A5022935133- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Adolescent Sexual and Reproductive Health
- Toxin Mechanisms and Immunotoxins
- HIV/AIDS Research and Interventions
- Pneumonia and Respiratory Infections
- Animal Virus Infections Studies
- interferon and immune responses
- Toxoplasma gondii Research Studies
- Virus-based gene therapy research
- Viral-associated cancers and disorders
- HIV/AIDS Impact and Responses
- Food Security and Health in Diverse Populations
Centers for Disease Control and Prevention
2013-2019
World Health Organization Regional Office for Europe
2015
United States Naval Medical Research Unit SOUTH
2015
Epidemic Intelligence Service
2013
University of Chicago
2005-2008
Background. Variant influenza virus infections are rare but may have pandemic potential if person-to-person transmission is efficient. We describe the epidemiology of a multistate outbreak an A(H3N2) variant (H3N2v) first identified in 2011.
Persons who work in close contact with dairy cattle and poultry that are infected highly pathogenic avian influenza (HPAI) A(H5N1) virus at increased risk for infection. In July 2024, the Colorado Department of Public Health & Environment responded to two facilities HPAI detections poultry. Across facilities, 663 workers assisting depopulation (i.e., euthanasia) received screening illness; 109 (16.4%) reported symptoms consented testing. Among those testing, nine (8.3%) a positive A(H5) test...
Co-circulation of influenza A(H5N1) and seasonal viruses among humans animals could lead to co-infections, reassortment, emergence novel with pandemic potential. We assessed the timing subtype H5N1 outbreaks poultry, human cases, in 8 countries that reported 97% all cases 90% poultry outbreaks. In these countries, most (7,001/11,331, 62%) half (313/625, 50%) occurred during January-March. Human 167 (45%) 372 months which occurred, compared 59 (10%) 574 had no poultry. also (22%) 267 periods....
Background Influenza‐associated illness results in increased morbidity and mortality the Americas. These effects can be mitigated with an appropriately chosen timed influenza vaccination campaign. To provide guidance choosing most suitable vaccine formulation timing of administration, it is necessary to understand seasonal epidemics. Objectives Our main objective was determine whether occurs patterns American tropics when these occurred. Methods Publicly available, monthly data from Pan...
Highly pathogenic avian influenza (HPAI) A(H5N1) virus, clade 2.3.4.4b, genotype B3.13 infection has been documented in cats on U.S. dairy cattle farms. In May 2024, the detection of HPAI virus two that were reported to be exclusively indoor, and had respiratory neurologic illness different households, prompted an investigation by Michigan Department Health Human Services Mid-Michigan District (MDHHS/MMDHD). The cats' owners household members interviewed offered testing for A(H5) virus....
Although information about the incidence of viral respiratory illnesses and their associated cost can help health officials explore value interventions, data are limited from middle-income countries. During 2008–2010, we conducted a prospective cohort study followed ~1,800 Argentinian children aged ≤5 years to identify those who were hospitalized or sought care at an emergency room with any acute infection sign symptom (e.g., rhinorrhea, cough, wheezing, tachypnea, retractions, cyanosis)....
Many countries, including South Africa, have implemented population-based household surveys to estimate HIV prevalence and the burden of infection. Most are designed provide reliable estimates down only first subnational geopolitical level which, in is composed nine provinces. However needed at least second order better target delivery care, treatment prevention services. The Africa 52 districts. Achieving adequate precision therefore requires either a substantial increase survey sample size...
The infected-cell protein 22 (ICP22), a regulatory encoded by the alpha22 gene of herpes simplex virus 1, is required for optimal expression set late viral proteins that includes products U(S)11, U(L)38, and U(L)41 genes. ICP22 has two activities. Thus, U(L)13 kinase mediate activation cdc2 degradation its partners, cyclins A B. new partner, DNA polymerase accessory factor (U(L)42), bind topoisomerase IIalpha in an ICP22-dependent manner. In addition, intermediate phosphorylation carboxyl...
ABSTRACT ICP22 is a multifunctional herpes simplex virus 1 (HSV-1) regulatory protein that regulates the accumulation of subset late (γ 2 ) proteins exemplified by U L 38, 41, and S 11. binds cyclin-dependent kinase 9 (cdk9) but not cdk7, this complex in conjunction with viral kinases phosphorylates carboxyl terminus RNA polymerase II (Pol II) vitro. The primary function cdk9 its partners, cyclin T variants, elongation transcripts, although functions related to initiation processing...
In 2012, one third of cases in a multistate outbreak variant influenza A(H3N2) virus ([H3N2]v) infection occurred Ohio. We conducted an investigation (H3N2)v associated with agricultural Fair A Ohio.We surveyed swine exhibitors and their household members. Confirmed had influenza-like illness (ILI) positive laboratory test for (H3N2)v, probable ILI. calculated attack rates. determined risk factors infection, using multivariable log-binomial regression.We identified 20 confirmed 94 A. Among...
In herpes simplex virus 1-infected cells, a high level of alpha gene expression requires the transactivation genes by complex containing viral transinducing factor (alphaTIF) and two cellular proteins. The latter two, HCF-1 octamer binding protein Oct-1, are transcriptional factors regulated in cell cycle-dependent manner. alphaTIF is made late infection but packaged with virion to transactivate newly infected cells. light accumulation large amounts alphaTIF, absence suggested possibility...
Earlier studies have shown that in herpes simplex virus 1-infected cells, ICP22 upregulates the accumulation of a subset gamma(2) proteins exemplified by products U(L)38, U(L)41, and U(S)11 genes. The ICP22-dependent process involves degradation cyclins A B1, stabilization activation cdc2, physical interaction activated cdc2 with U(L)42 DNA synthesis processivity factor, recruitment phosphorylation topoisomerase IIalpha cdc2/U(L)42 complex. Activation first step process, is key function...