A5019957852- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Dendrimers and Hyperbranched Polymers
- Supramolecular Self-Assembly in Materials
- Molecular Sensors and Ion Detection
- Mitochondrial Function and Pathology
- Luminescence and Fluorescent Materials
- Silicone and Siloxane Chemistry
- Supramolecular Chemistry and Complexes
- Chemical Synthesis and Characterization
- Organometallic Compounds Synthesis and Characterization
- Protein Structure and Dynamics
- Origins and Evolution of Life
- Genetics, Bioinformatics, and Biomedical Research
- DNA and Nucleic Acid Chemistry
- Click Chemistry and Applications
Universität Ulm
2022-2023
A growing number of out-of-equilibrium systems have been created and investigated in chemical laboratories over the past decade. One way to achieve this is create a reaction cycle, which forward driven by fuel backward follows different pathway. Such dissipative networks are still relatively rare, however, most non-enzymatic examples based on carbodiimide-driven generation carboxylic acid anhydrides. In work, we describe network that comprises chemically fueled formation phosphoramidates...
Abstract The aqueous self‐assembly of amphiphiles into aggregates such as micelles and vesicles has been widely investigated over the past decades with applications ranging from materials science to drug delivery. combination characteristic properties nucleic acids is substantial interest mimic biological self‐organization compartmentalization. Herein, we present ribose‐ ribonucleotide‐based investigate their well fundamental reactivity. We found that various types are formed, in size...
The increased importance of RNA-based therapeutics comes with a need to develop next-generation stimuli-responsive systems capable binding, transporting and releasing RNA oligomers. In this work, we describe triazolium-based amphiphiles siRNA binding enzyme-responsive release the nucleic acid payload. aqueous medium, amphiphile self-assembles into nanocarriers that can disintegrate upon addition esterase. Key molecular design is self-immolative linker anchored triazolium moiety acts as...
The supramolecular recognition of anions is increasingly harnessed to achieve the self-assembly architectures, ranging from cages and polymers (pseudo)rotaxanes. cyanostar (CS) macrocycle has previously been shown form 2 : 1 complexes with organophosphate that can be turned into [3]rotaxanes by stoppering. Here we achieved steric control over assembly pseudorotaxanes comprising a thread based, for first time, on organo-pyrophosphonates. Subtle differences in bulk threads allowed formation...