A5027133082- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Infection Control in Healthcare
- Medical Device Sterilization and Disinfection
- Liver Disease Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Nosocomial Infections in ICU
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Healthcare cost, quality, practices
- Bacterial biofilms and quorum sensing
- Hepatitis C virus research
- Alcohol Consumption and Health Effects
- Antimicrobial Resistance in Staphylococcus
- Clostridium difficile and Clostridium perfringens research
- Liver physiology and pathology
- Child and Adolescent Health
- Urinary Tract Infections Management
- Infection Control and Ventilation
- COVID-19 Clinical Research Studies
- Pregnancy and preeclampsia studies
- Vibrio bacteria research studies
- Antibiotics Pharmacokinetics and Efficacy
- Dental Research and COVID-19
- SARS-CoV-2 and COVID-19 Research
Erasmus MC
2016-2025
Southern California Coastal Water Research Project
2022-2024
Massachusetts General Hospital
2024
Erasmus University Rotterdam
2011-2024
Queen Elizabeth Hospital Birmingham
2005-2023
University Hospitals Birmingham NHS Foundation Trust
2017-2019
Birmingham Children's Hospital
2017
Lee Memorial Health System
2017
Queen Elizabeth Hospital
2017
NIHR Surgical Reconstruction and Microbiology Research Centre
2012
<b>Background and study aims:</b> Infections are a recognized risk of endoscopic retrograde cholangiopancreatography (ERCP). This paper reports on large outbreak VIM-2-producing <i>Pseudomonas aeruginosa</i> that was linked to the use recently introduced duodenoscope with specific modified design (Olympus TJF-Q180V). <b>Methods:</b> Epidemiological investigations molecular typing were executed in order identify source outbreak. Audits implementation infection control measures performed....
BackgroundThe burden of liver disease in the UK has risen dramatically and there is a need for improved diagnostics.AimsTo determine which breath volatiles are associated with cirrhotic hence diagnostically useful.MethodsA two-stage biomarker discovery procedure was used. Alveolar samples 31 patients cirrhosis 30 healthy controls were mass spectrometrically analysed compared (stage 1). 12 these had their after transplant 2). Five followed longitudinally as in-patients post-transplant...
Increasing numbers of outbreaks caused by contaminated duodenoscopes used for Endoscopic Retrograde Cholangiopancreatography (ERCP) procedures have been reported, some with fatal outcomes. We conducted a nationwide cross-sectional study to determine the prevalence bacterial contamination reprocessed in The Netherlands.All 73 Dutch ERCP centres were invited sample ≥2 using centrally distributed kits according uniform sampling methods, explained video instructions. Depending on duodenoscope...
Donation after cardiac death (DCD) liver transplantation is associated with an increased frequency of hepato-biliary complications. The implications for renal function have not been explored previously. aims this single-center study 88 consecutive DCD transplant recipients were (1) to compare outcomes propensity-risk-matched donation brain (DBD) patients and (2) in the specifically examine risk factors acute kidney injury (AKI; peak creatinine ≥2 times baseline) chronic disease (CKD; eGFR...
Hand hygiene is recognized as an important measure to prevent healthcare-associated infections. adherence among healthcare workers associated with their knowledge and perception. This study aimed evaluate the effect of three different educational programs on improving hand compliance, knowledge, perception in a tertiary care hospital Indonesia. The was performed from May October 2014 divided into pre-intervention, intervention, post-intervention phase. cluster randomized controlled trial...
Breath samples were taken from 31 patients with liver disease and 30 controls in a clinical setting proton transfer reaction quadrupole mass spectrometry (PTR-Quad-MS) used to measure the concentration of volatile organic compounds (VOCs). All had cirrhosis various etiologies, some also suffering hepatocellular cancer (HCC) and/or hepatic encephalopathy (HE). limonene was higher No-HCC than HCC, median (lower/upper quartile) 14.2 (7.2/60.1) versus 3.6 (2.0/13.7) 1.5 (1.1/2.3) nmol mol−1...
Inanimate surfaces within hospitals can be a source of transmission for highly resistant microorganisms (HRMO). While many are transitioning to single-occupancy rooms, the effect rooms on environmental contamination is still unknown. We aimed determine differences in with HRMO between an old hospital building mainly multiple-occupancy and new 100% during three years after relocating. Environmental samples were taken twice hospital, fifteen times over three-year period hospital. Replicate...
Background/Objectives: The global spread of carbapenem-resistant Pseudomonas aeruginosa (CRPA) warrants collaborative action. Guidance should come from integrated One Health surveillance; however, a surveillance strategy is currently unavailable due to insufficient knowledge on the sources and transmission routes CRPA. aim SAMPAN study (“A Smart Surveillance Strategy for Carbapenem-resistant aeruginosa”) develop globally applicable strategy. Methods: First, an international cross-sectional...
<h2>Abstract</h2><h3>Background</h3> Alcohol and obesity synergise to increase the risk of liver-related mortality. We examined influence adiposity on clinical outcomes in alcoholic hepatitis (AH) underlying inflammatory crosstalk between adipose tissue (AT) liver. <h3>Methods</h3> A cohort 233 patients with AH from UK USA provided data analyse effects AH. Body mass index was corrected for severity ascites, termed cBMI. Inflammatory metabolic profiling undertaken by proteome analysis human...
SARS-CoV-2 Omicron variants BA.1 and BA.2 seem to show reduced clinical severity compared with earlier variants. Therefore, we aimed assess classify the cause of hospitalization for patients COVID-19 identified these in our hospital.A retrospective analysis was performed on all variant between December 23, 2021, February 27, 2022. Patients a positive polymerase chain reaction (PCR) upon admission or during were classified into four categories: (1) primary COVID-19, (2) admission-contributing...
Abstract Background Infection prevention and control (IPC) in hospitals is key to safe patient care. There currently no data regarding the implementation of IPC Indonesia. The aim this study was assess existing level a nationwide survey, using World Health Organization (WHO) assessment framework tool (IPCAF), identify strengths, gaps, challenges. Methods A cross-sectional conducted from July November 2021. Of all general Indonesia, 20% (N = 475) were selected stratified random sampling based...
Background In healthcare environments, sinks are being increasingly recognized as reservoirs for multidrug-resistant Gram-negative bacteria. our hospital, carbapenemase-producing, Verona Integron-encoded Metallo-beta-lactamase (VIM)-positive Pseudomonas aeruginosa (VIM-PA) was detected at low endemicity in patients, and environmental culturing revealed that sink drains were primary reservoirs. Therefore, an intervention initiated several wards to install drain plugs physical barriers against...
Healthcare facilities have been challenged by the risk of SARS-CoV-2 transmission between healthcare workers (HCW) and patients. During first wave COVID-19 pandemic, infections among HCW were observed, questioning infection prevention control (IPC) measures implemented at that time.This study aimed to identify nosocomial routes patients in a tertiary care hospital.All PCR positive identified 1 March 19 May 2020, included analysis. Epidemiological data collected from patient files contact...
Objective To measure recruitment to, compliance with, and the acceptability of a trial designed to test whether reduced schedule antenatal visits combined with training in self‐measurement blood pressure at home may improve hypertension screening save money. specific hypothesis that even after taking into account extra unscheduled visits, ambulatory monitoring reduces total visits. Design A pilot randomised controlled trial. Setting Four urban four rural general practices Yorkshire...
Background With 249,007 new leprosy patients detected globally in 2008, it remains necessary to develop and effective interventions interrupt the transmission of M. leprae. We assessed economic benefits single dose rifampicin (SDR) for contacts as chemoprophylactic intervention control leprosy. Methods conducted a centre, double blind, cluster randomised, placebo controlled trial northwest Bangladesh between 2002 2007, including 21,711 close 1,037 with newly diagnosed gave or contacts,...
Abstract Background Hospital outbreaks of multidrug resistant Pseudomonas aeruginosa are often caused by clones which produce metallo-β-lactamases, such as Verona Integron-encoded Metallo-β-lactamase (VIM). Although different sources have been identified, the exact transmission routes remain unknown. However, quantifying role VIM-PA is important for tailoring infection prevention and control measures. The aim this study to quantify relative importance applying a mathematical model using...