognizing these in-hospital factors, clinicians may tailor management mitigate seizure improve outcomes. Methodology We conducted retrospective...
Abstract Background Chronic ataxias, a complex group of over 300 diseases, pose significant diagnostic challenges because their clinical and genetic heterogeneity. Here, we propose that artificial intelligence (AI) can aid in the identification understanding these disorders through utilization smart virtual assistant. Objectives The aim is to develop validate an AI‐powered assistant for diagnosing chronic ataxias. Methods A non‐commercial was developed using advanced algorithms, decision...
Interoception is the moment-to-moment sensing of physiological condition body. The multimodal sources interoception can be classified into two different streams afferents: an internal pathway signals arising from core structures (i.e., heart, blood vessels, and bronchi) external body-mapped sensations chemosensation pain) peripersonal space. This study examines differential processing along these within insular cortex (IC) their subcortical tracts connecting frontotemporal networks. Two rare...
In this study, we report an unusual case of mutidimensional sensorimotor, cognitive, and socio-affective preservation in adult with extensive, acquired bilateral brain damage. At age 43, patient CG sustained a cerebral hemorrhage and, few months later, she suffered second (ischemic) stroke. As result, exhibited extensive damage the right hemisphere (including frontal, temporal, parietal, occipital regions), left Sylvian striatal areas, portions insula amygdala, splenium. However, against all...
Progressive supranuclear palsy (PSP) is a 4R-tauopathy showing heterogeneous tau cytopathology commencing in the globus pallidus (GP) and substantia nigra (SN), regions also associated with age-related iron accumulation. Abnormal levels have been extensively pathology neurodegenerative brains, however, its role PSP pathogenesis remains yet unknown. We perform first cell type-specific evaluation of homeostasis closely related oxygen homeostasis, relation to human postmortem brains.In brain...
Abstract Progressive Supranuclear palsy (PSP) is a 4-repeat (4-R) tauopathy. We hypothesized that the molecular diversity of tau could explain heterogeneity seen in PSP disease progression. To test this hypothesis, we performed an extensive biochemical characterisation high weight species (HMW-Tau) 20 different brain regions 25 patients. found correlation between HMW-Tau and seeding capacity primary motor cortex, where confirmed elevated 4R-Tau activity correlates with shorter duration....
Abstract The most frequent neurodegenerative proteinopathies include diseases with deposition of misfolded tau or α-synuclein in the brain. Pathological protein aggregates PNS are well-recognized α-synucleinopathies and have recently attracted attention as a diagnostic biomarker. However, there is paucity observations tauopathies. To characterize involvement tauopathies, we investigated pathology cranial spinal nerves (PNS-tau) 54 tauopathy cases [progressive supranuclear palsy (PSP), n =...
Cockayne syndrome (CS) is an autosomal recessive disease associated with premature aging, progressive multiorgan degeneration, and nervous system abnormalities including cerebral cerebellar atrophy, brain calcifications, white matter abnormalities. Although several clinical descriptions of CS patients have reported developmental delay cognitive impairment relative preservation social skills, no previous studies carried out a comprehensive neuropsychological cognition assessment. Furthermore,...