A5032282249- Reproductive System and Pregnancy
- Birth, Development, and Health
- Parkinson's Disease Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Alzheimer's disease research and treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Animal testing and alternatives
- Genetic Neurodegenerative Diseases
- Cerebrovascular and Carotid Artery Diseases
- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Traumatic Brain Injury and Neurovascular Disturbances
- Regulation of Appetite and Obesity
- Cardiac Imaging and Diagnostics
- Neonatal Respiratory Health Research
- Acute Ischemic Stroke Management
- Functional Brain Connectivity Studies
- Meta-analysis and systematic reviews
- Trace Elements in Health
German Center for Neurodegenerative Diseases
2025
University of Toronto
2020-2024
Occupational Cancer Research Centre
2022-2024
University Health Network
2023-2024
Douglas Mental Health University Institute
2019-2023
McGill University
2019-2023
Toronto Western Hospital
2023
Douglas College
2023
There is no disease-modifying treatment of corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP), 2 disorders characterized by their striking phenotypic, and, in CBS, pathologic heterogeneity. Seed amplification assays (SAAs) could enable the detection neuropathologic processes, such as α-synuclein (αSyn) copathology, that affect success future strategies. The primary objective was to assess possible αSyn copathology CBS PSP, detected CSF using an SAA (αSyn-SAA). Secondary...
Objectives To evaluate the effect of Alzheimer's disease (AD) ‐related biomarker change on clinical features, brain atrophy and functional connectivity patients with corticobasal syndrome (CBS) progressive supranuclear palsy (PSP). Methods Data from a diagnosis CBS, PSP, AD healthy controls were obtained 4‐R‐Tauopathy Neuroimaging Initiative 1 2, Disease Initiative, local cohort Toronto Western Hospital. Patients CBS PSP divided into AD‐positive (CBS/PSP‐AD) AD‐negative (CBS/PSP‐noAD) groups...
Our current understanding of litter variability in neurodevelopmental studies using mice may limit translation neuroscientific findings. Higher variance measures across litters than within, often termed intra-litter likeness, be attributable to both pre- and postnatal environment. This study aimed assess the litter-effect within behavioral assessments (2 timepoints) anatomy T1-weighted magnetic resonance images 72 brain region volumes (4 (36 C57bl/6J inbred mice; 7 litters: 19F/17M)....
Dementia, a global public health challenge, is significantly influenced by lifestyle factors such as obesity. This study examines the impact of obesity and intervention approaches -physical exercise, low-fat diet, or both- on brain structure in triple-transgenic mouse model Alzheimer's disease (3xTgAD) wild-type mice fed high-fat diet. Volumetric deformation-based morphometry analyses showed significant neuroanatomical differences related to genotype particularly affecting hippocampus...
Abstract Background Misfolded α‐synuclein in Parkinson's disease (PD) and dementia with Lewy bodies (DLB) can be detected using the real‐time quaking‐induced conversion (RT‐QuIC) technique cerebrospinal fluid (CSF). Objectives The objectives are (1) to examine misfolded CSF incidence, (2) compare clinical presentation, sports history, brain volumes, RT‐QuIC positivity former athletes. Methods Thirty athletes magnetic resonance imaging, neuropsychological testing, analyzed for phosphorylated...
The long-term consequences of concussions may include pathological neurodegeneration as seen in Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE). Tau-PET showed promise a method to detect tau pathology CTE, but more studies are needed OBJECTIVE: This study aimed (1) assess the association imaging evidence with brain volumes retired athletes (2) examine relationship between tau-PET neuropsychological functioning.
This study quantified the occurrence of an underlying synucleinopathy in 50 patients with idiopathic normal pressure hydrocephalus by means real-time quaking-induced conversion, a highly sensitive and specific technique capable detecting amplifying misfolded aggregated forms α-synuclein cerebrospinal fluid. Seven were positive they did not differ from negative cases, except for more frequent L-dopa responsiveness gait characterized wider base. The two groups terms response rate to tap test...
Abstract Prenatal maternal immune activation (MIA) is a risk factor for neurodevelopmental disorders. How gestational timing of MIA-exposure differentially impacts downstream development remains unclear. Here, we characterize trajectories mice exposed to MIA induced by poly I:C either early (gestational day [GD]9) or late (GD17) in gestation using longitudinal structural magnetic resonance imaging from weaning adulthood. Early associated with accelerated brain volume increases...
Excerpt This study presents a ten-year experience in the diagnosis and management of acute myocardial infarction 150-bed general hospital La Crosse, Wisconsin, city 45,000 inhabitants. The cases were seen Lutheran Hospital Gundersen Clinic, which are attached share common medical records staff. Because policy this closed staff is to treat all heart attacks hospital, no patients treated at home. It believed, therefore, that report approximates with smaller midwestern hospitals United States. MATERIALS
MRI-detected white matter hyperintensities (WMH) are often recognized as markers of cerebrovascular abnormalities and an index vascular brain injury. The literature establishes a strong link between WMH burden cognitive decline, suggests that the anatomical distribution mediates dysfunction. Pathological remodeling major cerebral arteries (anterior, ACA; middle, MCA; posterior, PCA) may increase in arterial territory (AT)-specific manner. However, this has not been systematically studied...
Abstract The hypothalamus and pituitary regulate, amongst other functions, third order endocrine systems, their volumes have been associated with normal pathological outcomes. Yet, there are very few studies that examine combined structural variations in vivo . This is due, part, to small size a lack of comprehensive image segmentation protocols. In the current project we acquired high-resolution T1- (1mm isotropic) T2-weighted (0.4mm plane resolution) 3T magnetic resonance images (MRI)...
Abstract Our current understanding of litter variability in neurodevelopmental studies using mouse may limit translation neuroscientific findings. Higher variance measures across litters than within, often termed intra-litter likeness, be attributable to pre- and postnatal environment. This study aimed assess the litter-effect within behavioral assessments (2 timepoints), anatomy T1-weighted magnetic resonance images (4 timepoints) 72 brain region volumes (36 C57bl/6J inbred mice; 7 litters:...
<h3>Objective:</h3> To compare Cerebrospinal fluid (CSF) Neurofilament-light chain (NfL) and NfL/amyloid beta<sub>42</sub> (Abeta42) ratio levels in normal pressure hydrocephalus (NPH) patients with healthy controls (HC), Alzheimer's disease (AD), Frontotemporal lobar degeneration (FTLD). <h3>Background:</h3> Levels of CSF NfL have been shown to be a marker neuro-axonal injury are elevated neurodegenerative disease. One putative etiology NPH involves axonal injury; however, low Abeta42 has...
Abstract Background MRI‐detected white matter hyperintensities (WMHs), a marker of cerebrovascular‐pathology, are common in Alzheimer’s disease (AD) and related dementias (ADRDs). In stroke, WMH‐volume was found to correlate most with stroke risk‐factors the anterior cerebral arterial‐territory. Since relationship between WMHs arterial‐territories remains unexplored ADRDs, we systematically investigated WMHs’ spatial distribution (1) 8 ADRDs relative cognitively unimpaired (CU), (2) across...
Abstract Background Corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP) display phenotypic heterogeneity. CBS pathology can include 4‐repeat (4‐R) tau Alzheimer’s disease (AD) pathology/co‐pathology; while PSP involves predominantly 4‐R with AD co‐pathology. We evaluated whether in vivo biomarkers of are associated specific brain atrophy default mode network (DMN) alterations relates to clinical manifestations. Method analyzed MRIs 110 patients a diagnosis from 4RTNI‐1,...
Abstract Background Neuroinflammation is an important pathophysiological process in neurodegenerative diseases, such as Alzheimer’s disease (AD) and Frontotemporal Lobar Degeneration (FTLD). Limited studies have revealed distinct inflammatory markers between proteinopathies. Whether AD FTLD neuroinflammatory profiles that relate to different clinical manifestations remains unclear. We assayed a large number of proteins delineate signatures across Method Using Olink Inflammation panels, we...